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EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Proteins (4) and EWSR1 Kits (3) and many more products for this protein.
Showing 10 out of 145 products:
Human Polyclonal EWSR1 Primary Antibody for IF, WB - ABIN658497
Lagirand-Cantaloube, Laud, Lilienbaum, Tirode, Delattre, Auclair, Kryszke: EWS-FLI1 inhibits TNFalpha-induced NFkappaB-dependent transcription in Ewing sarcoma cells. in Biochemical and biophysical research communications 2010
Show all 5 references for ABIN658497
Human Polyclonal EWSR1 Primary Antibody for IP, WB - ABIN152319
Sohn, Park, Kang, Wu: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. in Biochemical and biophysical research communications 2012
Human Polyclonal EWSR1 Primary Antibody for ICC, IF - ABIN152318
Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. in Cancer cell 2006
Human Polyclonal EWSR1 Primary Antibody for IHC (p), IHC - ABIN449908
Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. in Cancer research 2006
Human Polyclonal EWSR1 Primary Antibody for EIA, WB - ABIN453643
Bhagirath, Abe, Nojima, Yoshida: Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma. in Genes, chromosomes & cancer 1995
Cow (Bovine) Polyclonal EWSR1 Primary Antibody for IHC, WB - ABIN2779045
Brandal, Panagopoulos, Bjerkehagen, Gorunova, Skjeldal, Micci, Heim: Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma. in Genes, chromosomes & cancer 2008
EWS is normally O-GlcNAc glycosylated in the brain.
glycosylation of EWS protein
EWSR1 is involved in the post-transcriptional regulation of Uvrag (show UVRAG Antibodies) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (show BMP2 Antibodies) and BMP4 (show BMP4 Antibodies) expression.
EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (show PPARGC1A Antibodies) protein stability
both Etv1 (show ETV1 Antibodies) and Ewsr1 were necessary for Fgf10 (show FGF10 Antibodies) expression and elongation of the limb bud.
EWS is involved in post-transcriptional regulation of Col4a1 (show COL4A1 Antibodies) and CTGF (show CTGF Antibodies) via a Drosha (show DROSHA Antibodies)-miRNA-dependent pathway.
These results demonstrate that EWS is essential for early brown fat lineage determination.
Forced expression of EWS/ATF1 (show AFT1 Antibodies) resulted in the development of EWS/ATF1 (show AFT1 Antibodies)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (show AFT1 Antibodies)-driven transformation.
these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.
Mutation of the EWS gene modulates Sox9 (show SOX9 Antibodies) gene expression essential for chondrocyte differentiation.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Interaction between EWSR1/FLI1 (show FLI1 Antibodies) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
We conclude that in the context of 22q11-12 regional alterations present in SMARCB1 (show SMARCB1 Antibodies)-deleted tumors, simultaneous EWSR1 involvement may be misinterpreted as equivalent to EWSR1 rearrangement. A detailed clinicopathologic correlation and supplementing the EWSR1 FISH assay with complementary methodology is mandatory for correct diagnosis
While our study confirmed that fluorescence in-situ hybridization is a sensitive and specific tool in the diagnosis of EWSR1-associated tumours, atypical fluorescence in-situ hybridization signals and classical rearrangement in entities other than EWSR1-associated tumours can occur
EWSR1 regulates the acetylation of microtubules in a cell cycle-dependent manner through its dynamic location on spindle MTs (show TIMM8A Antibodies), and may be a novel regulator for mitosis progress independent of its translocation.
Studies provide evidence that FUS/TLS (show FUS Antibodies), EWS and TAF15 (show TAF15 Antibodies) proteins play a major role in neurodegenerative disorders. (review).
We identified EWSR1 rearrangement in 25% of Ectomesenchymal chondromyxoid tumour
EWSR1-related rearrangement was detected extraskeletal myxoid chondrosarcoma
a novel EWSR1/ETS (show ETS1 Antibodies) chimeric gene, was identified in a patient diagnosed with refractory AML (show RUNX1 Antibodies), suggesting a potential role of leukemogenesis in rare cases of AML (show RUNX1 Antibodies). This fusion gene is very likely to exhibit oncogenic potential by interfering with the p53 (show TP53 Antibodies)/p21 (show CDKN1A Antibodies)-dependent pathway.
LRWD1 (show LRWD1 Antibodies) is a novel regulator of EWS-FLI1 (show FLI1 Antibodies) driven cell proliferation in Ewing sarcoma cells. EWS-FLI1 (show FLI1 Antibodies) regulates LRWD1 (show LRWD1 Antibodies) expression and LRWD1 (show LRWD1 Antibodies) may contribute to EWS-FLI1 (show FLI1 Antibodies) mediated transcriptional repression.
Ewing sarcoma may be susceptible to treatment with epigenetic inhibitors blocking BRD3 (show BRD3 Antibodies)/4 activity and the associated pathognomonic EWS-FLT1 (show FLT1 Antibodies) transcriptional program.
prevalence of the FUS (show FUS Antibodies)-ERG (show ERG Antibodies) gene fusion in a large cohort of pathologically and molecularly well characterized small blue round cell tumors, lacking other known gene rearrangements
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
RNA-binding protein EWS
, Ewing sarcoma RNA-binding protein
, Ewing sarcoma breakpoint region 1
, Ewing sarcoma homolog
, Ewings sarcoma EWS-Fli1 (type 1) oncogene