anti-Ewing Sarcoma Breakpoint Region 1 (EWSR1) Antibodies

EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Proteins (4) and EWSR1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EWSR1 14030 Q61545
EWSR1 2130 Q01844
EWSR1 289752  
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Top anti-EWSR1 Antibodies at antibodies-online.com

Showing 10 out of 152 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EWSR1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EWSR1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, WB Western blot analysis of EWSR1 (arrow) using rabbit polyclonal EWSR1 Antibody (C-term) (ABIN658497). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the EWSR1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- EWSR1 Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EWSR1 Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate WB Suggested Anti-EWSR1  Antibody Titration: 0.2-1 µg/mL  Positive Control: Jurkat cell lysate  EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: EWSR1 Antibody [NBP1-28798] - (3.8ug/ml) staining of Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated IP, WB 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IP, IHC, PLA, WB Detection of Human EWS by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (50 and 100 mcg in A, 50 mcg for Input and one 10 cm plate for IP in B) from 293T cells. Antibodies: Affinity purified rabbit anti-EWS antibody ABIN152318 used at 0.2 and 0.1 mcg/ml for WB (A) and at 3 mcg/10 cm plate for IP (B). Immunoprecipitation was also performed with another normal rabbit IgG (Ctrl IgG), anti-EWS antibody and anti-EWS antibody ABIN152319. Detection: Chemiluminescence with exposure times of ~1 second (A) and 10 seconds (B). Western Blot: EWSR1 Antibody [ABIN152318] - Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-EWS antibody used for WB at 0.05 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated EIA, WB   0.4 mL Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details

EWSR1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-EWSR1 Antibodies

  1. Human Polyclonal EWSR1 Primary Antibody for IF, WB - ABIN658497 : Lagirand-Cantaloube, Laud, Lilienbaum, Tirode, Delattre, Auclair, Kryszke: EWS-FLI1 inhibits TNFalpha-induced NFkappaB-dependent transcription in Ewing sarcoma cells. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 5 references for 658497

  2. Human Polyclonal EWSR1 Primary Antibody for ELISA, WB - ABIN1451580 : Delattre, Zucman, Plougastel, Desmaze, Melot, Peter, Kovar, Joubert, de Jong, Rouleau: Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. in Nature 1992 (PubMed)
    Show all 2 references for 1451580

  3. Human Polyclonal EWSR1 Primary Antibody for IP, WB - ABIN152319 : Sohn, Park, Kang, Wu: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. in Biochemical and biophysical research communications 2012 (PubMed)

  4. Human Polyclonal EWSR1 Primary Antibody for ICC, IF - ABIN152318 : Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. in Cancer cell 2006 (PubMed)

  5. Human Polyclonal EWSR1 Primary Antibody for IHC (p), IHC - ABIN449908 : Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. in Cancer research 2006 (PubMed)

  6. Cow (Bovine) Polyclonal EWSR1 Primary Antibody for IHC, WB - ABIN2779045 : Brandal, Panagopoulos, Bjerkehagen, Gorunova, Skjeldal, Micci, Heim: Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma. in Genes, chromosomes & cancer 2008 (PubMed)

More Antibodies against EWSR1 Interaction Partners

Mouse (Murine) Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. EWS is normally O-GlcNAc glycosylated in the brain.

  2. glycosylation of EWS protein

  3. EWSR1 is involved in the post-transcriptional regulation of Uvrag (show UVRAG Antibodies) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  4. EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (show BMP2 Antibodies) and BMP4 (show BMP4 Antibodies) expression.

  5. EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (show PPARGC1A Antibodies) protein stability

  6. both Etv1 (show ETV1 Antibodies) and Ewsr1 were necessary for Fgf10 (show FGF10 Antibodies) expression and elongation of the limb bud.

  7. EWS is involved in post-transcriptional regulation of Col4a1 (show COL4A1 Antibodies) and CTGF (show CTGF Antibodies) via a Drosha (show DROSHA Antibodies)-miRNA-dependent pathway.

