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NLRP12 encodes a member of the CATERPILLER family of cytoplasmic proteins. Additionally we are shipping NLRP12 Proteins (3) and many more products for this protein.
Showing 10 out of 109 products:
Human Monoclonal NLRP12 Primary Antibody for BCA - ABIN2665297
Allen: Non-Inflammasome Forming NLRs in Inflammation and Tumorigenesis. in Frontiers in immunology 2014
Show all 6 references for ABIN2665297
Human Polyclonal NLRP12 Primary Antibody for EIA, WB - ABIN453767
Ye, Lich, Moore, Duncan, Williams, Ting: ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. in Molecular and cellular biology 2008
Show all 3 references for ABIN453767
Human Polyclonal NLRP12 Primary Antibody for EIA, WB - ABIN783719
Tschopp, Martinon, Burns: NALPs: a novel protein family involved in inflammation. in Nature reviews. Molecular cell biology 2003
Show all 2 references for ABIN783719
Mouse (Murine) NLRP12 Primary Antibody for ELISA, WB - ABIN1686781
Jéru, Duquesnoy, Fernandes-Alnemri, Cochet, Yu, Lackmy-Port-Lis, Grimprel, Landman-Parker, Hentgen, Marlin, McElreavey, Sarkisian, Grateau, Alnemri, Amselem: Mutations in NALP12 cause hereditary periodic fever syndromes. in Proceedings of the National Academy of Sciences of the United States of America 2008
Human Polyclonal NLRP12 Primary Antibody for IHC (p), WB - ABIN657935
Cai, Batra, Del Piero, Jeyaseelan: NLRP12 modulates host defense through IL-17A-CXCL1 axis. in Mucosal immunology 2015
This process involved the upregulation of NLRP12.
NLRX1 (show NLRX1 Antibodies), NLRP12 and NLRC3 (show NLRC3 Antibodies) negatively modulate the host immune response following virus exposure. (Review)
Variants of NLRP12 were associated with common variable immunodeficiency.
NLRP12/NLRP3 (show NLRP3 Antibodies)-dependent activation of caspase-1 (show CASP1 Antibodies) is likely to be a key event in mediating systemic production of IL-1beta (show IL1B Antibodies) and hypersensitivity to secondary bacterial infection during malaria.
The genetics, expression and roles of NLRP12 in inflammatory signaling, host defense, and carcinogenes (show GUSB Antibodies)is are reviewed. Review.
This study suggested that NLRP12 mutations might account for a small fraction of common variable immunodeficiency patients with severe auto-inflammatory complications.
We will focus on NLRP6 (show NLRP6 Antibodies) and NLRP12.
Letter: NLRP12 mutations associated with familial cold autoinflammatory syndrome 2 in Italian patients.
Even with a variable range of associated manifestations, the extreme sensitivity to cold represents the main clinical hallmark in an individual carrying the p.D294E mutation of the NLRP12 gene.
The authors report the first in vitro confirmed non-homotypic interaction between NLRP12 pyrin (show MEFV Antibodies) domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1 (show FAF1 Antibodies)), which links the innate immune system to apoptotic signaling.
Nlrp12 deficiency caused increased neutrophil migration towards the chemokine (show CCL1 Antibodies) CXCL1 (show CXCL1 Antibodies) and the neutrophil parasite Leishmania major, revealing NLRP12 as a negative regulator of directed neutrophil migration under these conditions.
modulation of NLRP12 levels controls alternative NF-kappaB (show NFKB1 Antibodies) signaling in OC precursors, altering bone homeostasis and osteolytic responses
The absence of Nlrp12 results in an increased inflammatory response
NLRP12 is an intrinsic negative regulator of T-cell-mediated immunity via altered NF-kappaB (show NFKB1 Antibodies) regulation and IL-4 (show IL4 Antibodies) production as key mediators of NLRP12-associated disease.
The role of NLRP12 in NF-KB signaling, bacterial infections, colitis, colorectal tumorigenesis and gut (show GUSB Antibodies) homeostasis is studied in knockout mice. Review.
NLRP12-deficient mice are highly resistant to S. typhimurium infection, which highlights the signaling pathway defined by NLRP12-mediated dampening of host immune defenses that could be exploited by S. typhimurium to persist and survive in the host
NLRP12 does not significantly contribute to the in vivo host innate immune response to LPS (show TLR4 Antibodies) stimulation, Klebsiella pneumonia infection or Mycobacterium tuberculosis
NLRP12 negatively regulated ERK (show EPHB2 Antibodies) and AKT (show AKT1 Antibodies) signaling pathways in affected tumor tissues.
NLRP12 does not play a vital role in regulating Th2 driven airway inflammation using common model systems that are physiologically relevant to human disease.
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
NACHT, leucine rich repeat and PYD containing 12
, NLR family, pyrin domain containing 12
, PYRIN-containing APAF1-like protein 7
, NACHT, LRR and PYD domains-containing protein 12
, NLR family, pyrin domain containing 12, isoform 2
, monarch 1
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12
, regulated by nitric oxide
, NACHT, LRR and PYD containing protein 12