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anti-Berardinelli-Seip Congenital Lipodystrophy 2 (Seipin) (BSCL2) Antibodies

BSCL2 encodes the multi-pass transmembrane protein protein seipin. Additionally we are shipping BSCL2 Proteins (9) and BSCL2 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BSCL2 26580 Q96G97
Anti-Rat BSCL2 BSCL2 361722 Q5FVJ6
Anti-Mouse BSCL2 BSCL2 14705 Q9Z2E9
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Top anti-BSCL2 Antibodies at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB BSCL2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BSCL2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. BSCL2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35µg/lane).This demonstrates the BSCL2 antibody detected the BSCL2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-BSCL2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: U937 cell lysate WB Suggested Anti-BSCL2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: U937 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB BSCL2 Antibody (N-term) (ABIN654071) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of BSCL2 expression in transfected 293T cell line by BSCL2 polyclonal antibody (A02).Lane1:BSCL2 transfected lysate (Predicted MW: 44.5 KDa).Lane2:Non-transfected lysate. BSCL2 polyclonal antibody (A02). Western Blot analysis of BSCL2 expression in Jurkat. 50 μL Log in to see 9 Days
$298.57
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged BSCL2 is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB Western Blot analysis of BSCL2 expression in transfected 293T cell line by BSCL2 MaxPab polyclonal antibody.Lane 1: BSCL2 transfected lysate(44.50 KDa).Lane 2: Non-transfected lysate. BSCL2 MaxPab rabbit polyclonal antibody. Western Blot analysis of BSCL2 expression in human colon. 100 μg Log in to see 9 Days
$418.57
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit PE IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged BSCL2 is approximately 0.1ng/ml as a capture antibody. Western Blot detection against Immunogen (36.63 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37 KDa) . 50 μL Log in to see 9 Days
$298.57
Details

BSCL2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-BSCL2 Antibodies

  1. Human Polyclonal BSCL2 Primary Antibody for EIA, IHC (p) - ABIN954710 : Luigetti, Fabrizi, Madia, Ferrarini, Conte, Delgrande, Tonali, Sabatelli: Seipin S90L mutation in an Italian family with CMT2/dHMN and pyramidal signs. in Muscle & nerve 2010 (PubMed)
    Show all 3 references for ABIN954710

  2. Human Polyclonal BSCL2 Primary Antibody for ELISA, WB - ABIN1327730 : Cui, Wang, Meng, Fei, Deng, Xu, Peng, Ju, Zhang, Liu, Zhao, Yang: Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy. in American journal of physiology. Endocrinology and metabolism 2012 (PubMed)
    Show all 2 references for ABIN1327730

  3. Human Polyclonal BSCL2 Primary Antibody for WB - ABIN525761 : Hölttä-Vuori, Salo, Ohsaki, Suster, Ikonen: Alleviation of seipinopathy-related ER stress by triglyceride storage. in Human molecular genetics 2013 (PubMed)

More Antibodies against BSCL2 Interaction Partners

Human Berardinelli-Seip Congenital Lipodystrophy 2 (Seipin) (BSCL2) interaction partners

  1. Increased aggregation and subsequent impaired oligomerization of Celia seipin leads to cell death. In heterozygous carriers, wildtype seipin might prevent the damage caused by mutant seipin through its sequestration into harmless mixed oligomers.

  2. BSCL2 defines the localization of adipose differentiation-related protein (show PLIN2 Antibodies), which has a role in lipid accumulation and adipogenic differentiation

  3. BSCL2 mutations account for a small number of patients with inherited neuropathies in Taiwan. The p.R96H mutation is associated with distal hereditary motor neuropathy.

  4. We confirmed reduction of brain volume and number of sperm in human patients with BSCL2 mutation. This is the first report demonstrating that seipin is necessary for normal brain development and spermatogenesis

  5. The S90L mutationof BSCL2 is predominantly associated with Silver syndrome

  6. The mutation of seipin at glycosylation sites disrupt its function in regulating lipid droplet metabolism, and the autophagy acts as an adaptive response to break down abnormal lipid droplets.

  7. a brief overview of the genetic association of the CGLs, and focus on the current understanding of differential contributions of distinct seipin domains to lipid storage and adipogenesis.

  8. A missense mutation was found in BSCL2 N88S, in a patient with Silver syndrome.

  9. A homozygous and truncating mutation was identified in the BSCL2 gene suggesting congenital generalized lipodystrophy.

  10. Here, we report teratozoospermia syndrome in a lipodystrophic patient with compound BSCL2 mutations, with sperm defects resembling the defects of infertile seipin null mutant mice.

Mouse (Murine) Berardinelli-Seip Congenital Lipodystrophy 2 (Seipin) (BSCL2) interaction partners

  1. The results indicate that, by reducing PPARgamma (show PPARG Antibodies), seipin deficiency impairs proliferation and differentiation of neural stem and progenitor cells.

  2. Authors generated adipose tissue (mature) Bscl2 knockout (Ad-mKO) mice to investigate the impact of acquired Bscl2 deletion on adipose tissue function and energy balance.

  3. The present study provides in vivo evidence that neuronal seipin deficiency leads to spatial cognitive deficits thtat can be rescued by the activation of PPARgamma (show PPARG Antibodies).

  4. spermatid apoptosis, increased chromocenter fragmentation, abnormal acrosome formation, and defective mitochondrial activity contributed to decreased sperm production and defective sperm that resulted in Bscl2-/- male infertility.

  5. Bscl2(-/-) females have accelerated postnatal mammary ductal development but delayed vaginal opening; they display segregated responses in mammary gland development and vaginal opening to prepubertal genistein treatment.

  6. Using the lipodystrophic Seipin-deficient mouse (Seipin(-/-)) model, the study found Seipin(-/-) mice were unable to respond appropriately to a long time fasting and developed postprandial hypertriglyceridemia.

  7. a brief overview of the genetic association of the CGLs, and focus on the current understanding of differential contributions of distinct seipin domains to lipid storage and adipogenesis.

  8. Neuronal seipin deficiency causing reduced PPARgamma (show PPARG Antibodies) levels leads to affective disorders in male mice that are rescued by estradiol-increased PPARgamma (show PPARG Antibodies) expression.

  9. New insights into the metabolic adaptations of liver in response to fasting and uncovered a novel fasting-dependent regulation of hepatic insulin (show INS Antibodies) signaling in a mouse model of human Berardinelli-Seip congenital lipodystrophy type 2.

  10. other than being essential for adipocyte differentiation, Bscl2 is also important in fatty acid remodeling and energy homeostasis.

BSCL2 Antigen Profile

Protein Summary

This gene encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2).

Gene names and symbols associated with BSCL2

  • Berardinelli-Seip congenital lipodystrophy 2 (seipin) (BSCL2) antibody
  • Berardinelli-Seip congenital lipodystrophy 2 (seipin) (Bscl2) antibody
  • Bernardinelli-Seip congenital lipodystrophy 2 homolog (human) (Bscl2) antibody
  • 2900097C17Rik antibody
  • AI046355 antibody
  • Gng3lg antibody
  • HMN5 antibody
  • SPG17 antibody

Protein level used designations for BSCL2

Bernardinelli-Seip congenital lipodystrophy type 2 protein , seipin , Bernardinelli-Seip congenital lipodystrophy 2 (seipin) , bernardinelli-Seip congenital lipodystrophy type 2 protein homolog , G protein gamma 3 linked

GENE ID SPECIES
26580 Homo sapiens
476054 Canis lupus familiaris
513558 Bos taurus
361722 Rattus norvegicus
14705 Mus musculus
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