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anti-Human TLE4 Antibodies:
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the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt (show WNT2 Antibodies) signaling activity
the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer.
PPM1B (show PPM1B Antibodies) interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing.
Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 (show ID1 Antibodies) gene induced by BMP7 (show BMP7 Antibodies).
Displacing coactivators CREB-binding protein (show CREBBP Antibodies)/p300 (show EP300 Antibodies) while promoting the recruitment of a corepressor, Grg4.
Grg4 recruits the arginine methyltransferase PRMT5 (show PRMT5 Antibodies) to chromatin resulting in symmetric H4R3 dimethylation.
germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein.
Gbx2 (show GBX2 Antibodies) and Otx2 (show OTX2 Antibodies) interact with the WD40 domain (show DCAF12L2 Antibodies) of Groucho/Tle corepressors
Knockdown of TLE1 (show TLE1 Antibodies) or TLE4 levels increased the rate of cell division of the AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies)-expressing Kasumi-1 cell line, whereas forced expression of either TLE1 (show TLE1 Antibodies) or TLE4 caused apoptosis and cell death.
Grg4 blocks Nodal-induced mesodermal gene expression and Nodal autoregulation. Grg4 occupancy of the Xnr1 (show NODAL Antibodies) enhancer is dependent on the FoxH1 (show FOXH1 Antibodies) EH1 (show EPHX1 Antibodies) motif. Grg4 occupancy at this enhancer significantly decreases with Nodal activation or Smad2 (show SMAD2 Antibodies) overexpression. Nodal-activated Smad2 (show SMAD2 Antibodies) physically displaces Grg4 from FoxH1 (show FOXH1 Antibodies). When FoxH1 (show FOXH1 Antibodies) is unable to bind Smad2 (show SMAD2 Antibodies), Grg4 occupancy is maintained at the Xnr1 (show NODAL Antibodies) enhancer.
Results identify the transcriptional co-repressor xTLE1/Groucho as an EphrinB1 (show EFNB1 Antibodies) interacting protein.
The localized activation of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling, which converts Tcf (show HNF4A Antibodies) from a repressor to an activator, is required for the establishment of dorsal-ventral patterning in the prospective diencephalon.
Bowline is a novel protein interacting with Groucho/TLE and may play a role in somitogenesis
These results demonstrated that TLE4 might play important regulatory roles in cellular proliferation and EMT (show ITK Antibodies) process in HCC (show FAM126A Antibodies).
Tle4 KO mice are runted, have defects in bone development, bone marrow aplasia. Have leukocytopenia, b-cell lymphoma and reductions in stem cells by 2 weeks. Die by 4 weeks.
TLE3 (show TLE3 Antibodies)/4 activity is essential for early differentiation where it acts to suppress the pluripotency network, allowing for the initiation of lineage specific gene expression programs
Blimp1 (show PRDM1 Antibodies)-dependent recruitment of Tle4 to the Ifng (show IFNG Antibodies) locus causes epigenetic silencing of the expression of the Ifng (show IFNG Antibodies) gene in anergic TH1 (show HAND1 Antibodies) cells.
Grg4 is an interacting partner for Cux1 (show CUX1 Antibodies) and suggest a mechanism of p27(kip1 (show CDKN1B Antibodies)) repression by Cux1 (show CUX1 Antibodies) during kidney development.
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
, transducin-like enhancer protein 4
, transducin-like enhancer protein 4-like
, B lymphocyte gene 1
, Protein BCE-1
, enhancer of split groucho 4
, transducin-like enhancer of split 4, homolog of Drosophila E(sp1)
, transducin-like enhancer of split 4, E(spl) homolog
, transducin-like enhancer of split 4, homolog of Drosophila E(spl)
, Groucho-related gene 4
, groucho protein
, groucho-related gene 4
, transducin-like enhancer of split 4
, groucho-related protein 4