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Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 Proteins (LILRB2)

LILRB2 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. Additionally we are shipping LILRB2 Antibodies (29) and LILRB2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LILRB2 10288 Q8N423
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Top LILRB2 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$250.80
Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$269.50
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details
HOST_HEK-293 Cells Human Fc Tag,AVI tag,Biotin   200 μg Log in to see 41 to 71 Days
$1,714.29
Details

LILRB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , , ,

Top referenced LILRB2 Proteins

  1. Human LILRB2 Protein expressed in HEK-293 Cells - ABIN2181472 : Borges, Hsu, Fanger, Kubin, Cosman: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 3 references for ABIN2181472

  2. Human LILRB2 Protein expressed in Human Cells - ABIN2006069 : Willcox, Thomas, Bjorkman: Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor. in Nature immunology 2003 (PubMed)

More Proteins for Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2) Interaction Partners

Human Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2) interaction partners

  1. Data indicate Ig-like transcript 4 (ILT4) as a cellular receptor for complement split products (CSPs) complement component 4d (C4d).

  2. signaling involving ANGPTL2 (show ANGPTL2 Proteins) and LILRB2 is important for lung cancer development

  3. Findings suggest that ILT4 drives NSCLC development in part on activation of ERK (show EPHB2 Proteins) signaling which in turn upregulates VEGF-C (show VEGFC Proteins).

  4. Data show that the leukocyte antigen (show HLADRB4 Proteins) G HLA-G (show HLAG Proteins) alpha1-alpha3 structure, which constitutes the extracellular part of HLA-G2 and HLA-G6, binds the immunologic receptor LILRB2 but not LILRB1 (show LILRB1 Proteins).

  5. Data show that immunoglobulin-like transcript 4 (ILT4) increases the expression of the co-inhibitory molecule B7-H3 (show CD276 Proteins) through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signalling.

  6. involvement of ILT3 and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon (show IFNA Proteins) and vitamin D

  7. A novel motif in the first and fourth Ig domains of LILRB2 was identified that is necessary for the receptor to be bound and activated by Angptl2 (show ANGPTL2 Proteins).

  8. PIRB (show LILRB3 Proteins) and LILRB2 were expressed in mouse and human platelets, respectively.

  9. ILT4 was found to be highly expressed in primary human ductal and lobular breast cancer cells, and its expression was significantly correlated with more IL-10 (show IL10 Proteins) expression.

  10. we propose an impact of LILRB2 on HIV-1 disease outcomes through altered regulation of DCs by LILRB2-HLA engagement

LILRB2 Protein Profile

Protein Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with LILRB2

  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 (LILRB2)
  • CD85D protein
  • ILT-4 protein
  • ILT4 protein
  • LIR-2 protein
  • LIR2 protein
  • MIR-10 protein
  • MIR10 protein

Protein level used designations for LILRB2

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 , leukocyte immunoglobulin-like receptor subfamily B member 2-like , CD85 antigen-like family member D , Ig-like transcript 4 , leukocyte immunoglobulin-like receptor subfamily B member 2 , monocyte/macrophage immunoglobulin-like receptor 10

GENE ID SPECIES
100433990 Pongo abelii
10288 Homo sapiens
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