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Interactions between HPK1 and its adaptor proteins related to immunity has been discussed (Review).
HPK1 protein expression, which is expressed at significantly higher levels in NATs compared with paired IDC (show LMNA Proteins)-NOS (show NOS1 Proteins) tissues, is significantly negatively associated with ER positivity and is positively associated with OS duration, suggesting that HPK1 may exhibit anticancer activities.
CUL7/Fbxw8 (show FBXW8 Proteins) ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7/Fbxw8 (show FBXW8 Proteins) ubiquitin ligase in the MAPK (show MAPK1 Proteins) pathway, which plays a critical role in cell proliferation and differentiation.
HPK1 is critically involved in LFA-1 (show ITGAL Proteins)-mediated polymorphonuclear neutrophils trafficking during acute inflammation.
results indicate that uncleaved HPK1 is a positive regulator of vitamin D-induced differentiation in acute myeloid leukemia (show BCL11A Proteins) cells, but the cleaved HPK1 fragment inhibits differentiation
Pdcd4 (show PDCD4 Proteins) knockdown up-regulates MAP kinase (show MAPK1 Proteins) kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun (show JUN Proteins).
QVD and 1,25D-induced differentiation was accompanied by increased signaling by Hematopoietic Progenitor Kinase 1(HPK1), and the expression of transcription factors known to be involved in monocytic differentiation was increased.
HPK1 negatively regulates T cell activation by reducing the persistence of signaling microclusters.
The purpose of the study was to investigate the potential contribution of HPK1, MEKK1 (show MAP3K1 Proteins), TAK1 (show MAP3K7 Proteins), p-MKK4 (show MAP2K4 Proteins) to the development of extramammary Paget disease
The catalytic activity of a hematopoietic cell-restricted, Ste20-related S/TPK, HPK1, is positively regulated by exposure to physiological concentrations of PGE2. HPK1 is a negative regulator of PGE2-induced FOS gene transcription.
Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin (show CTTN Proteins) binding of HPK1 peptide.
a novel negative feedback regulation of BCR (show BCR Proteins) signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK (show BLNK Proteins)
HPK1 associates with SKAP1 (show SKAP1 Proteins) to negatively regulate Rap1 (show TERF2IP Proteins)-mediated B-lymphocyte (show AKAP17A Proteins) adhesion.
HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
Hpk1 supports apoptosis of T lymphocytes by inhibiting the antiapoptotic action of NF-kappaB (show NFKB1 Proteins) and inducing the proapoptotic activity of JNK (show MAPK8 Proteins).
Mona/Gads (show GRAP2 Proteins) SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
suppression or activation of NFkappaB by HPK1 determines sensitivity to activation-induced cell death
HPK1-C as a suppressor of antiapoptotic Bcl-2 (show BCL2 Proteins) proteins and provide a molecular basis for our understanding of CD95L (show FASL Proteins)-independent activation-induced cell death of lymphocytes.
Our data reveal a novel role for HPK1 as a negative regulator of dendritic cell functions
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.
mitogen-activated protein kinase kinase kinase kinase 1
, MAPK/ERK kinase kinase kinase 1
, MEK kinase kinase 1
, MEKKK 1
, hematopoietic progenitor kinase 1
, mitogen activated protein kinase kinase kinase kinase 1