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IQGAP2 encodes a member of the IQGAP family. Additionally we are shipping IQGAP2 Kits (5) and IQGAP2 Proteins (3) and many more products for this protein.
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Suppression of XIQGAP2 expression caused ectodermal lesions in the neurula stage embryos.
Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/b-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease.
we identified IQGAP2 as a human and zebrafish podocyte gene product that is downregulated in microarray data sets from kidney biopsies of human patients with focal segmental glomerulosclerosis and minimal change nephrotic syndrome.
Data show that IQ motif-containing GTPase-activating protein 2 (IQGAP2) expression is altered in colitis.
IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review)
Low IQGAP2 expression was associated with hepatocellular carcinoma.
The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin (show CALM1 Antibodies) in the absence of calcium.
observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer
increased IQGAP1 (show IQGAP1 Antibodies) and/or decreased IQGAP2 contribute to the pathogenesis of human HCC (show FAM126A Antibodies).
The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase (show RACGAP1 Antibodies)-activating-like protein (IQGAP2).
The gene for the putative rac1/cdc42 effector (show FNBP1L Antibodies) protein IQGAP2 was found in the PAR (show JTB Antibodies) gene cluster at 5q13, flanked by PAR1 (show MARK2 Antibodies) & encompassing PAR3 (show F2RL2 Antibodies). It functions as a GTP (show AK3 Antibodies)-dependent effector protein in thrombin (show F2 Antibodies)-induced platelet cytoskeletal reorganization.
Data show that complete loss of IQ motif-containing GTPase-activating protein 2 (IQGAP2) gene leads to protection from dextran sulfate sodium (DSS (show PMP22 Antibodies))-induced colitis.
Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
Phosphoinositide module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)).
murine IQGAP2 selectively regulates the facilitated phase of hepatic fatty acid uptake both in vitro and in vivo
Development of hepatocellular carcinoma in Iqgap2-deficient mice is Iqgap1 (show IQGAP1 Antibodies) dependent.
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.
IQ motif containing GTPase activating protein 2
, ras GTPase-activating-like protein IQGAP2-like
, ras GTPase-activating-like protein IQGAP2