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ATM-dependent monoubiquitylation of histone H2B is required for timely repair of DNA double-strand breaks
The present findings provide evidence indicating that the extrachromosomal histone H2B is engaged in the signaling pathway initiated by dsDNA to trigger antiviral innate immune responses.
Histone H2B represents a regulated plasminogen (show PLG Antibodies) receptor, which contributes significantly to the plasminogen (show PLG Antibodies) binding capacity of cells.
infertile men have a higher proportion of spermatozoa with diffuse histone H2B
USP7 (show USP7 Antibodies) can stimulate EBNA1 (show EBNA-1 Antibodies)-DNA interactions and EBNA1 (show EBNA-1 Antibodies) can alter histone modification at oriP through recruitment of USP7 (show USP7 Antibodies).
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.
H2B type 12
, histone 3, H2bb
, histone H2B type 3-B