COL4a3 antibody (C-Term)

Catalog No. ABIN7266460

Product Details anti-COL4a3 Antibody

Target: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL4a3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: COL4A3 Rabbit pAb

Sequence: SPGSCLEEFR ASPFLECHGR GTCNYYSNSY SFWLASLNPE RMFRKPIPST VKAGELEKII SRCQVCMKKR H

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1600 to the C-terminus of human COL4A3 (NP_000082.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COL4a3

Target: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Alternative Name: COL4A3 (COL4A3 Products)

Synonyms: zTumstatin antibody, [a]3(IV) antibody, alpha3(IV) antibody, collagen type IV alpha 3 chain antibody, collagen, type IV, alpha 3 antibody, COL4A3 antibody, col4a3 antibody, Col4a3 antibody

Background: Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.,COL4A3,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Extracellular Matrix,Collagen,Immunology & Inflammation,Cardiovascular,Angiogenesis,Angiogenic inhibitory factors,COL4A3

Molecular Weight: 135kDa/142kDa/158kDa/161kDa

Gene ID: 1285

UniProt: Q01955

Pathways: Sensory Perception of Sound, Positive Regulation of Endopeptidase Activity