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The protein encoded by FBLN5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. Additionally we are shipping Fibulin 5 Kits (34) and Fibulin 5 Proteins (15) and many more products for this protein.
Showing 10 out of 135 products:
Human Monoclonal Fibulin 5 Primary Antibody for IHC, ELISA - ABIN969131
Markova, Zou, Ringpfeil, Sasaki, Kostka, Timpl, Uitto, Chu: Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene. in American journal of human genetics 2003
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Human Monoclonal Fibulin 5 Primary Antibody for IHC, ELISA - ABIN969144
Wen, Hochholdinger, Sauer, Bruce, Schnable: The roothairless1 gene of maize encodes a homolog of sec3, which is involved in polar exocytosis. in Plant physiology 2005
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Human Monoclonal Fibulin 5 Primary Antibody for ELISA, WB - ABIN969145
Kadoya, Sasaki, Kostka, Timpl, Matsuzaki, Kumagai, Sakai, Nishiyama, Amano: Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis. in The British journal of dermatology 2005
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Human Monoclonal Fibulin 5 Primary Antibody for EIA, IHC (p) - ABIN1107240
Lee, Roy, Mogford, Schiemann, Mustoe: Fibulin-5 promotes wound healing in vivo. in Journal of the American College of Surgeons 2004
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Human Polyclonal Fibulin 5 Primary Antibody for ELISA, WB - ABIN185699
Albig, Neil, Schiemann: Fibulins 3 and 5 antagonize tumor angiogenesis in vivo. in Cancer research 2006
Data show that fibulin-5 strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1 (show ANGPT1 Antibodies)/TIE-2 (show TEK Antibodies) receptor axis.
FBLN5 downregulation in human abdominal aortic aneurysm could contribute to extracellular matrix remodeling induced by the inflammatory component of the disease.
Identify a SOX9 (show SOX9 Antibodies)/HDAC (show HDAC3 Antibodies)-dependent mechanism involved in the down-regulation of FBLN5 by inflammation in abdominal aortic aneurysms.
We also found that Fibulin-5 reduces the level of expression of Ki-67 (show MKI67 Antibodies), a nuclear protein (show RDBP Antibodies) associated with cell proliferation. Moreover, reduction in Fibulin-5 expression corresponds to an increase of Ki-67 (show MKI67 Antibodies) detection in breast tissue samples
study demonstrates the pivotal role of the extracellular protein, fibulin-5, on the adhesion and proliferation of human keloid-derived cells, through binding to integrin beta-1 (show ITGB1 Antibodies)
Lower FBLN-5 expression is an important indicator of poor survival in hepatocellular carcinoma. FBLN-5 inhibits HCC (show FAM126A Antibodies) adhesion/motility via integrin-dependent mechanism.
FBLN5 mRNA expression is upregulated in response to cAMP-mediated decidualization of primary human endometrial stromal cells, although FBLN5 itself does not enhance decidualization
Fibulin-5 is significantly down-regulated in ovarian carcinoma and acts as a tumour suppressor by inhibiting the migration and invasion of ovarian cancer cells.
Data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM (show MMRN1 Antibodies) interactions to reduce ROS (show ROS1 Antibodies) production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease.
Data suggest that fibulin-5 functions as a metastasis suppressor in lung cancer by modulating tumor microenvironment to suppress Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
therapy-induced hypoxia elevated Fbln5 expression, whereas pharmacologic inhibition of TGF-beta (show TGFB1 Antibodies) signaling reduced Fbln5 expression. These findings offer insight into the signaling axis that induces Fbln5 expression in PDA and a potential strategy to block its production
While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative.
Fibulin-5 plays critical roles in proliferation, migration and invasion of certain tumors, and the effect of fibulin-5 on tumorigenesis appears to be largely context-dependent. (Review)
These results are consistent with a role for TGFbeta2 in lung septation and for Ltbp4 (show LTBP4 Antibodies) in regulating fibulin-5 dependent elastic fiber assembly.
Without LTBP-4 (show LTBP4 Antibodies), fibulin-5 and tropoelastin (show ELN Antibodies) deposition was discontinuous and punctate in vitro and in vivo
This study used the maturation of fibulin-5 knockout (KO) and wild-type mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries.
suggest that uPA (show PLAU Antibodies) promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin (show PLG Antibodies), which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility
MMP9 (show MMP9 Antibodies) and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans
These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 (show LTBP2 Antibodies) regulates targeting of DANCE on suitable microfibrils to form elastic fibers.
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
, fibulin 5
, developmental arteries and neural crest EGF-like protein
, urine p50 protein
, embryonic vascular EGF repeat-containing protein