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CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Additionally we are shipping Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein) Proteins (32) and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein) Kits (27) and many more products for this protein.
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Human Monoclonal CEACAM1 Primary Antibody for EIA, FACS - ABIN114594
Hammarström: The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. in Seminars in cancer biology 1999
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Human Monoclonal CEACAM1 Primary Antibody for FACS - ABIN2689373
Kuroki, Arakawa, Matsuo, Oikawa, Misumi, Nakazato, Matsuoka: Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. in The Journal of biological chemistry 1991
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Human Monoclonal CEACAM1 Primary Antibody for FACS - ABIN2689374
Siler, Eggensperger, Hand, Milenic, Miller, Houchens, Hinkle, Schlom: Therapeutic efficacy of a high-affinity anticarcinoembryonic antigen monoclonal antibody (COL-1). in Biotechnology therapeutics 1994
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Human Monoclonal CEACAM1 Primary Antibody for IHC (p), WB - ABIN3043635
Li, Chen, Zeng, Li, Zhang, Lin, Zhang, Xie, He, Shu, Yang, Tang, Fu: Matrigel basement membrane matrix induces eccrine sweat gland cells to reconstitute sweat gland-like structures in nude mice. in Experimental cell research 2015
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Human Monoclonal CEACAM1 Primary Antibody for CyTOF, FACS - ABIN4900284
Rahmoun, Molès, Pedretti, Mathieu, Fremaux, Raison-Peyron, Lecron, Yssel, Pène: Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. in The Journal of investigative dermatology 2009
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Human Monoclonal CEACAM1 Primary Antibody for FACS - ABIN4897487
Gebauer, Wicklein, Tachezy, Grob, Steinemann, Manukjan, Göhring, Schlegelberger, Maar, Izbicki, Bockhorn, Schumacher: Establishment and Characterization of a Pair of Patient-derived Human Non-small Cell Lung Cancer Cell Lines from a Primary Tumor and Corresponding Lymph Node Metastasis. in Anticancer research 2016
our data show that human and bovine CEACAM1 can both inhibit NK-cell cytotoxicity although they differ in their intracellular signaling motifs
Data from cultured aortic endothelial cells suggest that CEACAM1 is involved in regulation of vascular endothelial cell reactions to oxidative stress/lipid peroxidation and in regulation of nitric oxide production in large vessels such as aorta.
This data represents the first report of a functional link between CEACAM1 and the VEGFR2 (show KDR Antibodies)/Akt (show AKT1 Antibodies)/eNOS (show NOS3 Antibodies)-mediated vascular permeability pathway.
CEACAM1 has two alleles and serves as a pathogen receptor in cattle.
A 30-day high fat feeding regimen demonstrated that white adipose tissue-derived fatty acids repressed hepatic CEACAM1-dependent regulation of insulin (show INS Antibodies) and lipid metabolism in 3-month-old male C57BL/6J mice.
REVIEW: summarizes the vascular effects of CEACAM1 and focuses on its role in vascular morphogenesis and endothelial barrier regulation
CEACAM1 exacerbates hypoxic cardiomyocyte injury and post-infarction cardiac remodeling by enhancing cardiomyocyte mitochondrial dysfunction and endoplasmic reticulum stress-induced apoptosis.
The increase in total fat mass in Cc1 (show RB1CC1 Antibodies)(-/-) mice is mainly attributed to hyperphagia and reduced spontaneous physical activity. Although the contribution of the loss of CEACAM1 from anorexigenic proopiomelanocortin (show POMC Antibodies) neurons in the arcuate nucleus is unclear, leptin (show LEP Antibodies) resistance and elevated hypothalamic fatty-acid synthase (show FASN Antibodies) activity could underlie altered energy balance in these mice.
Ceacam1 is essential for normal integrin aIIbb3-mediated platelet function; the disruption of mouse Ceacam1 induced moderate integrin aIIbb3-mediated functional defects.
hepatic CEACAM1 expression at fasting is mediated by Pparalpha (show PPARA Antibodies)-dependent mechanisms.
Gram-positive bacteria promote the mRNA expression of CEACAM1 or CEACAM20 in the small intestine. Inflammatory cytokines or butyrate likely participates in such effects of commensal bacteria.
CEACAM1 is a crucial regulator of B-cell survival, influencing B-cell numbers and protective antiviral antibody responses
High-fat diet amplifies the permissive effect of Ceacam1 deletion on renal expression of all renin (show REN Antibodies)-angiotensin system components, PI3K phosphorylation, inflammation, and fibrosis.
Ceacam1L acts as a crucial factor in glioblastoma-initiating cell maintenance and tumorigenesis by activating c-Src (show SRC Antibodies)/STAT3 (show STAT3 Antibodies) signaling. Monomers of the cytoplasmic domain of Ceacam1L bound to c-Src (show SRC Antibodies) and STAT3 (show STAT3 Antibodies) and induced their phosphorylation.
Results report that CEACAM1 was uniquely expressed at high levels in both human neoplastic mast cells (mastocytosis) and medullary thyroid carcinoma cell (MTC (show MT1A Antibodies)) lines, and suggest that the dominantly interacting proteins SHP1 (show PTPN6 Antibodies) or SFK determine whether CEACAM1-L displays a positive or negative role in tumor cells. .
SASH1 (show SASH1 Antibodies) acts through NOTCH1 (show NOTCH1 Antibodies) and its inhibitor DLK1 (show DLK1 Antibodies) in a three-dimensional model of lumenogenesis involving CEACAM1.
CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture.
In enterocytic C2BBe1 cells, Candida albicans caused a transient tyrosine phosphorylation of CEACAM1 and induced higher expression of membrane-bound CEACAM1 and soluble CEACAM6.
We also found that MMP12 (show MMP12 Antibodies) facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 (show MMP12 Antibodies) may facilitate platelet activation through shedding of CEACAM1.
We demonstrate that recombinant Neisseria Opa proteins reconstituted into liposomes retain the ability to recognize and interact with CEACAM1 and 3 in vitro but do not maintain receptor specificity compared to that of Opa proteins natively expressed by Neisseria gonorrhoeae.
use NMR cross-correlation measurements to examine the effect of glycosylation on CEACAM1-IgV dimerization and use residual dipolar coupling (RDC) measurements to characterize the solution structure of the non-glycosylated form.
miRNA-342 Regulates CEACAM1-induced Lumen Formation in a Three-dimensional Model of Mammary Gland Morphogenesis.
The diffuse and cytoplasmic expression of CD66a may involve the early stage of the hepatocellular carcinoma , and the loss of CD66a expression indicates tumor progression.
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
carcinoembryonic antigen-related cell adhesion molecule 1
, carcinoembryonic antigen-related cell adhesion molecule 8
, CEA-related cell adhesion molecule 1
, biliary glycoprotein 1
, biliary glycoprotein D
, carcinoembryonic antigen 1
, carcinoembryonic antigen 7
, hepatitis virus (MHV-4) susceptibility
, hepatitis virus receptor
, murine hepatitis virus receptor
, CD66a antigen
, antigen CD66
, ATP-dependent taurocolate-carrier protein
, C-CAM 105
, CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin)
, bone gamma-carboxyglutamic acid (Gla) protein
, cell-CAM 105