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anti-Collagen, Type IV, alpha 3 (COL4a3) Antibodies

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. Additionally we are shipping COL4a3 Kits (12) and COL4a3 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COL4a3 12828 Q9QZS0
COL4a3 363265  
COL4a3 1285 Q01955
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Top anti-COL4a3 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-COL4A3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Liver WB Suggested Anti-COL4A3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL Log in to see 5 to 6 Days
$320.60
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Tumstatin expression in HepG2 colchicine-treated (A), HeLa UV-treated (B), Raw264.7 colchicine-treated (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated IF, ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details

COL4a3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-COL4a3 Antibodies

  1. Human Polyclonal COL4a3 Primary Antibody for IHC, ELISA - ABIN347487 : Thevenard, Ramont, Mir, Dupont-Deshorgue, Maquart, Monboisse, Brassart-Pasco: A new anti-tumor strategy based on in vivo tumstatin overexpression after plasmid electrotransfer in muscle. in Biochemical and biophysical research communications 2013 (PubMed)
    Show all 2 references for ABIN347487

  2. Human Polyclonal COL4a3 Primary Antibody for WB - ABIN611342 : Arcaro, Volinia, Zvelebil, Stein, Watton, Layton, Gout, Ahmadi, Downward, Waterfield: Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. in The Journal of biological chemistry 1999 (PubMed)

More Antibodies against COL4a3 Interaction Partners

Mouse (Murine) Collagen, Type IV, alpha 3 (COL4a3) interaction partners

  1. Report monoclonal antibody against the collagen type IV (show COL4 Antibodies) alpha3NC1 domain as a marker for glomerular disease.

  2. Data show that deletion of tumstatin and TSP1 (show GZMA Antibodies) in p53 (show TP53 Antibodies)-/- mice leads to increased tumor burden and reduced survival.

  3. the pathogenetic role of USAG-1 (show SOSTDC1 Antibodies) in Col4a3-/- mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 (show SOSTDC1 Antibodies) may be a promising therapeutic approach for the treatment of Alport syndrome.

  4. Collagen alpha3(IV) nor alpha4(IV) were detected in the lens capsule 2 weeks postnatal.

  5. Matrix metalloproteinase-9 (show MMP9 Antibodies) generated fragments of procollagen, type IV, alpha 3 has endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth.

  6. Alpha3(IV), alpha4(IV), and alpha5(IV) chains form a complex, which is a heterotrimer, and a defect in complex formation might be one of the molecular mechanisms underlying the pathogenesis of Alport syndrome.

  7. CCR1-mediated recruitment and local activation of macrophages contribute to disease progression in COL4A3-deficient mice. CCR1 is potential therapeutic target for Alport disease or other progressive nephropathies with interstitial macrophage infiltrates.

  8. Upregulation of Lama5 (show LAMA5 Antibodies) transcription and concentration of laminin alpha1 and alpha5 within (Alport)collagen alpha3(IV) knockout glomerular basement membrane thickenings contribute to abnormal permeabilities.

  9. A single immunization of highly denatured recombinant mouse collagen IV (show COL4 Antibodies) alpha 3 chain noncollagen domain induces severe glomerulonephritis in 100% of Wistar Kyoto rats.

Human Collagen, Type IV, alpha 3 (COL4a3) interaction partners

  1. New COL4A3 mutations among Portuguese patients with collagen IV (show COL4 Antibodies)-related nephropathies were identified in 18 unrelated families.

  2. The results support the hypothesis that certain hypomorphic podocin variants may act as adverse genetic modifiers when co-inherited with COL4A3 mutations

  3. Letter/Case Report: novel COL4A3 gene mutations in a consanguineous family with autosomal recessive Alport syndrome.

  4. we identified seven families with associated mutations in COL4A3 and COL4A4 (show Col4a4 Antibodies) genes and four families with associated mutations in COL4A4 (show Col4a4 Antibodies) and COL4A5 (show COL4a5 Antibodies). We did not find kindreds with digenic inheritance attributable to mutations in COL4A3 and COL4A5 (show COL4a5 Antibodies)

  5. Functional studies in cultured podocytes transfected with wild type or mutant COL4A3 chains showed retention of mutant collagens and differential activation of the unfolded protein response cascade.

  6. We found that 7 out of 70 families (10%) with familial focal segmental glomerulosclerosis in our cohort have rare variants in COL4A3 and COL4A4 (show Col4a4 Antibodies).

  7. COL4A3 mutations cause focal segmental glomerulosclerosis.

  8. The expression of collagen type IV (show COL4 Antibodies) and its alpha chains (alpha1-6) was investigated in different endothelial cell culture systems in vitro qualitatively and quantitatively.

  9. A new mutation in the COL4A3 gene responsible for autosomal dominant Alport syndrome, which only generates hearing loss in some carriers

  10. In family 2, a novel COL4A3 missense mutation c.G2290A (p.Gly997Glu) was identified in all affected family members, who had disease ranging from isolated microscopic hematuria to end stage renal disease.

COL4a3 Antigen Profile

Protein Summary

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Gene names and symbols associated with COL4a3

  • collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3) antibody
  • collagen, type IV, alpha 3 (col4a3) antibody
  • collagen, type IV, alpha 3 (Col4a3) antibody
  • alpha3(IV) antibody
  • zTumstatin antibody
  • [a]3(IV) antibody

Protein level used designations for COL4a3

type IV collagen alpha 3 chain , collagen alpha-3(IV) chain , collagen type IV alpha3 chain , procollagen, type IV, alpha 3 , tumstatin , collagen, type IV, alpha 3 (Goodpasture antigen) , collagen IV, alpha-3 polypeptide

GENE ID SPECIES
424797 Gallus gallus
553354 Danio rerio
12828 Mus musculus
363265 Rattus norvegicus
1285 Homo sapiens
317711 Bos taurus
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