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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Proteins (7) and DNMT3A Kits (3) and many more products for this protein.
Showing 10 out of 262 products:
Human Monoclonal DNMT3A Primary Antibody for ChIP, FACS - ABIN266067
Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. in The Journal of biological chemistry 2002
Show all 79 references for ABIN266067
Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387881
Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999
Show all 12 references for ABIN387881
Human Polyclonal DNMT3A Primary Antibody for EIA, WB - ABIN951957
Park, Zeng, Steer: Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation. in Journal of cardiovascular translational research 2010
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Human Polyclonal DNMT3A Primary Antibody for EIA, WB - ABIN951956
Holz-Schietinger, Reich: The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L. in The Journal of biological chemistry 2010
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Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387882
Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999
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Human Polyclonal DNMT3A Primary Antibody for IF (p), IHC (p) - ABIN669336
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
Human Polyclonal DNMT3A Primary Antibody for WB - ABIN387865
ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. in Biology of reproduction 2012
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Antibodies), Dnmt3a, Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
miR (show MLXIP Antibodies)-29b was negatively correlated with DNMT3A/3B expression at the cellular/histological levels.
mRNA and protein expression levels of DNMT3a were upregulated in genotype 1b and 3a HCV-infected hepatocellular carcinoma patients as compared to control. No differences were seen for genotypes 5 and 7.
These results suggested that miR200b has an important role in hepatocarcinogenesis and acts by downregulating DNMT3a expression.
Overexpression of DNMT3A is associated with Hepatocellular Carcinoma.
Our meta-analysis suggested that DNMT1 (show DNMT1 Antibodies) rs16999593 and DNMT3A rs1550117 could contribute to GC and that DNMT3B (show DNMT3B Antibodies) rs1569686 might function as a protective factor against gastric carcinogenesis.
Down-regulation of DNMT3A promotes cell proliferation and invasion of ectopic endometrial stromal cells in adenomyosis.
DNMT3A R882 mutations possessed significant unfavorable prognostic influence on Relapse-free survival and Overall survival in Acute Myeloid Leukemia (show BCL11A Antibodies) patients.
Expression of miR (show MLXIP Antibodies)-26a and miR (show MLXIP Antibodies)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (show ADAMTS7 Antibodies), ATP1B1 (show ATP1B1 Antibodies), COL4A2 (show COL4a2 Antibodies), CPEB3 (show CPEB3 Antibodies), CDK6 (show CDK6 Antibodies), DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
DNMT3A polymorphism plays a major role in the pathogenesis of late-onset Alzheimer's disease and can be used as a stratification marker to predict an individual's susceptibility.
We suggest that 2p23 microdeletion including DNMT3A may cause similar symptoms in patients with DNMT3A mutations and should be considered in patients with overgrowth.
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 Antibodies) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B Antibodies) were associated with several beef quality traits.
Dnmt3a is a haplo-insufficient (show TGFb Antibodies) tumor suppressor in chronic lymphocytic leukemia and highlights the importance of deregulated molecular events in disease pathogenesis.
Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells.
The stress-induced Brg1 (show SMARCA4 Antibodies)-G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Antibodies) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
both the PML (show PML Antibodies)-RARA (show RARA Antibodies)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Antibodies) (APL (show FASL Antibodies)) required DNMT3A
Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.
DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B Antibodies) mRNA transcripts.
An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B Antibodies).
knock-outs display loss of DNA methylation (show HELLS Antibodies) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells
These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS Antibodies) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development
Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA