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ITGA2B encodes integrin alpha chain 2b. Additionally we are shipping Integrin Alpha2b Kits (10) and Integrin Alpha2b Proteins (9) and many more products for this protein.
Showing 10 out of 526 products:
Mouse (Murine) Monoclonal CD41 Primary Antibody for FACS - ABIN320117
NOYES, DOMM, WILLSLC: Regulation of erythropoiesis. I. Erythropoietin assay as a clinical tool. in Blood 1970
Show all 9 references for ABIN320117
Human Monoclonal CD41 Primary Antibody for FACS - ABIN94107
Debili, Robin, Schiavon, Letestu, Pflumio, Mitjavila-Garcia, Coulombel, Vainchenker: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. in Blood 2001
Show all 4 references for ABIN94107
Mouse (Murine) Monoclonal CD41 Primary Antibody for FACS - ABIN320114
Nieswandt, Echtenacher, Wachs, Schröder, Gessner, Schmidt, Grau, Männel: Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. in Blood 1999
Show all 4 references for ABIN320114
Human Monoclonal CD41 Primary Antibody for FACS - ABIN94106
Zhang, Varas, Stadtfeld, Heck, Faust, Graf: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. in Experimental hematology 2007
Show all 4 references for ABIN94106
Human Monoclonal CD41 Primary Antibody for FACS - ABIN638432
Ferkowicz, Starr, Xie, Li, Johnson, Shelley, Morrison, Yoder: CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. in Development (Cambridge, England) 2003
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Human Polyclonal CD41 Primary Antibody for IF (p), IHC (p) - ABIN748358
Mei, Yin, Jin, He, Yin: The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. in Endocrinology 2013
Show all 3 references for ABIN748358
Mouse (Murine) Monoclonal CD41 Primary Antibody for FACS - ABIN320115
Zanzinger, Schellack, Nausch, Cerwenka: Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes. in Immunology 2009
Show all 2 references for ABIN320115
Human Monoclonal CD41 Primary Antibody for FACS - ABIN118660
Michelson, Page, Casey, Trucksess, Love, Milstien, Wilson, Massaquoi, Crofford, Hallett: An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. in The Journal of rheumatology 1995
Show all 2 references for ABIN118660
Human Monoclonal CD41 Primary Antibody for FACS, IHC - ABIN1724823
Nurden, Fiore, Nurden, Pillois: Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. in Blood 2011
Show all 2 references for ABIN1724823
Human Monoclonal CD41 Primary Antibody for FACS - ABIN118657
Hornby, Brown, Wilkinson, Mattock, Authi: Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIa. in British journal of haematology 1992
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ITGA2b (show ITGA2B Antibodies) expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b (show ITGA2B Antibodies) levels reflect variation in exposure to activation signals.
Thrombopoietin (show THPO Antibodies)/MPL (show MPL Antibodies) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Antibodies) leukemia.
Direct binding of kindlin-3 (show FERMT3 Antibodies) to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.
ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.
reduction of talin-beta3 integrin (show ITGB3 Antibodies) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding
deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation.
Platelets lacking ERp57 (show PDIA3 Antibodies) have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57 (show PDIA3 Antibodies), implicating surface ERp57 (show PDIA3 Antibodies) in platelet aggregation.
Data indicate that Pyk2 (show PTK2B Antibodies) is a common signaling effector downstream of both G12 (show TCF3 Antibodies)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen.
identified Hic-5 (show TGFB1I1 Antibodies) as a novel and specific regulatory factor for thrombin (show F2 Antibodies)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.
This study shows correlation of blood clot (show TXNDC17 Antibodies) stiffness with platelet integrin alpha-IIb (show ITGA2B Antibodies) beta3 activity, aspirin usage, and transfusion risk in cardiopulmonary bypass patients.
Data show that immune thrombocytopenia (ITP (show ITPA Antibodies)) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins.
Data suggest that the ligand AGDV tetrapeptide binds to ITGB3/GPIIIa (show ITGB3 Antibodies) subunit and induces complete opening of headpiece of integrin alphaIIb/beta3 complex; AGDV appears to have very little contact with ITGA2B/GPIIb (show ITGA2B Antibodies) subunit.
Analysis showed a protective effect of TT genotype of ITGA2 (show ITGA2 Antibodies) 807 C/T on fibrosis progression rate in Chronic Hepatitis C patients.
Report novel ITGA2B (show ITGA2B Antibodies) mutations causing Glanzmann thrombasthenia.
Ibrutinib causes GPVI (show GP6 Antibodies) and integrin alphaIIbbeta3 platelet signaling deficiencies that result in formation of unstable thrombi and may contribute toward bleeding.
Data indicate 114 novel missense variants in integrin alpha 2b (ITGA2B (show ITGA2B Antibodies)) and 68 novel missense variants in integrin beta 3 (ITGB3 (show ITGB3 Antibodies)).
Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb (show ITGA2B Antibodies)/GPIIIa (show ITGB3 Antibodies) complex transmembrane/C-terminal domains and talin-1 (show TLN1 Antibodies) in cell membrane environment during platelet activation.
Anionic lipids in annular positions stabilize the alphaIIbbeta3 transmembrane complex by up to 0.50 +/- 0.02 kcal/mol (show DUOXA1 Antibodies) relative to zwitterionic lipids in a headgroup structure-dependent manner.
ITGA2B (show ITGA2B Antibodies) rs5911 GG genotype is associated with decreased ex vivo antiplatelet activity of ticagrelor in healthy Chinese male subjects.
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
, GPalpha IIb
, alpha IIb
, integrin alpha-IIb
, platelet glycoprotein IIb of IIb/II Ia complex
, platelet membrane glycoprotein IIb
, platelet fibrinogen receptor, alpha subunit
, platelet-specific antigen BAK