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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 5 Kits (16) and Metabotropic Glutamate Receptor 5 Proteins (7) and many more products for this protein.
Showing 10 out of 153 products:
Human Polyclonal Metabotropic Glutamate Receptor 5 Primary Antibody for EIA, WB - ABIN358930
Pacheco, Ciruela, Casadó, Mallol, Gallart, Lluis, Franco: Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation. in The Journal of biological chemistry 2004
Show all 5 references for ABIN358930
Human Polyclonal Metabotropic Glutamate Receptor 5 Primary Antibody for WB - ABIN390320
Corti, Clarkson, Crepaldi, Sala, Xuereb, Ferraguti: Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells. in The Journal of biological chemistry 2003
Show all 3 references for ABIN390320
Dog (Canine) Polyclonal Metabotropic Glutamate Receptor 5 Primary Antibody for IHC (fro), IF - ABIN783986
Francesconi, Kumari, Zukin: Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
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Mouse (Murine) Polyclonal Metabotropic Glutamate Receptor 5 Primary Antibody for ICC, IHC - ABIN1742080
Ferraguti, Shigemoto: Metabotropic glutamate receptors. in Cell and tissue research 2006
Human Monoclonal Metabotropic Glutamate Receptor 5 Primary Antibody for IP, IHC - ABIN1027721
Keinänen, Wisden, Sommer, Werner, Herb, Verdoorn, Sakmann, Seeburg: A family of AMPA-selective glutamate receptors. in Science (New York, N.Y.) 1990
Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P (show TAC1 Antibodies) immunoreactivity in Huntington's disease
The metabotropic glutamate (show GRIN1 Antibodies) receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders.
The interaction between GRM5 and cellular prion protein (show PRNP Antibodies) has a central role in transgenic mouse model of Alzheimer's disease pathogenesis.
Data suggest that metabotropic glutamate receptors recycling is completely dependent on the activity of PP2A whereas, PP2B has partial effect on this process.
findings provide evidence for decreased expression of metabotropic glutamate receptor 5 and its signaling components representing a key pathophysiological hallmark in autism spectrum disorder.
Study provided evidence that protein expression of mGluR5 is significantly higher (total: 42%; monomer: 25%; dimer: 52%) in the hippocampal CA1 (show CA1 Antibodies) region of schizophrenia subjects relative to healthy controls
Results provide compelling evidence that mGluR5 regulation is altered in schizophrenia, likely contributing to the altered glutamatergic signaling that is associated with the disorder
This review supports altered mGluR5 functioning as a convergent point in ASD (show ARSD Antibodies) pathogenesis and indicates more research is warranted into mGluR5 as a potential therapeutic target.
both an increased and reduced mGlu5 functioning seem to be associated with Intellectual Disability and autism spectrum disorders.
Findings suggest that mGluR2 (show GRM2 Antibodies)/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia
mGluR5 may mediate amyloid beta synaptotoxicity and it is a novel therapeutic targets for AD and other cognitive syndromes.
Dysregulation of fragile X mental retardation protein (show NUFIP2 Antibodies)-metabotropic glutamate receptor 5 signaling pathway, accompanied with a downregulation of GABA(A) receptor beta3 subunit expression, may contribute to the 'autistic-like' features knockout mice.
Our findings suggest a fundamental role for mGluR5 in the development of Pv(+) neurons and show that alterations in this system can produce broad-spectrum alterations in brain network activity
This work provides strong evidence that Homer (show HOMER1 Antibodies)-mGlu5 binding contributes to symptoms associated with neurodevelopmental disorders
This study identify highly specialized roles of lateral septal mGluR5 and Oxtr (show OXTR Antibodies) in the the regulation of discrete social behaviors, and suggest that deficits in social interactions.
Results offer the first evidence that changes in the striatal expression of mGlu4 (show GRM4 Antibodies) and mGlu5 receptors occur in acute models of parkinsonisms
We show for the first time that knockdown of mGlu5 in the dorsal hippocampus is sufficient to impair spatial learning in Morris Water Maze
The results of this study demonstrated an important role for mGlu5 in environmental modulation of schizophrenia-related behavioral impairments.
chronic postnatal down-regulation of mGluR5 signaling produces coordinated impairments in both NMDAR (show GRIN1 Antibodies)-dependent LTD in vitro and ocular dominance plasticity in vivo.
mGluR5 blockage elicits distinct outcomes in terms of locomotor activity and motor coordination depending on the brain region injected with mGluR5 antagonist.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
metabotropic glutamate receptor 5
, metabotropic glutamate receptor 5 variant F
, metabotropic glutamate receptor 5 variant G
, metabotropic glutamate receptor 5 variant H
, metabotropic glutamate receptor (mGluR5)
, metabotropic glutamate receptor 5b
, G protein coupled receptor, family C, group 1, member E
, G protein-coupled receptor GRM5
, G protein-coupled receptor, family C, group 1, member E
, metabotropic glutamate receptor subtype 5b
, metabotropic glutamate receptor type 5