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anti-Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Antibodies

ICMT encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. Additionally we are shipping Isoprenylcysteine Carboxyl Methyltransferase Proteins (6) and Isoprenylcysteine Carboxyl Methyltransferase Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ICMT 23463 O60725
ICMT 57295 Q9EQK7
ICMT 170818  
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Top anti-Isoprenylcysteine Carboxyl Methyltransferase Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB The anti-ICMT Pab (ABIN389122) is used in Western blot to detect ICMT in T47D (left) and SK-BR-3 (right) tissue lysate 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB ICMT antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 8 to 10 Days
$815.83
Details

ICMT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Top referenced anti-Isoprenylcysteine Carboxyl Methyltransferase Antibodies

  1. Human Polyclonal ICMT Primary Antibody for EIA, WB - ABIN357792 : Bergo, Gavino, Hong, Beigneux, McMahon, Casey, Young: Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. in The Journal of clinical investigation 2004 (PubMed)
    Show all 3 references for ABIN357792

  2. Chicken Polyclonal ICMT Primary Antibody for WB - ABIN2773889 : Nuthalapaty, Lu, Ramin, Nuthalapaty, Ramin, Ramsey: Is there a preferred gestational age threshold of viability?: a survey of maternal-fetal medicine providers. in The journal of maternal-fetal & neonatal medicine 2007 (PubMed)
    Show all 2 references for ABIN2773889

  3. Human Polyclonal ICMT Primary Antibody for WB - ABIN389122 : Dai, Choy, Chiu, Romano, Slivka, Steitz, Michaelis, Philips: Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. in The Journal of biological chemistry 1998 (PubMed)

More Antibodies against Isoprenylcysteine Carboxyl Methyltransferase Interaction Partners

Human Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.

  2. impact of Icmt on tumorigenic processes

  3. Silencing ICMT in osteosarcoma cells decreas (show NOTCH1 Antibodies)ed Notch1 signaling in (show PDX1 Antibodies)response to stimulation with cell-surface ligands.

  4. a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.

  5. modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma (show ARHGEF16 Antibodies) cells

  6. ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells.

  7. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (show RACGAP1 Antibodies) methylation and activation and its downstream antiapoptotic signaling pathway.

  8. These studies identify isoprenylcysteine carboxyl methyltransferase as a potential target for reducing the growth of K-Ras (show HRAS Antibodies)- and B-Raf (show SNRPE Antibodies)-induced malignancies.

  9. ICMT inhibition induces endothelial cell apoptosis through GRP94 (show HSP90B1 Antibodies)

  10. Icmt traverses the Eendoplasmic reticulum membrane eight times, with both N and C termini disposed toward the cytosol and with a helix-turn-helix structure comprising transmembrane (TM) segments 7 and 8.

Mouse (Murine) Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.

  2. ICMT deficiency precisely phenocopied Notch1 (show NOTCH1 Antibodies) deficiency in the Pdx1 (show PDX1 Antibodies)-Cre;LSL-KrasG12D model by exacerbating pancreatic intraepithelial neoplasias, promoting facial papillomas, and derepressing Wnt (show WNT2 Antibodies) signaling.

  3. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (show RACGAP1 Antibodies) methylation and activation and its downstream antiapoptotic signaling pathway.

  4. inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, tissue infiltration by myeloid cells, reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer.

Cow (Bovine) Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. ICMT inhibition induces endothelial cell apoptosis through GRP94 (show HSP90B1 Antibodies)

Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Antigen Profile

Protein Summary

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Gene names and symbols associated with ICMT

  • isoprenylcysteine carboxyl methyltransferase (icmt) antibody
  • isoprenylcysteine carboxyl methyltransferase (Bcen_5417) antibody
  • isoprenylcysteine carboxyl methyltransferase (Acid_0983) antibody
  • isoprenylcysteine carboxyl methyltransferase (Bcenmc03_4825) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Rpic_1767) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Mesil_1887) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Slip_1333) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Deba_2487) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Bresu_2161) antibody
  • isoprenylcysteine carboxyl methyltransferase (Mpet_0933) antibody
  • isoprenylcysteine carboxyl methyltransferase (Mpet_1639) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Saut_0066) antibody
  • isoprenylcysteine carboxyl methyltransferase (Intca_3523) antibody
  • isoprenylcysteine carboxyl methyltransferase (Deima_2891) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Despr_1203) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Deipr_0831) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_2650) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_3385) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_3501) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_4056) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_4939) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Theth_0229) antibody
  • isoprenylcysteine carboxyl methyltransferase (ICMT) antibody
  • isoprenylcysteine carboxyl methyltransferase (Icmt) antibody
  • 1700008E11Rik antibody
  • C80758 antibody
  • fcmt antibody
  • Gm13095 antibody
  • HSTE14 antibody
  • im:6895697 antibody
  • MST098 antibody
  • MSTP098 antibody
  • OTTMUSG00000010406 antibody
  • pcCMT antibody
  • PCMT antibody
  • PPMT antibody
  • STE14 antibody
  • zgc:110258 antibody

Protein level used designations for ICMT

protein-S-isoprenylcysteine O-methyltransferase , isoprenylcysteine carboxyl methyltransferase , Isoprenylcysteine carboxyl methyltransferase , prenylated protein carboxyl methyltransferase , prenylcysteine carboxyl methyltransferase , protein-S isoprenylcysteine O-methyltransferase , FCMT , PPMT , farnesyl cysteine carboxyl methyltransferase , pcCMT , prenylcysteine carboxyl methlytransferase

GENE ID SPECIES
550281 Danio rerio
4094605 Burkholderia cenocepacia AU 1054
4430863 Candidatus Solibacter usitatus Ellin6076
6127637 Burkholderia cenocepacia MC0-3
6287318 Ralstonia pickettii 12J
9251399 Meiothermus silvanus DSM 9946
9274122 Syntrophothermus lipocalidus DSM 12680
9494959 Desulfarculus baarsii DSM 2075
9504035 Brevundimonas subvibrioides ATCC 15264
9743393 Methanoplanus petrolearius DSM 11571
9744111 Methanoplanus petrolearius DSM 11571
9757577 Sulfurimonas autotrophica DSM 16294
10086362 Intrasporangium calvum DSM 43043
10152256 Deinococcus maricopensis DSM 21211
10173921 Desulfobulbus propionicus DSM 2032
10256310 Deinococcus proteolyticus MRP
10826487 Mesorhizobium opportunistum WSM2075
10827223 Mesorhizobium opportunistum WSM2075
10827339 Mesorhizobium opportunistum WSM2075
10827904 Mesorhizobium opportunistum WSM2075
10828798 Mesorhizobium opportunistum WSM2075
10884973 Thermotoga thermarum DSM 5069
23463 Homo sapiens
397717 Xenopus laevis
419373 Gallus gallus
489628 Canis lupus familiaris
57295 Mus musculus
170818 Rattus norvegicus
100514410 Sus scrofa
785548 Bos taurus
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