Browse our GAB2 Proteins (GAB2)

Human GRB2-Associated Binding Protein 2 (GAB2) interaction partners

1. a common locus (rs3740677) in 3' UTR of GAB2 sequence which is targeted by the miRNA-185 was explored the probable associations of rs3740677 with risk for late-onset AD (LOAD) in a large scale case-control study from Chinese Han populations.

2. we provided evidences to imply that miR (show MLXIP Proteins)-302c-3p downregulation in human RCC (show XRCC1 Proteins) cells causes Gab2 over-expression, Akt (show AKT1 Proteins) hyper-activation and cell proliferation.

3. study identified that GAB2 as an adaptor protein was preferentially induced in Th2 differentiation and regulated Th2 immune responses

4. The proto-oncogene (show RAB1A Proteins) GAB2 (11q14.1) was significantly amplified in non-smokers patients and GAB2 protein was relatively up-regulated in non-smoker than smoker tissues. GAB2 may represent a potential biomarker for lung SCC (show CYP11A1 Proteins) in non-smokers

5. There was no significant association between single nucleotide polymorphisms (SNPS) of GAB2 rs2373115 (G > T) and PICALM (show PICALM Proteins) rs541458 (C > T) and Alzheimer's disease (AD). The allele T of rs3851179 in PICALM (show PICALM Proteins) was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 (show SORL1 Proteins) were significantly associated with AD.

6. Results show that up-regulation of Gab2 expression was found to be positively correlated with VEGF (show VEGFA Proteins) in colorectal cancer (CRC (show CALR Proteins)) tissues, and suggest that Gab2 promotes intestinal tumor growth and angiogenesis through upregulation of VEGF (show VEGFA Proteins) expression mediated by the MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins)/c-Myc (show MYC Proteins) pathway.

7. The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 and their complexes with Shp2 (show PTPN11 Proteins). VEGFR2 (show KDR Proteins) recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 (show KDR Proteins) complexes more transiently than Gab1, VEGFR2 (show KDR Proteins) complexes can recycle and continue to participate in other signaling pathways.

8. The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.

9. Studied BAK1 (show BAK1 Proteins), SPRY4 (show SPRY4 Proteins) and GAB2 SNPs in pediatric germ cell tumors(GCT (show QPCT Proteins)); found a variant in SPRY4 (show SPRY4 Proteins) was associated with reduced risk of GCT (show QPCT Proteins); a variant in BAK1 (show BAK1 Proteins) was positively associated with GCT (show QPCT Proteins) with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT (show QPCT Proteins).

10. overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating expression of CXCL1 (show CXCL1 Proteins), CXCL2 (show CXCL2 Proteins) and CXCL8 (show IL8 Proteins) that is IKKbeta (show IKBKB Proteins)-dependent.

Mouse (Murine) GRB2-Associated Binding Protein 2 (GAB2) interaction partners

1. we demonstrated for the first time that Gab2 deficiency has a profound effect on the course of disease in an in vivo chronic myeloid leukemia (show BCL11A Proteins) model

2. High Gab2 expression is associated with myeloproliferative neoplasm.

3. Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.

4. Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r (show IL4R Proteins), synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r (show IL4R Proteins) = interleukin-4 receptor (show IL4R Proteins))

5. Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms

6. Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.

7. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development

8. These results define a novel role for Gab2 in mediating mucin (show SLC13A2 Proteins) gene expression and GCH (show GCH1 Proteins); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.

9. Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion

10. Data indicate that fetal liver cells isolated from homozygous STAT5 (show STAT5A Proteins) mutant mice lacking Gab2 showed significant reduction in HSC (show FUT1 Proteins) number and survival.