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Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phosp.
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The direct reinforcing effects of a 5-HT(2C)R-selective antagonist in any species.
5HT1A (show HTR1A Antibodies) receptor may lose sensitivity to the suppressive effect of estradiol after 5 months, whereas the 5HT2C receptor increases, however, addition of progesterone in the EP5 regimen maintains the regulatory effects
results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.
Social Behavioral Deficits Coincide with the Onset of Seizure Susceptibility in Mice Lacking Serotonin Receptor 2c.
This study showed that reduced expression of the 5ht1c which modulate antidepressant action in hippocampus.
Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor (show ESR1 Antibodies) activation in aged male mice.
Results show that mice solely expressing the unedited INI (show PHF5A Antibodies) form of 5-HT2C receptors exhibit a hyperactive HPA (show HPSE Antibodies) axis driven by increased CRH (show CRH Antibodies), a normal response to chronic stress and decreased depressive-like behaviors and fear-associated memory
Chronic intermittent ethanol upregulates 5HT2C receptor signaling in the bed nucleus of the stria terminalis.
findings show that enhanced alcohol drinking behaviour in mice is associated with the degree of 5-HT(2C)R mRNA editing in the nucleus accumbens and dorsal raphe nuceus
Precise temporal control of Gq signals in 5-HT2c-R domains in GABAergic neurons upstream of 5-HT (show DDC Antibodies) neurons provides negative feedback regulation of serotonergic firing to modulate anxiety-like behavior in mice.
Results of the current study suggest aggression displayed by TLX (show NR2E1 Antibodies) null and heterozygous mice involves 5-HT(2A (show HTR2A Antibodies)/C) receptors.
Mice lacking Htr2c specifically in POMC (show POMC Antibodies) neurons had normal weight but developed glucoregulatory defects: hyperinsulinemia, hyperglucagonemia, hyperglycemia, & insulin (show INS Antibodies) resistance. These neurons are needed to control energy & glucose homeostasis.
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations.
5-hydroxytryptamine (serotonin) receptor 2C
, 5-hydroxytryptamine receptor 2c
, 5HT2C serotonin receptor
, 5-hydroxytryptamine receptor 2C
, 5-HT2C receptor
, 5-hydroxytryptamine receptor 1C
, serotonin receptor 2C
, serotonin 1c receptor