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|Antigen||Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) Antibodies|
|Conjugate||This CAMK2A antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
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Product Details anti-CAMK2A AntibodyTarget Details CAMK2A Application Details Handling References for anti-CAMK2A antibody (ABIN359578) Images
|Specificity||This antibody reacts to CAMK2A.|
|Purification||Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CAMK2A.|
Target Details CAMK2AProduct Details anti-CAMK2A Antibody Application Details Handling References for anti-CAMK2A antibody (ABIN359578) Images back to top
|Alternative Name||CAMK2A (CAMK2A Antibody Abstract)|
|Background||CAMK2A belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by the gene for CAMK2A is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity.Synonyms: CAMKA, CaM kinase II subunit alpha, CaM-kinase II alpha chain, CaMK-II subunit alpha, Calcium/calmodulin-dependent protein kinase type II alpha chain, KIAA0968|
|Gene ID||815, 9606|
|Pathways||WNT Signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction|
Application DetailsProduct Details anti-CAMK2A Antibody Target Details CAMK2A Handling References for anti-CAMK2A antibody (ABIN359578) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CAMK2A Antibody Target Details CAMK2A Application Details References for anti-CAMK2A antibody (ABIN359578) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-CAMK2A antibody (ABIN359578)Product Details anti-CAMK2A Antibody Target Details CAMK2A Application Details Handling Images back to top
Lee, Lin, Luo, Lee, Lee, Aird, Hwang, Yang et al.: "Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and ..." in: Molecular pharmacology, Vol. 73, Issue 5, pp. 1454-64, 2008
Yuan, Chung, Siegal, Zayzafoon: "alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 87, Issue 9, pp. 938-50, 2007
ImagesProduct Details anti-CAMK2A Antibody Target Details CAMK2A Application Details Handling References for anti-CAMK2A antibody (ABIN359578) back to top