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|Antigen||Toll-Like Receptor 6 (TLR6) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This TLR6 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-TLR6 AntibodyTarget Details TLR6 Application Details Handling Images
|Specificity||This antibody reacts to a peptide corresponding to 15 amino acids near the amino terminus of TLR6.|
Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
|Plasmids, Primers & others|
Target Details TLR6Product Details anti-TLR6 Antibody Application Details Handling Images back to top
|Alternative Name||CD286 / TLR6 (TLR6 Antibody Abstract)|
|Background||The Toll like receptor family in mammal comprises a family of transmembrane proteins characterised by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. These proteins recognize different microbial products during infection and serve as an important phylogenetically conserved mediator/link between the innate and adaptive immune responses. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLRs characterised so far activate the MyD88/interleukin 1 receptor associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1 10) have been described. TLR6 was first identified as a close homolog of TLR1, sharing 69 % sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates proinflammatory cascades, but also can lead to apoptotic responses.Synonyms: Toll-like receptor 6|
|Pathways||TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-TLR6 Antibody Target Details TLR6 Handling Images back to top
Western Blot: 1-2 μg/mL. Immunocytochemistry. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TLR6 Antibody Target Details TLR6 Application Details Images back to top
|Buffer||Phosphate buffered saline containing 0.02 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ImagesProduct Details anti-TLR6 Antibody Target Details TLR6 Application Details Handling back to top