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ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. Additionally we are shipping Endoglin Kits (58) and Endoglin Proteins (49) and many more products for this protein.
Showing 10 out of 718 products:
Human Monoclonal ENG Primary Antibody for FACS - ABIN4896996
Choi, Shin, Lee, Park, Park, Nam, Kim, Woo, Yoon, Kang, Ra, Youn, Hong: Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis. in The journal of gene medicine 2011
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Human Monoclonal ENG Primary Antibody for FACS - ABIN4896992
Narcisi, Cleary, Brama, Hoogduijn, Tüysüz, ten Berge, van Osch: Long-term expansion, enhanced chondrogenic potential, and suppression of endochondral ossification of adult human MSCs via WNT signaling modulation. in Stem cell reports 2015
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Human Monoclonal ENG Primary Antibody for FACS - ABIN4896988
L Ramos, Sánchez-Abarca, Muntión, Preciado, Puig, López-Ruano, Hernández-Hernández, Redondo, Ortega, Rodríguez, Sánchez-Guijo, del Cañizo: MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry. in Cell communication and signaling : CCS 2016
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Horse (Equine) Monoclonal ENG Primary Antibody for FACS - ABIN118831
Haruta, Seon: Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6. in Proceedings of the National Academy of Sciences of the United States of America 1986
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Mouse (Murine) Monoclonal ENG Primary Antibody for FACS - ABIN4896370
Madhu, Li, Dighe, Balian, Cui et al.: BMP-non-responsive Sca1+ CD73+ CD44+ mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone ... in PLoS ONE 2014
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Human Polyclonal ENG Primary Antibody for EIA, WB - ABIN951149
Ríus, Smith, Almendro, Langa, Botella, Marchuk, Vary, Bernabéu: Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. in Blood 1999
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Guinea Pig Polyclonal ENG Primary Antibody for IHC, WB - ABIN2777735
Sanz-Rodriguez, Guerrero-Esteo, Botella, Banville, Vary, Bernabéu: Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins. in The Journal of biological chemistry 2004
Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.
Soluble endoglin did not vary over the pregnancy course or between gestational hypertension, preeclampsia, and control groups.
Serum and placental LXR-alpha (show NR1H3 Antibodies) and endoglin levels were significantly higher in patients with preeclampsia than those in control group (P<0.05, each).
Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (show TGFB1 Antibodies)/Smad2 (show SMAD2 Antibodies) signaling pathway, but not Smad1 (show GARS Antibodies)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.
The novel ENG c.-58G/A substitution in the Endoglin promoter co-segregates with Hereditary hemorrhagic telangiectasia symptoms in a family and appears to affect the transcriptional regulation of the gene, resulting in reduced Endoglin expression.
sEng treatment resulted in an activation of NF-kappaB (show NFKB1 Antibodies), IL-6 (show IL6 Antibodies), suggesting activation of pro-inflammatory phenotype in endothelial cells.
In adolescents with type 1 diabetes mellitus (T1DM), soluble endoglin concentrations might increase in parallel to the deterioration in endothelial function before subclinical structural vascular alterations.
Akt (show AKT1 Antibodies) level was reduced in preeclamptic placentas relative to preterm control. Inhibition of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) resulted in significantly elevated soluble endoglin release from endothelial cells, had no effect on MMP14 (show MMP14 Antibodies) mRNA expression but resulted in significantly reduced TIMP3 (show TIMP3 Antibodies). In contrast inhibiting PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) in placental explants or primary trophoblast did not change soluble endoglin release.
the TGFbeta1 (show TGFB1 Antibodies) coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload
Increased ENG gene expression is associated with the Risk of Hepatocellular Carcinoma.
Endothelial cell-specific endoglin expression in islets of Langerhans is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size.
Study provides evidence that the expression of endoglin is required for the establishment of uterine receptivity and the decidualization process, which mediate embryo adhesion or the attachment reaction.
The changes in CD90 (show THY1 Antibodies) and CD105 expression in the testis and ovary of mice are reported.
the altered immune activity of endoglin deficient macrophages could help to explain the higher rate of infectious diseases seen in HHT1 patients.
These results demonstrate a requirement for endoglin in descendants of Pax3 (show PAX3 Antibodies)-expressing vascular cell precursors.
The similarities in Eng-/- and Mlc2a-/- embryos suggest that Eng-/- mice may suffer from a primary heart developmental defect and secondary defects in vessel patterning.
results of our study provide evidence of endoglin as a valid target for cancer therapy and support further development of plasmid shRNA delivery, which have prolonged antitumor effect, especially in combined schedules
ENG deficiency leads to EC hyperpermeability through constitutive activation of RhoA (show RHOA Antibodies) and destabilization of endothelial barrier function.
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endoglin (Osler-Rendu-Weber syndrome 1)
, CD105 antigen
, cell surface MJ7/18 antigen
, transmembrane glycoprotein