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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Additionally we are shipping Friend Leukemia Virus Integration 1 Proteins (7) and Friend Leukemia Virus Integration 1 Kits (6) and many more products for this protein.
Showing 10 out of 165 products:
Human Monoclonal FLI1 Primary Antibody for IP, WB - ABIN967450
Bailly, Bosselut, Zucman, Cormier, Delattre, Roussel, Thomas, Ghysdael: DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. in Molecular and cellular biology 1994
Show all 2 Pubmed References
Human Monoclonal FLI1 Primary Antibody for IP, WB - ABIN967451
May, Lessnick, Braun, Klemsz, Lewis, Lunsford, Hromas, Denny: The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. in Molecular and cellular biology 1994
Show all 2 Pubmed References
Human Polyclonal FLI1 Primary Antibody for IHC (p), IHC - ABIN153424
Radic-Sarikas, Tsafou, Emdal, Papamarkou, Huber, Mutz, Toretsky, Bennett, Olsen, Brunak, Kovar, Superti-Furga: Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities. in Molecular cancer therapeutics 2017
Cow (Bovine) Polyclonal FLI1 Primary Antibody for WB - ABIN2780392
van den Akker, van Dijk, Schmidt, Felida, Beug, Loewenberg, von Lindern: The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity. in Biological chemistry 2004
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Fusion of short fragments of EWSR1 (show EWSR1 Antibodies) to FLI1 is sufficient to recapitulate BAF (show BANF1 Antibodies) complex retargeting and EWS (show EWSR1 Antibodies)-FLI1 activities; studies thus demonstrate that the physical properties of prion (show PRNP Antibodies)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.
In American cutaneous leishmaniasis caused by Leishmania braziliensis infection, MMP1 (show MMP1 Antibodies) is regulated by factors other than FLI1, and the influence of IL-6 (show IL6 Antibodies) on MMP1 (show MMP1 Antibodies) was independent of its effect on FLI1.
epithelial Fli1 deficiency might be involved in the systemic autoimmunity and selective organ fibrosis in systemic sclerosis (SSc (show CYP11A1 Antibodies)).
Study found consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS (show EWSR1 Antibodies)-FLI1 fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewing sarcoma.
loss of ERG (show ERG Antibodies) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
study shows that FLI-1 is expressed variably in different subtypes of NSCLC, and its expression is related to clinicopathologic parameters and poorer prognosis
ERG (show ERG Antibodies) (or FLI1 if available) is useful marker for the diagnosis of Phosphaturic mesenchymal tumors.
FLI1 and MMP9 (show MMP9 Antibodies) position differently in prostate cancer than in normal tissue and prostate hyperplasia, whereas MMP2 (show MMP2 Antibodies) is repositioned in both prostate cancer and hyperplasia.
FLI1 promoter hypermethylation is associated with Colorectal Cancer.
Concurrent exogenous expression of three transcription factors, GATA1 (show GATA1 Antibodies), FLI1 and TAL1 (show TAL1 Antibodies), enables large-scale production of megakaryocytes from human pluripotent stem cells.
These results provide the first evidences that Fli-1 positively regulates LPS (show TLR4 Antibodies)-induced IL-27 (show IL27 Antibodies) production in macrophages
protective against nephritis MRL/lpr (show FAS Antibodies) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (show ETS1 Antibodies) and FLI1.
Simultaneous downregulation of KLF5 (show KLF5 Antibodies) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (show GATA2 Antibodies) are upstream regulators of SMAD1 (show SMAD1 Antibodies) and SMAD5 (show SMAD5 Antibodies) expression in endothelial cells.
These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine (show CCL1 Antibodies) MCP-1 (show CPT1B Antibodies).
Fli-1 directly increases the expression of IL-6 (show IL6 Antibodies) via promoter region binding. This represents one possible mechanism for the protective effect of decreased Fli-1 expression in lupus.
mesodermal Wnt3a (show WNT3A Antibodies)-mediated signaling via the transcription factor Lef1 (show LEF1 Antibodies) positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (show GATA1 Antibodies) expression) in zebrafish embryos.
Fli+ etsrp (show ETV2 Antibodies)+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (show GATA1 Antibodies) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp (show ETV2 Antibodies), demonstrated that erg (show KCNH2 Antibodies) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (show CDH5 Antibodies)
Interaction between EWSR1 (show EWSR1 Antibodies)/FLI1 and EWSR1 (show EWSR1 Antibodies) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Friend leukemia virus integration 1
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, proto-oncogene Fli-1
, transcription factor ERGB
, retroviral integration site protein Fli-1 homolog
, retroviral integration site protein Fli-1
, fli-1 proto-oncogene