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anti-Human SFRP2 Antibodies:
anti-Mouse (Murine) SFRP2 Antibodies:
anti-Rat (Rattus) SFRP2 Antibodies:
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Human Polyclonal SFRP2 Primary Antibody for ELISA, WB - ABIN259122
Urakami, Shiina, Enokida, Kawakami, Kawamoto, Hirata, Tanaka, Kikuno, Nakagawa, Igawa, Dahiya: Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Human Polyclonal SFRP2 Primary Antibody for WB - ABIN4890986
Sari, Rufaut, Jones, Sinclair: Characterization of Ovine Dermal Papilla Cell Aggregation. in International journal of trichology 2016
cysteine-rich domain of sFRP2 is sufficient for Ror2 (show ROR2 Antibodies) activation, and related sFRPs can substitute for this function. Notably, direct interaction of the two receptors via their cysteine-rich domains also promotes Ror2 (show ROR2 Antibodies)-mediated papc (show PCDH8 Antibodies) expression but inhibits Fz7 (show FZD7 Antibodies) signaling.
augments Wnt3a (show WNT3A Antibodies)-mediated beta-catenin (show CTNNB1 Antibodies) signalling in dermal papilla cells, especially in beard dermal papilla cells
SFRP2 methylation is associated with colorectal cancer development.
TET1 (show TET1 Antibodies) potently inhibited canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 and DKK1 (show DKK1 Antibodies), which was associated with inhibition of EMT (show ITK Antibodies) and cancer cell metastasis.
SFRP2 could bind to locally present Wnt (show WNT2 Antibodies) ligands and alter the balance of intracellular Wnt (show WNT2 Antibodies) signaling to antagonize the canonical Wnt (show WNT2 Antibodies) pathway in stem cells from the apical papilla.
SFRP2 induction is remarkable in tumor stroma, with transcription mainly modulated by the nuclear factor-kappaB (NF-kappaB (show NFKB1 Antibodies)) complex, a property shared by several effectors of the DNA damage secretory program.
down-regulated in ICU-acquired weakness and mice with inflammation-induced muscle atrophy; possibly establishes a positive feedback loop enhancing TGF-beta1 (show TGFB1 Antibodies)-mediated atrophic effects in inflammation-induced atrophy
epigenetic silencing of Wnt (show WNT2 Antibodies) antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 (show DKK2 Antibodies) could be a potential marker for a prognosis of poor overall survival.
SFRP2 enhances the adipogenic and neurogenic differentiation (show NEUROD1 Antibodies) potentials of stem cells from apical papilla by up-regulating SOX2 (show SOX2 Antibodies) and OCT4 (show POU5F1 Antibodies).
SFRP2 is not only an agonist of Wnt (show WNT2 Antibodies) pathway, but also a cancer promoting protein for lung cancer.
DKK1 (dickkopf-1 (show DKK1 Antibodies)) and SFRP2 (secreted frizzled-related protein 2) were the targets of miR (show MLXIP Antibodies)-522 in hepatocellular carcinoma
Sfrp2 expression in the niche is required to maintain the hematopoietic stem cell pool.
these data reveal a novel mechanism that the Bmp4 (show BMP4 Antibodies)-Msx1 (show MSX1 Antibodies) pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt (show WNT2 Antibodies) antagonists.
The functional versatility and signaling complexity of sFRP2 in cardiac fibrosis may be better defined.
A novel role of Sfrp2 and Wnt6 in regulating the dynamic process of CPC proliferation and differentiation.
SREBP-1 (show SREBF1 Antibodies) acts as a positive regulator of Sfrp2 transcription in chondrogenic cells.
In cardiac fibroblasts, sFRP2 promotes cardiac fibrocalcification through activation of TNAP (show ALPL Antibodies).
SFRP2 is suggested to modulate the influx from extracellular calcium in the B cell receptor signaling pathway.
sFRP2 controls apoptosis, cell fate and the Wnt (show WNT2 Antibodies) pathway in intestinal epithelium.
Bone morphogenetic protein 2 (BMP2 (show BMP2 Antibodies)), BMP4 (show BMP4 Antibodies), and secreted frizzled related protein 2 are principal effectors of quiescence of adult mammalian retinal stem cells.
Sfrp1 (show SFRP1 Antibodies) and Sfrp2 appear to have a positive regulatory function because Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in lens epithelial cells was reduced in Sfrp1 (show SFRP1 Antibodies) and Sfrp2 DKO mice
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.
secreted frizzled-related protein 2
, secreted frizzled-related sequence protein 2
, secreted frizzled-related protein
, secreted apoptosis related protein 1
, secreted apoptosis-related protein 1
, secreted frizzled related protein 2
, secreted frizzled-related sequence protein 5
, stromal cell derived factor 5
, secreted frizzled-related protein-2