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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Proteins (7) and DNMT3A Kits (2) and many more products for this protein.
Showing 10 out of 208 products:
Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387881
Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999
Show all 12 references for ABIN387881
Human Polyclonal DNMT3A Primary Antibody for EIA, WB - ABIN951957
Park, Zeng, Steer: Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation. in Journal of cardiovascular translational research 2010
Show all 3 references for ABIN951957
Human Polyclonal DNMT3A Primary Antibody for EIA, WB - ABIN951956
Holz-Schietinger, Reich: The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L. in The Journal of biological chemistry 2010
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Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387882
Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999
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Human Monoclonal DNMT3A Primary Antibody for ChIP, WB - ABIN2668262
Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. in Biochemical pharmacology 2011
Human Polyclonal DNMT3A Primary Antibody for WB - ABIN387865
ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. in Biology of reproduction 2012
Human Polyclonal DNMT3A Primary Antibody for IF (p), IHC (p) - ABIN669336
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Antibodies), Dnmt3a, Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
Our findings demonstrated a significant association between DNMT3A rs1550117 A>G polymorphism and increased risk of cancer in three genetic models. Meta-analysis.
DNMT3A mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cells in Acute myeloid leukemia (show BCL11A Antibodies) patients.
DNMT3A R882 mutation is associated with elevated expression of MAFB (show MAFB Antibodies) and M4/M5 immunophenotype of acute myeloid leukemia (show BCL11A Antibodies) blasts.
DNMT3A mutants can block the differentiation of HSCs and leukaemic cells via PRC1 (show PRC1 Antibodies).
DNMT3A mutation was a poor prognostic factor in MLL (show MLL Antibodies)-partial tandem duplication Acute myeloid leukemia (show BCL11A Antibodies).
To correlate DNMTs expression with DNA methylation (show HELLS Antibodies), DNMT1 (show DNMT1 Antibodies), DNMT3A and DNMT3B (show DNMT3B Antibodies) mRNA levels in 5 colorectal cancer cell lines; results suggest that cellular DNMT (show DNMT1 Antibodies) expression is positively correlated with global DNA methylation (show HELLS Antibodies) level but not with regional DNA hypermethylation at each locus.
DNA methyltransferase 3A promotes cell proliferation by silencing CDK (show CDK4 Antibodies) inhibitor p18INK4C (show CDKN2C Antibodies) in gastric carcinogenesis
DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.
Among 864 Dutch persons between 80 and 105.8 years of age, DNA sequence analysis of DNMT3A confirmed a high incidence of somatic mutations but no effect on 10-year survival.
Data suggest that microRNA miR (show MLXIP Antibodies)-101 may inhibit MDA-MB-231 breast cancer cell proliferation and migration by repressing DNA methyltransferase 3a (DNMT3a) expression and up-regulating E-cadherin (show CDH1 Antibodies) expression.
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 Antibodies) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B Antibodies) were associated with several beef quality traits.
The stress-induced Brg1 (show SMARCA4 Antibodies)-G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Antibodies) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
both the PML (show PML Antibodies)-RARA (show RARA Antibodies)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Antibodies) (APL (show FASL Antibodies)) required DNMT3A
Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.
DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B Antibodies) mRNA transcripts.
An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B Antibodies).
knock-outs display loss of DNA methylation (show HELLS Antibodies) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells
These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS Antibodies) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development
Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies.
data suggest that Dnmt3a and Dnmt3b (show DNMT3B Antibodies) are critical to regulate the onset of Igkappa light chain rearrangement during early B-cell development
These correlational data suggest that DNA methylation (show HELLS Antibodies) via Dnmt3a in the hippocampus co-regulates adaptivity of the behavioral response to chronic social defeat stress
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA