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LILRB2 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. Additionally we are shipping LILRB2 Antibodies (28) and LILRB2 Kits (2) and many more products for this protein.
Showing 10 out of 13 products:
Human LILRB2 Protein expressed in HEK-293 Cells - ABIN2181472
Borges, Hsu, Fanger, Kubin, Cosman: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 3 references for ABIN2181472
Human LILRB2 Protein expressed in Human Cells - ABIN2006069
Willcox, Thomas, Bjorkman: Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor. in Nature immunology 2003
Data indicate Ig-like transcript 4 (ILT4) as a cellular receptor for complement split products (CSPs) complement component 4d (C4d).
signaling involving ANGPTL2 (show ANGPTL2 Proteins) and LILRB2 is important for lung cancer development
Findings suggest that ILT4 drives NSCLC development in part on activation of ERK (show EPHB2 Proteins) signaling which in turn upregulates VEGF-C (show VEGFC Proteins).
Data show that the leukocyte antigen (show HLADRB4 Proteins) G HLA-G (show HLAG Proteins) alpha1-alpha3 structure, which constitutes the extracellular part of HLA-G2 and HLA-G6, binds the immunologic receptor LILRB2 but not LILRB1 (show LILRB1 Proteins).
Data show that immunoglobulin-like transcript 4 (ILT4) increases the expression of the co-inhibitory molecule B7-H3 (show CD276 Proteins) through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signalling.
involvement of ILT3 and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon (show IFNA Proteins) and vitamin D
A novel motif in the first and fourth Ig domains of LILRB2 was identified that is necessary for the receptor to be bound and activated by Angptl2 (show ANGPTL2 Proteins).
PIRB (show LILRB3 Proteins) and LILRB2 were expressed in mouse and human platelets, respectively.
ILT4 was found to be highly expressed in primary human ductal and lobular breast cancer cells, and its expression was significantly correlated with more IL-10 (show IL10 Proteins) expression.
we propose an impact of LILRB2 on HIV-1 disease outcomes through altered regulation of DCs by LILRB2-HLA engagement
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
, leukocyte immunoglobulin-like receptor subfamily B member 2-like
, CD85 antigen-like family member D
, Ig-like transcript 4
, leukocyte immunoglobulin-like receptor subfamily B member 2
, monocyte/macrophage immunoglobulin-like receptor 10