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Claudin 4 Proteins (CLDN4)

CLDN4 encodes an integral membrane protein, which belongs to the claudin family. Additionally we are shipping Claudin 4 Antibodies (114) and Claudin 4 Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLDN4 1364 O14493
CLDN4 12740 O35054
Rat CLDN4 CLDN4 304407  
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Top Claudin 4 Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
Human Un-conjugated   2 μg Log in to see 6 Days

CLDN4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Claudin 4 (CLDN4) Interaction Partners

Human Claudin 4 (CLDN4) interaction partners

  1. Results showed overexpression of CLDN4 in endometrial cancer cells. Its intracellular presence coupled with the biphasic effects of E2 on its expression in the cytoskeleton suggest that it may be involved in cell signaling to and from tight junctions.

  2. claudin 1 (show CLDN7 Proteins) and claudin 4 are differentially involved in atopic dermatitis pathogenesis

  3. Results suggested that claudin-4, which was regulated by methylation status, plays an important role in breast cancer growth and malignancy via the control of cell proliferation, migration and apoptosis.

  4. Overexpression of claudin-4 induced formation of vascular channels in breast cancer.

  5. This meta-analysis shows that over-expression of claudin-4 is associated with progress of gastric cancer and poor prognosis of gastric cancer patients.

  6. Data suggest that changes in DNA methylation (show HELLS Proteins) in trophoblasts regulate (1) cell mobility/placentation, (2) expression of claudin-4 (CLDN4) and 4-fucosyltransferase (FUT4 (show FUT4 Proteins)), and (3) matrix metalloproteinase (MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins)) activity.

  7. Data show that claudin-4 and claudin-7 (show CLDN7 Proteins) were observed in hepatocytes of severely damaged mouse and human livers.

  8. increased claudin-3 (show CLDN3 Proteins) and claudin-4 expression may play a postive role in the progression and metastasis of gastric cancer

  9. Studies suggest that claudin-3 (show CLDN3 Proteins) and claudin-4 might be targets for the treatment of chemotherapy-resistant ovarian cancer and other tumors overexpressing claudin-3 (show CLDN3 Proteins) and -4 using Clostridium perfringens enterotoxin (CPE (show CPE Proteins))-based theranostic agents.

  10. Claudin-4 controls the receptor tyrosine kinase (show RET Proteins) EphA2 (show EPHA2 Proteins) pro-oncogenic switch through beta-catenin (show CTNNB1 Proteins)

Mouse (Murine) Claudin 4 (CLDN4) interaction partners

  1. a Grhl2 (show GRHL2 Proteins)/Ovol2 (show OVOL2 Proteins) network controls Cldn4 and Rab25 (show RAB25 Proteins) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia

  2. Data show that claudin-4 and claudin-7 (show CLDN7 Proteins) were observed in hepatocytes of severely damaged mouse and human livers.

  3. The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1 (show PRSS8 Proteins)).

  4. Claudin 4 has little effect on normal lung physiology but may function to protect against acute lung injury in mice.

  5. The results suggest that progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia, and that Cld4 plays an important role in maintaining the homeostatic integrity of normal urothelium.

  6. the results indicate that Grhl2 (show GRHL2 Proteins) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Proteins) and Cldn4, as well as of Rab25 (show RAB25 Proteins), which increases the Cldn4 protein and its localization at TJs

  7. Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3 (show CLDN3 Proteins)/-4 protein suggests structural modifications of the toxin to target specific claudins

  8. Claudin-3 (show CLDN3 Proteins) in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes

  9. Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma.

  10. results suggest that Cld4 is induced by E-protein activity in the later stages of DP cells to increase the efficiency of positive selection, uncovering a hitherto unrecognized function of a Cld (show LMF1 Proteins) family protein

Pig (Porcine) Claudin 4 (CLDN4) interaction partners

  1. Claudin-4 expression shows age-dependent change in cellular localization on pig jejunal villous epithelial cells

  2. These findings indicate that claudin-4 and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.

Claudin 4 (CLDN4) Protein Profile

Protein Summary

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Gene names and symbols associated with Claudin 4 Proteins (CLDN4)

  • claudin 4 (CLDN4)
  • claudin-4-like (LOC100059948)
  • claudin 4 (cldn4)
  • claudin 4 (Cldn4)
  • claudin 4-like (LOC100340963)
  • claudin-4-like (LOC100856416)
  • RIKEN cDNA 4930412D23 gene (4930412D23Rik)
  • similar to claudin 4 (LOC688420)
  • Cep-r protein
  • CLDN4 protein
  • CPE-R protein
  • CPER protein
  • Cpetr protein
  • Cpetr1 protein
  • hCPE-R protein
  • WBSCR8 protein

Protein level used designations for Claudin 4 Proteins (CLDN4)

claudin-4 , claudin 4 , CPE-receptor , Clostridium perfringens enterotoxin receptor 1 , Williams-Beuren syndrome chromosomal region 8 protein , CPE-R , clostridium perfringens enterotoxin receptor , tight junction-associated protein , uncharacterized protein LOC73934

780477 Ovis aries
100059948 Equus caballus
463464 Pan troglodytes
489802 Canis lupus familiaris
549417 Xenopus (Silurana) tropicalis
734640 Xenopus laevis
1364 Homo sapiens
12740 Mus musculus
304407 Rattus norvegicus
395144 Gallus gallus
733578 Sus scrofa
414921 Bos taurus
100720244 Cavia porcellus
100340963 Oryctolagus cuniculus
100856416 Canis lupus familiaris
73934 Mus musculus
688420 Rattus norvegicus
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