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Dynactin 2 (p50) Proteins (DCTN2)

DCTN2 encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Additionally we are shipping Dynamitin Antibodies (72) and Dynamitin Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCTN2 69654 Q99KJ8
DCTN2 10540 Q13561
Rat DCTN2 DCTN2 299850 Q6AYH5
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Top Dynamitin Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,113.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,113.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DCTN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Dynactin 2 (p50) (DCTN2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Dynactin 2 (p50) (DCTN2) interaction partners

  1. Our results suggest a model whereby endocytic activity recruits Dynein to the oocyte cortex. The motor along with its regulators, Dynactin (show DCTN1 Proteins) and Lis1 (show PAFAH1B1 Proteins), functions to ensure efficient endocytic uptake and maturation.

Mouse (Murine) Dynactin 2 (p50) (DCTN2) interaction partners

  1. Altered levels of Cep135 and p50 (show LSP1 Proteins) by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes.

Human Dynactin 2 (p50) (DCTN2) interaction partners

  1. dynamitin is involved in the regulation of Nav1.5 (show SCN5A Proteins) cell-surface density

  2. the determinants of p50 (show CD40 Proteins)/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin (show DCTN1 Proteins) complex

  3. Altered levels of Cep135 and p50 (show CD40 Proteins) by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes.

  4. the Sec23p component of the COPII complex directly interacts with the dynactin (show DCTN1 Proteins) complex through the carboxy-terminal cargo-binding domain of p150(Glued (show DCTN1 Proteins)).

  5. DCTN2 is required in the earliest stages of peroxisome biogenesis.

  6. study does not support a major role for DCTN2 overexpression in carcinogenesis

  7. Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin (show DCTN1 Proteins) and assemble into a complex with its close binding partner, p24.

  8. The interaction between ZW10 (show ZW10 Proteins) and dynamitin showed that the N-terminal region of ZW10 (show ZW10 Proteins) is the major binding site for dynamitin and, like full-length ZW10 (show ZW10 Proteins), could move along microtubules to the centrosomal area in a dynein-dynactin (show DCTN1 Proteins)-dependent manner.

Zebrafish Dynactin 2 (p50) (DCTN2) interaction partners

  1. These results indicate that the p50 (show ARHGEF7 Proteins) component of the dynactin (show DCTN1 Proteins) complex is essential for the survival of sensory neurons and the maintenance of ganglion cell axons, and functions as a major determinant of apicobasal polarity in retinal radial glia.

Dynamitin (DCTN2) Protein Profile

Protein Summary

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with Dynactin 2 (p50) Proteins (DCTN2)

  • dynactin 2 (p50) (DCTN2)
  • dynactin 2 (p50) (dctn2-b)
  • Dynamitin (Dmn)
  • dynactin 2 (p50) (dctn2)
  • dynactin 2 (Dctn2)
  • dynactin 2 (p50) (Dctn2)
  • dynactin 2 (p50) (dctn2-a)
  • 2310042E05Rik protein
  • C87049 protein
  • C130077D06Rik protein
  • CG8269 protein
  • DCTN-50 protein
  • dctn2 protein
  • DCTN50 protein
  • dDyn protein
  • Dmel\\CG8269 protein
  • dmn protein
  • dyna protein
  • DYNAMITIN protein
  • GMP23-48K protein
  • l(2)k16109 protein
  • l(2)k16218 protein
  • p50 protein
  • p50/Dmn protein
  • p50/dynamitin protein
  • RBP50 protein
  • zgc:63867 protein

Protein level used designations for Dynactin 2 (p50) Proteins (DCTN2)

dynactin 2 (p50) , dynactin subunit 2 , dynactin subunit 2-B , dynamitin , CG8269-PA , Dmn-PA , p50-dynamitin , p50 dynamitin , p50/Dynamitin , 50 kDa dynein-associated polypeptide , dynactin complex 50 kDa subunit , growth cone membrane protein 23-48K , 50 kD dynein-associated polypeptide , dynactin complex 50 kD subunit , p50/dynamitin , dynactin subunit 2-A

GENE ID SPECIES
100050464 Equus caballus
100171591 Pongo abelii
380299 Xenopus laevis
44086 Drosophila melanogaster
548423 Xenopus (Silurana) tropicalis
714948 Macaca mulatta
100339187 Oryctolagus cuniculus
100615725 Pan troglodytes
69654 Mus musculus
10540 Homo sapiens
299850 Rattus norvegicus
394141 Danio rerio
447510 Xenopus laevis
395587 Gallus gallus
474415 Canis lupus familiaris
527201 Bos taurus
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