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anti-Amyloid P Component, serum (APCS) Antibodies

The protein encoded by APCS is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. Additionally we are shipping Amyloid P Component, serum Kits (46) and Amyloid P Component, serum Proteins (32) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APCS 325 P02743
APCS 29339 P23680
APCS 20219 P12246
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Top anti-Amyloid P Component, serum Antibodies at antibodies-online.com

Showing 10 out of 114 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB APCS Antibody (C-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the APCS antibody detected the APCS protein (arrow). APCS antibody (C-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the APCS antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB APCS antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the APCS antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. APCS Antibody (C-term) western blot analysis in K562 cell line lysates (35µg/lane).This demonstrates the APCS antibody detected the APCS protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-APCS Antibody Titration: 1.25ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated EIA, IHC (p), IP, WB 50 μL Log in to see 6 to 8 Days
$500.50
Details
Mouse Rabbit Un-conjugated ELISA, WB Western blot analysis of human and mouse serum using 1 µg/mL Rabbit Anti-Serum Amyloid P Polyclonal Antibody (ABIN398517) Secondary antibody: Goat Anti-Rabbit IgG (H&L) [HRP] Polyclonal Antibody (ABIN398323, 1: 20,000) The signal was developed with LumiSensorTM HRP Substrate Kit (ABIN769939) 40 μg Log in to see 3 to 4 Days
$147.40
Details
Human Mouse Un-conjugated WB APCS antibody  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the APCS antibody detected the APCS protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated IHC (p), ELISA, WB Anti-Serum Amyloid P Picoband antibody,  IHC(P): Mouse Kidney Tissue Anti-Serum Amyloid P Picoband antibody,  All lanes: Anti-Serum Amyloid P at 0.5ug/ml WB: Recombinant Mouse Serum Amyloid P Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Rat Rabbit Un-conjugated IHC (p), WB Anti-Serum Amyloid P Picoband antibody,  All lanes: Anti- Serum Amyloid P at 0.5ug/ml WB: Recombinant Rat Serum Amyloid P Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD Anti-Serum Amyloid P Picoband antibody,  IHC(P): Rat Liver Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated EIA, RIA   0.2 mg Log in to see 6 to 8 Days
$709.50
Details

APCS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Amyloid P Component, serum Antibodies

  1. Human Polyclonal APCS Primary Antibody for EIA, IHC (p) - ABIN954752 : Song, Cai, Guo, Tsukamoto, Yutani, Li: Accumulation and expression of serum amyloid P component in human atherosclerotic lesions. in Atherosclerosis 2010 (PubMed)
    Show all 5 references for ABIN954752

  2. Mouse (Murine) Polyclonal APCS Primary Antibody for ELISA, WB - ABIN1573937 : Maher, Dargusch, Ehren, Okada, Sharma, Schubert: Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. in PLoS ONE 2011 (PubMed)
    Show all 3 references for ABIN1573937

  3. Human Polyclonal APCS Primary Antibody for IHC, WB - ABIN2777091 : Veerhuis, Boshuizen, Morbin, Mazzoleni, Hoozemans, Langedijk, Tagliavini, Langeveld, Eikelenboom: Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q. in Neurobiology of disease 2005 (PubMed)
    Show all 2 references for ABIN2777091

  4. Human Polyclonal APCS Primary Antibody for IHC (p), WB - ABIN654634 : Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: New genetic associations detected in a host response study to hepatitis B vaccine. in Genes and immunity 2010 (PubMed)

More Antibodies against Amyloid P Component, serum Interaction Partners

Human Amyloid P Component, serum (APCS) interaction partners

  1. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN (show CD209 Antibodies) to regulate the innate immune system differently from C-reactive protein (CRP (show CRP Antibodies)), and that DC-SIGN (show CD209 Antibodies) is a target for antifibrotics.

  2. Here, it is reported that X-ray analysis of the SAP complex with CPHPC and cadmium ions provides higher resolution detail of the interaction than is observed with calcium ions.

  3. Compared to wildtype C57BL/6 mice, we find that in Apcs-/- "SAP knock-out" mice, bleomycin induces a more persistent inflammatory response and increased fibrosis.

