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In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Additionally we are shipping and many more products for this protein.
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Human Polyclonal INSC Primary Antibody for EIA, IHC (p) - ABIN952909
Hanna, Kruskal, Ezekowitz, Bloom, Collier: Role of macrophage oxidative burst in the action of anthrax lethal toxin. in Molecular medicine (Cambridge, Mass.) 1996
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Human Polyclonal INSC Primary Antibody for IHC (p), WB - ABIN952908
Izaki, Kamakura, Kohjima, Sumimoto: Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. in Biochemical and biophysical research communications 2006
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Studies indicate that the Inscuteable (Insc)and NuMA (show NUMA1 Antibodies) are mutually exclusive interactors of LGN (show GPSM2 Antibodies).
mInsc-LGN (show GPSM2 Antibodies) interaction is vital for stabilization of LGN (show GPSM2 Antibodies) and for intracellular localization of mInsc.
These data present AGS3 (show GPSM1 Antibodies), G-proteins, and mInsc as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies.
cloning of two distinct cDNAs from Insc gene, which is differentially expressed from alternative first exons;Insc proteins bind to the Pins homologues LGN (show GPSM2 Antibodies) and AGS3 (show GPSM1 Antibodies), and also to Par3 (show F2RL2 Antibodies) and Par3beta (show PARD3B Antibodies)
Excess mINSC drives symmetric cell division, more stem cells and enhanced mammary outgrowth.
Data (including data from studies using embryonic stem cell line) suggest that expression of Insc (inscuteable cell cycle protein) is up-regulated by c-Rel (show NFkBP65 Antibodies) in cell differentiation; minimum transcriptional regulatory element (354 bases) was identified.
support for the hitherto untested model that Par3 (show F2RL2 Antibodies)-mInsc and Galphai3 (show GNAI3 Antibodies) act cooperatively to polarize LGN (show GPSM2 Antibodies) and promote perpendicular divisions
Insc controls directional migration via noncanonical G protein signaling, in which Gbetagamma-free Galphai-GDP, a product from Galphai-GTP (show AK3 Antibodies) released after receptor activation, plays a central role.
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006
protein inscuteable homolog