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anti-Like-Glycosyltransferase (LARGE) Antibodies

LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. Additionally we are shipping Like-Glycosyltransferase Proteins (5) and Like-Glycosyltransferase Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LARGE 9215 O95461
LARGE 16795 Q9Z1M7
LARGE 361368  
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Top anti-Like-Glycosyltransferase Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated EIA, WB AP20114PU-N LARGE antibody staining of Human Kidney lysate at 1 µg/ml (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-LARGE Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB LARGE antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$510.36
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Goat FITC ELISA   100 μL Log in to see 16 Days
$620.71
Details

LARGE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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, , , , ,
Mouse (Murine) ,
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Rat (Rattus) ,


Top referenced anti-Like-Glycosyltransferase Antibodies

  1. Cow (Bovine) Polyclonal LARGE Primary Antibody for EIA, WB - ABIN498027 : de Bernabé, Inamori, Yoshida-Moriguchi, Weydert, Harper, Willer, Henry, Campbell: Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE. in The Journal of biological chemistry 2009 (PubMed)

More Antibodies against Like-Glycosyltransferase Interaction Partners

Human Like-Glycosyltransferase (LARGE) interaction partners

  1. This study suggests LARGE as the first known modifier of plasma antithrombin (show SERPINC1 Antibodies).

  2. results reveal that the LARGE-glycan of dystroglycan serves as a tunable extra (show DAG1 Antibodies)cellular matrix protein scaffold, the extension of which is required for normal skeletal muscle function

  3. LARGE could act as a bifunctional glycosyltransferase (show GTDC2 Antibodies), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (show MMRN1 Antibodies) ligands

  4. the ligand-binding activity of alpha-dystroglycan is conferred primarily by LARGE modification at Thr (show TRH Antibodies)-317 and -319, within the highly conserved first 18 amino acids of the mucin (show SLC13A2 Antibodies)-like domain

  5. LARGE2 (show GYLTL1B Antibodies) was found to support the maturation of alpha-dystroglycan more effectively than LARGE.

  6. LARGE repression is responsible for the defects in dystroglycan (show DAG1 Antibodies)-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan (show DAG1 Antibodies) glycosylation as a factor in cancer progression

Mouse (Murine) Like-Glycosyltransferase (LARGE) interaction partners

  1. MBP1 (show ENO1 Antibodies) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (show ENO1 Antibodies) to reduce Ab pathology and improve behavioral performance.

  2. The overexpression of LARGE aggravates muscular dystrophy by suppressing the muscle regeneration and this adverse effect is mediated via reduced expression of IGF-1 (show IGF1 Antibodies).

  3. Endogenous glucuronyltransferase activity of LARGE or LARGE2 (show GYLTL1B Antibodies) required for functional modification of alpha-dystroglycan in cells and tissues.

  4. The overexpression of LARGE leads to a shortened lifespan and worsening of the FKRP (show FKRP Antibodies)-MD phenotype

  5. blocking Large during muscle regeneration results in synthesis of dystroglycan (show DAG1 Antibodies) with minimal LARGE-glycan repeats in association with less compact basement membrane, immature neuromuscular junctions, and dysfunctional muscle predisposed to dystrophy

  6. Muscular dystrophy defects are primarily due to the effects of LARGE and glycosylated dystroglycan (show DAG1 Antibodies) in stabilizing the endplate of the neuromuscular junction.

  7. LARGE could act as a bifunctional glycosyltransferase (show GTDC2 Antibodies), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (show MMRN1 Antibodies) ligands

  8. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase.

  9. a mechanism by which Large competes with galactosyltransferase to target GlcNAc terminals to induce the functional glycans on alpha-DG

  10. Previously unreported ocular defects in mice homozygous for a new allele of the Large gene, veils, and for Large(myd) mice.

Like-Glycosyltransferase (LARGE) Antigen Profile

Protein Summary

This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Gene names and symbols associated with LARGE

  • like-glycosyltransferase (LARGE) antibody
  • like-glycosyltransferase (large) antibody
  • glycosyltransferase-like 1B (GYLTL1B) antibody
  • like-glycosyltransferase (Large) antibody
  • BPFD36 antibody
  • DKFZp459G0120 antibody
  • enr antibody
  • fg antibody
  • froggy antibody
  • Gyltl1a antibody
  • gyltl1b antibody
  • gyltl1b-b antibody
  • LARGE antibody
  • Mbp-1 antibody
  • Mbp1 antibody
  • mdc1d antibody
  • MDDGA6 antibody
  • MDDGB6 antibody
  • mKIAA0609 antibody
  • myd antibody
  • NV15834 antibody

Protein level used designations for LARGE

glycosyltransferase-like protein LARGE1 , glycosyltransferase-like 1A , acetylglucosaminyltransferase-like 1A , acetylglucosaminyltransferase-like protein , like-glycosyltransferase , glycosyltransferase-like protein LARGE1-like , glycosyltransferase-like protein LARGE2 , like-acetylglucosaminyltransferase , myodystrophy , glycosyltransferase-like 1B , glycosyltransferase-like 1B-B , glycosyltransferase-like protein LARGE2-B

GENE ID SPECIES
418062 Gallus gallus
446213 Danio rerio
470192 Pan troglodytes
717403 Macaca mulatta
100068935 Equus caballus
100118066 Nasonia vitripennis
100174135 Pongo abelii
100346008 Oryctolagus cuniculus
100366528 Saccoglossus kowalevskii
100410756 Callithrix jacchus
100466251 Ailuropoda melanoleuca
423200 Gallus gallus
9215 Homo sapiens
16795 Mus musculus
361368 Rattus norvegicus
474521 Canis lupus familiaris
506466 Bos taurus
734944 Xenopus laevis
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