  8. These results demonstrate that EWS is essential for early brown fat lineage determination.

  9. Forced expression of EWS/ATF1 (show AFT1 Antibodies) resulted in the development of EWS/ATF1 (show AFT1 Antibodies)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (show AFT1 Antibodies)-driven transformation.

  10. these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.

Zebrafish Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Mutation of the EWS gene modulates Sox9 (show SOX9 Antibodies) gene expression essential for chondrocyte differentiation.

  2. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development

  3. Interaction between EWSR1/FLI1 (show FLI1 Antibodies) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.

Human Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 (show AFT1 Antibodies) gene fusion.

  2. Results expand the spectrum of tumor types harboring EWSR1/FUS (show FUS Antibodies)-ATF1 (show AFT1 Antibodies) gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.

  3. papillary thyroid carcinomas with EWSR1 rearrangement disclosed a lower percentage of nuclei with EWSR1 polysomy than those without EWSR1 rearrangement

  4. The net result of combined lurbinectedin and irinotecan treatment was a complete reversal of EWS-FLI1 (show FLI1 Antibodies) activity and elimination of established tumors in 30% to 70% of mice after only 11 days of therapy. Our results illustrate the preclinical safety and efficacy of a disease-specific therapy targeting the central oncogenic driver in Ewing sarcoma.

  5. Aggregation of FET proteins FUS (show FUS Antibodies), EWSR1, and TAF15 (show TAF15 Antibodies) mediate a pathological change in amyotrophic lateral sclerosis. (Review)

  6. A subgroup of MAML2 (show MAML2 Antibodies) fusion-negative mucoepidermoid carcinomas are actually clear cell carcinoma of the salivary gland with EWSR1 translocation.

  7. Study found consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS-FLI1 (show FLI1 Antibodies) fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewing sarcoma.

  8. Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1 (show CREB1 Antibodies)/CREM (show CREM Antibodies) fusions.

  9. We conclude that in the context of 22q11-12 regional alterations present in SMARCB1 (show SMARCB1 Antibodies)-deleted tumors, simultaneous EWSR1 involvement may be misinterpreted as equivalent to EWSR1 rearrangement. A detailed clinicopathologic correlation and supplementing the EWSR1 FISH assay with complementary methodology is mandatory for correct diagnosis

  10. While our study confirmed that fluorescence in-situ hybridization is a sensitive and specific tool in the diagnosis of EWSR1-associated tumours, atypical fluorescence in-situ hybridization signals and classical rearrangement in entities other than EWSR1-associated tumours can occur

EWSR1 Antigen Profile

Protein Summary

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Gene names and symbols associated with EWSR1

  • Ewing sarcoma breakpoint region 1 (EWSR1) antibody
  • Ewing sarcoma breakpoint region 1 (ewsr1) antibody
  • Ewing sarcoma breakpoint region 1 (Ewsr1) antibody
  • Ewing sarcoma breakpoint region 1a (ewsr1a) antibody
  • EWS RNA-binding protein 1 (EWSR1) antibody
  • EWS RNA-binding protein 1 (Ewsr1) antibody
  • AU018891 antibody
  • bK984G1.4 antibody
  • DKFZp459K1116 antibody
  • Ews antibody
  • Ewsh antibody
  • EWSR1 antibody
  • fc04c01 antibody
  • wu:fc04c01 antibody

Protein level used designations for EWSR1

RNA-binding protein EWS , Ewing sarcoma RNA-binding protein , Ewing sarcoma breakpoint region 1 , Ewing sarcoma homolog , Ewings sarcoma EWS-Fli1 (type 1) oncogene

GENE ID SPECIES
748264 Pan troglodytes
100034010 Equus caballus
100018014 Monodelphis domestica
100173925 Pongo abelii
100550662 Meleagris gallopavo
100557388 Anolis carolinensis
100595788 Nomascus leucogenys
417022 Gallus gallus
609786 Canis lupus familiaris
534073 Bos taurus
14030 Mus musculus
100156911 Sus scrofa
323597 Danio rerio
2130 Homo sapiens
289752 Rattus norvegicus
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