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At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. Additionally we are shipping Chromobox Homolog 3 Kits (35) and Chromobox Homolog 3 Proteins (13) and many more products for this protein.
Showing 10 out of 146 products:
Human Polyclonal CBX3 Primary Antibody for ChIPSeq, IF - ABIN2452035
Kametaka, Takagi, Hayakawa, Haraguchi, Hiraoka, Yoneda: Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins. in Genes to cells : devoted to molecular & cellular mechanisms 2002
Show all 3 Pubmed References
Human Monoclonal CBX3 Primary Antibody for ICC, IF - ABIN2668515
Nielsen, Ortiz, You, Oulad-Abdelghani, Khechumian, Gansmuller, Chambon, Losson: Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. in The EMBO journal 2000
Show all 2 Pubmed References
Human Monoclonal CBX3 Primary Antibody for IF, ELISA - ABIN564925
Lin, Cheng, Yang, Lin, Wang, Lai, Shieh: Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. in Oncogene 2012
Human Polyclonal CBX3 Primary Antibody for IHC (p), IHC - ABIN250816
Vakoc, Mandat, Olenchock, Blobel: Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. in Molecular cell 2005
Human Polyclonal CBX3 Primary Antibody for ICC, IF - ABIN4288454
Yan, Xing, Guo, Fang, Jiao, Guo, Xu, Fang, Holmberg, Nilsson, Liu: Somatostatin derivative (smsDX) targets cellular metabolism in prostate cancer cells after androgen deprivation therapy. in PLoS ONE 2013
Forced expression of HP1gamma facilitated axonal and dendritic development, suggesting that the increase of HP1gamma is a rate limiting step in neuronal maturation.
in addition to histones, bacteria control host transcription by modulating the activity of HP1 (show CBX5 Antibodies) proteins, with potential implications in transcriptional reprogramming at the mucosal barrier.
MeCP2 binding triggers the loss of HP1gamma at the chromosomal domain and an increased HP1gamma mobility.
Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice.
the role of the HP1gamma/G9a (show EHMT2 Antibodies) axis is to retain centromeric regions of unpaired homologous chromosomes in close alignment and facilitate progression of their pairing in early meiotic prophase
identified 4 amino acids (165 to 168) within the chromoshadow domain of Cbx3 that are key elements for Cbx3 interaction with Dia-1 (show CYB5R3 Antibodies)- and Cbx3-induced smooth muscle cell differentiation
The Ca2 (show CA2 Antibodies)+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif.
Results reveal the role of HP1gamma in ESC self-renewal and in the balance between the pluripotent and the differentiation programs.
Findings demonstrate novel role for HP1gamma in transcription activation.
Pax3 (show PAX3 Antibodies) represses transcription through a novel mechanism involving competition between corepressor KAP1 (show TRIM28 Antibodies) and the heterochromatin-binding protein HP1gamma
The deletion of CBX3 directly enforces the expression of CDK6 (show CDK6 Antibodies) and p21 (show CDKN1A Antibodies).
These data indicate that HP1-gamma is a novel epigenetic repressor of epsilon-globin (show HBe1 Antibodies) gene expression.
these data underscore the importance of IDRs 1, 2, and 3 in defining the structural and dynamic properties of HP1gamma, discoveries that have both mechanistic and potentially biomedical relevance.
In contrast to HP1alpha (show CBX5 Antibodies), HP1gamma could not recognize H3K9me3 in extended nucleosomes.
this study identified miR (show MLXIP Antibodies)-30a as a tumor-suppressive microRNA that targets HP1gamma in vitro and in vivo to specifically suppress the growth of colorectal cancer in mouse xenograft models.
BARD1 (show BARD1 Antibodies) interacts with H3K9me2 through HP1 (show DEFA1 Antibodies) and plays a critical role in retention of a BRCA1/BARD1 (show BARD1 Antibodies) complex at the site of DNA damage.
CBX3 and CRABP2 (show CRABP2 Antibodies) expression was markedly increased in lung cancer tissues
our data suggested that HP1gamma plays an important role in promoting non-small cell lung cancer
compartmentalized and total HP1gamma protein expression is increased in PCa (show FLVCR1 Antibodies) and that expression correlates with clinical outcomes better than Gleason score.
HP1gamma affects the spontaneous differentiation potential of P19 (show CDKN2D Antibodies) cells, and might play major roles in the decision of cell fates in pluripotent stem cells.
Dynamic changes of the nuclear-cytoplasmic and subnuclear distribution of members of the Cbx (show CBX1 Antibodies) family may be central to the maternal to embryonic transition.
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
, chromobox homolog 3
, chromobox protein homolog 3
, heterochromatin protein 1 gamma
, heterochromatin protein 1 homolog gamma
, modifier 2 protein
, HP1 gamma homolog
, chromobox homolog 3 (HP1 gamma homolog, Drosophila)
, heterochromatin protein HP1 gamma
, heterochromatin-like protein 1
, chromobox homolog 3 a
, chromobox protein (CHCB2)
, chromobox-like protein 3