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anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Antibodies

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Proteins (7) and DNMT3A Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DNMT3A 1788 Q9Y6K1
DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Top anti-DNMT3A Antibodies at antibodies-online.com

Showing 10 out of 262 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of DNMT3A Antibody (C-term) (ABIN387865) in HepG2 cell line lysates (35 µg/lane). DNMT3A (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-DNMT3A Antibody (Center D472) (ABIN387882) in Jurkat cell line lysates (35 µg/lane).DNMT3A(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human kidney tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-Dnmt3a Pab (ABIN387881) in T47-D cell lysate. Dnmt3a (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Lysates from thymus tissue after radiation were subjected to WB using antibody against DNMT3a. CT, control animals. FR, animals subjected to fractionated exposure. AC, acutely exposed animals. All sample loading was normalized to protein content. Representative Western blots from three independent experiments are shown. each lane represents a protein extract of a thymus of one animal. (Mol. Cancer Res. 2005 Oct 01.3(10):553-561) 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-Dnmt3a Antibody (N-term R46) (ABIN387883) in Jurkat cell line lysates (35 µg/lane). Dnmt3a(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Dnmt3a antibody (N-term R46) (ABIN387883), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DNMT3A Antibody (C-term) in CEM cell line lysates (35ug/lane). This demonstrates the DNMT3A antibody detected the DNMT3A protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DNMT3A Antibody (Center) in HL-60 cell line lysates (35ug/lane).This demonstrates the DNMT3A antibody detected the DNMT3A protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ChIP, CyTOF, FACS, ICC, IF, IHC (p), IHC (wm), WB Western blot analysis for Dnmt3a using ABIN266067 at 2 ug/ml against 10 ?g of 293 cell lysate transfected with either mouse Dnmt3a (lane A) or mouse Dnmt3b (lane B). Immuno-staining of Dnmt3a using ABIN266067 at 5 ug/ml dilution on cultured HeLa cells. The nucleic staining is shown in most of the cells. 0.1 mg Log in to see 5 to 7 Days
$473.81
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human breast carcinoma labeled with Anti-Dnmt3a Polyclonal Antibody, Unconjugated (ABIN669336) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-Dnmt3a Polyclonal Antibody, Unconjugated (ABIN669336) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details

DNMT3A Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-DNMT3A Antibodies

  1. Human Monoclonal DNMT3A Primary Antibody for ChIP, FACS - ABIN266067 : Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. in The Journal of biological chemistry 2002 (PubMed)
    Show all 79 references for ABIN266067

  2. Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387881 : Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999 (PubMed)
    Show all 12 references for ABIN387881

  3. Human Polyclonal DNMT3A Primary Antibody for EIA, WB - ABIN951957 : Park, Zeng, Steer: Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation. in Journal of cardiovascular translational research 2010 (PubMed)
    Show all 3 references for ABIN951957

  4. Human Polyclonal DNMT3A Primary Antibody for EIA, WB - ABIN951956 : Holz-Schietinger, Reich: The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN951956

  5. Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387882 : Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999 (PubMed)
    Show all 3 references for ABIN387882

  6. Human Polyclonal DNMT3A Primary Antibody for IF (p), IHC (p) - ABIN669336 : Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015 (PubMed)

  7. Human Polyclonal DNMT3A Primary Antibody for WB - ABIN387865 : ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. in Biology of reproduction 2012 (PubMed)

More Antibodies against DNMT3A Interaction Partners

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Antibodies), Dnmt3a, Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. miR (show MLXIP Antibodies)-29b was negatively correlated with DNMT3A/3B expression at the cellular/histological levels.

  2. mRNA and protein expression levels of DNMT3a were upregulated in genotype 1b and 3a HCV-infected hepatocellular carcinoma patients as compared to control. No differences were seen for genotypes 5 and 7.

  3. These results suggested that miR200b has an important role in hepatocarcinogenesis and acts by downregulating DNMT3a expression.

  4. Overexpression of DNMT3A is associated with Hepatocellular Carcinoma.

  5. Our meta-analysis suggested that DNMT1 (show DNMT1 Antibodies) rs16999593 and DNMT3A rs1550117 could contribute to GC and that DNMT3B (show DNMT3B Antibodies) rs1569686 might function as a protective factor against gastric carcinogenesis.

  6. Down-regulation of DNMT3A promotes cell proliferation and invasion of ectopic endometrial stromal cells in adenomyosis.

  7. DNMT3A R882 mutations possessed significant unfavorable prognostic influence on Relapse-free survival and Overall survival in Acute Myeloid Leukemia (show BCL11A Antibodies) patients.

  8. Expression of miR (show MLXIP Antibodies)-26a and miR (show MLXIP Antibodies)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (show ADAMTS7 Antibodies), ATP1B1 (show ATP1B1 Antibodies), COL4A2 (show COL4a2 Antibodies), CPEB3 (show CPEB3 Antibodies), CDK6 (show CDK6 Antibodies), DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.

  9. DNMT3A polymorphism plays a major role in the pathogenesis of late-onset Alzheimer's disease and can be used as a stratification marker to predict an individual's susceptibility.

  10. We suggest that 2p23 microdeletion including DNMT3A may cause similar symptoms in patients with DNMT3A mutations and should be considered in patients with overgrowth.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The effect of p53 (show TP53 Antibodies) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (show DNMT3B Antibodies) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Dnmt3a is a haplo-insufficient (show TGFb Antibodies) tumor suppressor in chronic lymphocytic leukemia and highlights the importance of deregulated molecular events in disease pathogenesis.

  2. Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells.

  3. The stress-induced Brg1 (show SMARCA4 Antibodies)-G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Antibodies) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  4. both the PML (show PML Antibodies)-RARA (show RARA Antibodies)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Antibodies) (APL (show FASL Antibodies)) required DNMT3A

  5. Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.

  6. DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B Antibodies) mRNA transcripts.

  7. An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B Antibodies).

  8. knock-outs display loss of DNA methylation (show HELLS Antibodies) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells

  9. These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS Antibodies) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development

  10. Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies.

DNMT3A Antigen Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DNMT3A

  • DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) antibody
  • DNA methyltransferase 3A (dnmt3a) antibody
  • DNA (cytosine-5-)-methyltransferase 3 alpha (Dnmt3a) antibody
  • DNA methyltransferase 3A (Dnmt3a) antibody
  • DNMT3A antibody
  • DNMT3A2 antibody
  • M.HsaIIIA antibody
  • MmuIIIA antibody

Protein level used designations for DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPECIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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