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V-ATPase G1 (show ATP6V1G1 Proteins) and G2 isoforms are expressed in mouse embryo neurons and are involved in synaptic vesicle acidification
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene.
ATPase, H+ transporting, V1 subunit G
, V-ATPase subunit G 1
, V-type proton ATPase subunit G 1
, vacuolar proton pump subunit G 1
, V-type proton ATPase subunit G 2
, ATPase, H+ transporting, lysosomal (vacuolar proton pump)
, H(+)-transporting two-sector ATPase, subunit G2
, V-ATPase 13 kDa subunit 2
, vacuolar ATP synthase subunit G 2
, vacuolar proton pump G subunit 2
, ATPase, H+ transporting, lysosomal V1 subunit G2
, V-ATPase subunit G 2
, vacuolar proton pump subunit G 2
, Vacuolar proton pump subunit G 1
, Vacuolar proton pump subunit G 2
, ATPase, H+ transporting, lysosomal 13kD, V1 subunit G
, lysosomal 13kDa
, vacuolar ATPase NG38