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anti-Human LRP6 Antibodies:
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Human Polyclonal LRP6 Primary Antibody for IHC (p), WB - ABIN390100
Brown, Twells, Hey, Cox, Levy, Soderman, Metzker, Caskey, Todd, Hess: Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. in Biochemical and biophysical research communications 1998
Show all 4 Pubmed References
Human Polyclonal LRP6 Primary Antibody for CyTOF, FACS - ABIN4899465
Gustafson, Smith: Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance. in The Journal of biological chemistry 2010
Show all 2 Pubmed References
Human Monoclonal LRP6 Primary Antibody for CyTOF, FACS - ABIN4899464
Madan, Walker, Young, Quick, Orgel, Ryan, Gupta, Henrich, Ferrer, Marine, Roberts, Arthur, Berndt, Oliveira, Moon, Virshup, Chou, Major: USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. in Proceedings of the National Academy of Sciences of the United States of America 2016
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Human Polyclonal LRP6 Primary Antibody for IHC (p), IHC - ABIN250317
Liu, Mani, Davis, Sarrafzadegan, Kavathas, Mani: Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance. in Circulation research 2008
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Human Polyclonal LRP6 Primary Antibody for IF (cc), IF (p) - ABIN743558
Chen, Xu, Ye, Li, Gong, Zhang, Wu, Jia, Liu, Chen, Yang, Tang, Zhu, Ge, Zou: Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling. in Journal of cellular and molecular medicine 2014
Show all 2 Pubmed References
Lrp6 asymmetry is controlled by Wnt (show WNT2 Antibodies)/PCP (show PRCP Antibodies) signaling, indicating that this pathway regulates not only planar- but also apicobasal cell polarity.
PTK7 (show PTK7 Antibodies) and LRP6 proteins physically interact, suggesting that PTK7 (show PTK7 Antibodies) stabilization of LRP6 protein reciprocally regulates both canonical and noncanonical Wnt (show WNT2 Antibodies) activities in the embryo.
Results suggest that Rap2 (show RAP2A Antibodies) acts via TNIK (show TNIK Antibodies) to regulate the stability of LRP6 receptor for Wnt (show WNT2 Antibodies) signaling.
The extracellular domains of Lrp5 (show LRP5 Antibodies)/6 behave as physiologically relevant inhibitors of noncanonical Wnt (show WNT2 Antibodies) signaling during Xenopus and mouse development in vivo.
Lrp6 plays a critical role in the switch from Wnt (show WNT2 Antibodies)/PCP (show PRCP Antibodies) to Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
Kremen2 (show KREMEN2 Antibodies) knockdown specifically reduces LRP6 protein levels in neural crest explants.
Waif1a binds to the Wnt (show WNT2 Antibodies) coreceptor LRP6 (show LRP5 Antibodies) and inhibits Wnt (show WNT2 Antibodies)-induced LRP6 (show LRP5 Antibodies) internalization into endocytic vesicles, a process that is required for pathway activation.
Results identify GRK5 (show GRK5 Antibodies)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP5 Antibodies) during Wnt (show WNT2 Antibodies) signaling.
data suggest that LRP6 promotes negative breast cancer cell migration and invasion by regulating the expression and function of S100A4 (show S100A4 Antibodies) via the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway
sustained activation of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling due to abrogation of Merlin (show NF2 Antibodies)-mediated inhibition of LRP6 phosphorylation may be a cause of Neurofibromatosis type II disease.
LRP6 ectodomain becomes highly compact upon complexation with the Wnt (show WNT2 Antibodies) antagonist Dkk1 (show DKK1 Antibodies), suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling.
identify ANGPTL4 (show ANGPTL4 Antibodies) as a Wnt (show WNT2 Antibodies) signaling antagonist that binds to syndecans and forms a ternary complex with the Wnt (show WNT2 Antibodies) co-receptor Lipoprotein receptor-related protein 6
The authors show that folding of the Wnt (show WNT2 Antibodies) signaling coreceptor LRP6 is promoted by ubiquitination of a specific lysine, retaining it in the ER while avoiding degradation.
Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta (show GSK3b Antibodies)/E2F1 (show E2F1 Antibodies) axis-upregulated LSH (show HELLS Antibodies) promoted gliomas.
Structure of the dual-mode Wnt (show WNT2 Antibodies) regulator Kremen1 (show KREMEN1 Antibodies) and insight into ternary complex formation with LRP6 and DKK1 (show DKK1 Antibodies) have been presented.
VAP1 (show AOC3 Antibodies) cleaved the extracellular region of LRP6 at Glu1196-Leu1197, the C-terminus of the 4th propeller domain. This cleavage removes four inhibito (show AOC3 Antibodies)ry beta-propeller st (show CDH5 Antibodies)ructures, resulting in activation of LRP5/6.
We identified a frameshift (c.4594delG, p.Cys1532fs) and a canonical splice-site mutation (c.3398-2A>C, p.?) in LRP6, respectively, in the patient with tooth agenesis (TA) and orofacial clefting (OFC) and in the patient with severe TA only. Mutations in LRP6 cause TA in humans
findings revealed an unrecognized role of Caprin-2 (show CAPRIN2 Antibodies) in facilitating LRP5 (show LRP5 Antibodies)/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (show CDK14 Antibodies), Cyclin Y (show CCNY Antibodies), and LRP5 (show LRP5 Antibodies)/6.
GPR37 is required for Wnt/beta-catenin signaling and protects LRP6 from ER-associated degradation via CHIP (carboxyl terminus of Hsc70-interacting protein) and the ATPase VCP
Lrp6 is the key mediator of Wnt3a (show WNT3A Antibodies) signaling in osteoblasts and Lrp5 (show LRP5 Antibodies) played a less significant role in mediating Wnt3a (show WNT3A Antibodies) signaling.
VAP1 (show AOC3 Antibodies) cleaved recombinant mouse LRP6, producing a 140-kDa fragment. An antibody against a peptide including the LRP6-cleavage site inhibited VAP1 (show AOC3 Antibodies)-induced VE-cadherin (show CDH5 Antibodies) relocation and disruption of cell-cell adhesions and blocked haemorrhage in mice in vivo.
we identified Lrp6, the gene encoding the coreceptor to Frizzled in the Wnt (show WNT2 Antibodies) pathway, as a potential negative regulator of precursor proliferation. Overexpression and siRNA silencing confirmed the regulatory role of Lrp6
These results revealed a new role of the canonical Lrp5 (show LRP5 Antibodies)/6-beta-catenin (show CTNNB1 Antibodies) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
Data (including data from studies in knockout/transgenic mice) suggest Lrp6 is required for suppression of Sost (sclerostin (show SOST Antibodies)) expression by parathyroid hormone (show PTH Antibodies) (here, human PTH (show PTH Antibodies) peptide 1-34); LRP6 regulates osteocytes expression of histone deacetylases.
Lrp5 (show LRP5 Antibodies) binds to Frizzled, preventing Frz-regulated non-canonical Wnt (show WNT2 Antibodies) pathway activation and further non-canonical pathway-mediated tumour metastasis.
Wt1 (show WT1 Antibodies) expression levels in podocytes regulate Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling through modulating the endocytic fate of LRP6, and this indicates a potential target for the therapy of CKD.
N-cadherin (show CDH2 Antibodies) modulates Lrp6/PTHR1 (show PTH1R Antibodies) interaction, restraining the intensity of parathyroid hormone (show PTH Antibodies)-induced beta-catenin (show CTNNB1 Antibodies) signaling
LRP6 restrains vascular smooth muscle lineage noncanonical signals that promote osteochondrogenic differentiation, mediated in part via USF1 (show USF1 Antibodies)- and arginine methylation-dependent relays.
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
low density lipoprotein receptor-related protein 6
, lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6-like
, low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6
, low density lipoprotein-related protein 6