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CD47 encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Additionally we are shipping CD47 Antibodies (319) and CD47 Kits (12) and many more products for this protein.
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TSP1 (show GZMA Proteins) significantly accelerates replicative senescence and associated cell cycle arrest in a CD47-dependent manner.
CD47, TSP1 (show GZMA Proteins), and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.
In pulmonary hypertension TSP1 (show GZMA Proteins)-CD47 is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
thrombospondin-1 (show THBS1 Proteins) via CD47 inhibits renal tubular epithelial cell recovery after ischemia reperfusion injury through inhibition of proliferation/self-renewal.
these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity
this study shows that CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (show GZMA Proteins)/CD47 axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
These results identify CD47 as an important regulator of LFA-1 (show ITGAL Proteins) and VLA-4 integrin-adhesive functions in T cell proliferation.
Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47-SIRPA (show SIRPA Proteins) interaction and Rac1/Akt (show AKT1 Proteins) activation.
CD47 deficient mice with vaccination showed greater protective efficacy against lethal challenge.
In pulmonary hypertension TSP1 (show THBS1 Proteins)-CD47 is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
Engineering macrophages to eat cancer: from "marker of self" CD47 and phagocytosis to differentiation
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (show THBS1 Proteins)/CD47 axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
Results indicated that surgical resection combined with anti-CD47 blocking immunotherapy promoted an inflammatory response and prolonged survival in xenograft animal model, and is therefore an attractive strategy for clinical translation.
Results show that the stronger expression of CD47 by cancer cells and larger number of total macrophages/M2 were independently related to shorter survivals.
Prolongation of transient porcine chimerism via transgenic expression of human CD47 in a primate model is associated with an immune modulating effect, leading to markedly prolonged survival of donor swine skin xenografts.
CD47 is a promising cancer biomarker, and targeting CD47 presents an effective and potential therapeutic strategy through synthesized mechanisms
CD47 seems to mediate fusion mostly through broad contact surfaces between the partners' cell membrane while syncytin-1 (show ERVW-1 Proteins) mediate fusion through phagocytic-cup like structure.
The results suggested a critical role of CD47 in laryngeal squamous cell carcinoma development.
Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Proteins)- and CD47-dependent manner
Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.
, integrin-associated protein
, leukocyte surface antigen CD47
, CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
, CD47 glycoprotein
, antigen identified by monoclonal antibody 1D8
, antigenic surface determinant protein OA3
, integrin associated protein
, integrin-associated signal transducer
, CD47 antigen