  4. The effects of SAP and Xiapex (Collagenase Clostridium histolyticum) on fibrocytes derived from Dupuytren's disease, was evaluated.

  5. plasma protein serum amyloid P binds to FcgammaRI (show FCGR1A Antibodies) on monocytes to inhibit fibrocyte differentiation, and binds to FcgammaRIIa on neutrophils to reduce neutrophil adhesion.

  6. In the late phase post-myocardial infarct there is a coordinated decrease in immune response-inflammation proteins, except for SAP which showed an increase related to the specific activation of the classical complement pathway.

  7. 9 different proteins (haptoglobin (show HP Antibodies), transthyretin (show TTR Antibodies), apolipoprotein A-1 (show APOA1 Antibodies), serum amyloid P component, apolipoprotein E (show APOE Antibodies), complement factor H (show CFH Antibodies), fibrinogen gamma, thrombin (show F2 Antibodies), complement C3 (show C3 Antibodies)) were identified as a potential diagnostic pattern of Parkinson's disease.

  8. Human SAP binds phosphoethanolamine, while rabbits seem to have low levels of SAP that bind to a lesser extent.

  9. These results indicate that SAP functions as a host defense factor, similar to other peptidoglycan recognition proteins and nucleotide-binding oligomerization domain-like receptors.

  10. SAP may act as an effective receptor mimic to limit influenza A virus infection of airway epithelial cells.

Mouse (Murine) Amyloid P Component, serum (APCS) interaction partners

  1. SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE (show APOE Antibodies)(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines

  2. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN (show CD209 Antibodies) to regulate the innate immune system differently from C-reactive protein (CRP (show CRP Antibodies)), and that DC-SIGN (show CD209 Antibodies) is a target for antifibrotics.

  3. observations suggest that serum amyloid P, at least in part, uses FcgammaRI (show FCGR1A Antibodies) and FcRgamma (show FCER1G Antibodies) to inhibit fibrocyte differentiation

  4. Bglu3 is confirmed to be a locus affecting diabetes susceptibility, and Apcs is a probable candidate gene.

  5. binding of SAP to ALD (show ABCD1 Antibodies)-DNA could switch macrophage phenotypic polarization from proinflammatory M2b to anti-inflammatory M2a via PI3K/Akt (show AKT1 Antibodies)-ERK (show EPHB2 Antibodies) signaling activation, thus exerting protective and therapeutic interventions on murine lupus nephritis

  6. SAP has an effect on macrophages in fibrotic lung disease

  7. sFRP4 (show SFRP4 Antibodies) negatively regulates bone formation without disrupting phosphorus homeostasis.

  8. Binding of mouse and human SAP to immobilized influenza virus was compared. Mouse SAP bound much less avidly than human SAP.mouse SAP apparently plays no significant role during infection of mice with influenza virus.

  9. Targeted pharmacological depletion of serum amyloid P component for treatment of amyloidosis

  10. during murine tuberculosis (TB) SAP levels were increased; purified mouse SAP inhibited the intra-alveolar macrophage M. tuberculosis growth, in vitro; SAP may thus contribute both to the pathogenesis and pulmonary innate immunity in TB

Amyloid P Component, serum (APCS) Antigen Profile

Protein Summary

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

Gene names and symbols associated with APCS

  • amyloid P component, serum (APCS) antibody
  • amyloid P component, serum (Apcs) antibody
  • C-reactive protein, pentraxin-related (CRP) antibody
  • serum amyloid P-component (Apcs) antibody
  • serum amyloid P-component-like (LOC100352593) antibody
  • APCS antibody
  • PTX2 antibody
  • Sap antibody

Protein level used designations for APCS

amyloid P component, serum , pentraxin , C-reactive protein , amyloid P component serum , 9.5S alpha-1-glycoprotein , pentaxin-related , serum amyloid P-component , serum amyloid P component , Serum amyloid P-component , SAP , APCS amyloid P-component serum protein

GENE ID SPECIES
457427 Pan troglodytes
100126558 Meleagris gallopavo
325 Homo sapiens
396921 Sus scrofa
29339 Rattus norvegicus
100726823 Cavia porcellus
514488 Bos taurus
776376 Gallus gallus
20219 Mus musculus
100352593 Oryctolagus cuniculus
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