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displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. Additionally we are shipping NEDD8 Proteins (28) and NEDD8 Kits (4) and many more products for this protein.
Showing 10 out of 111 products:
Human Polyclonal NEDD8 Primary Antibody for IHC (p), WB - ABIN388037
Wu, Yamoah, Dolios, Gan-Erdene, Tan, Chen, Lee, Wei, Wilkinson, Wang, Pan: DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. in The Journal of biological chemistry 2003
Show all 5 references for ABIN388037
Human Polyclonal NEDD8 Primary Antibody for EIA, IHC (p) - ABIN356744
Bohnsack, Haas: Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. in The Journal of biological chemistry 2003
Show all 3 references for ABIN356744
Human Monoclonal NEDD8 Primary Antibody for EIA, FACS - ABIN1108404
Sowa, Bennett, Gygi, Harper: Defining the human deubiquitinating enzyme interaction landscape. in Cell 2009
Show all 2 references for ABIN1108404
Human Monoclonal NEDD8 Primary Antibody for ICC, FACS - ABIN969546
Ohki, Funatsu, Konishi, Chiba: The mechanism of poly-NEDD8 chain formation in vitro. in Biochemical and biophysical research communications 2009
the Cul1 (show CUL1 Antibodies)-based SCF (show KITLG Antibodies) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (show CCNE1 Antibodies) in vivo
Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (show SENP8 Antibodies) is crucial for animal viability.
CUL5 (show CUL5 Antibodies) neddylation may allosterically tune polyubiquitin (show UBB Antibodies) chain length and topology.
This study identifies MyD88 (show MYD88 Antibodies) as a novel substrate of NEDD8, and demonstrate that MyD88 (show MYD88 Antibodies) NEDDylation antagonizes its ubiquitination.
This study provides new knowledge of the CFTR (show CFTR Antibodies) biosynthetic pathway. It suggests that SYVN1 (show SYVN1 Antibodies) and FBXO2 (show FBXO2 Antibodies) represent two distinct multiprotein complexes that may degrade DeltaF508-CFTR (show CFTR Antibodies) in airway epithelia and identifies a new role for NEDD8 in regulating DeltaF508-CFTR (show CFTR Antibodies) ubiquitination.
Neddylation of Smurf1 (show SMURF1 Antibodies) activates its ubiquitin ligase activity and Smurf2 (show SMURF2 Antibodies) exerts Nedd8 ligase activity. This study provided new clues of Smurf2 (show SMURF2 Antibodies) activation regulation.
Nedd8(Q40E) cannot induce the same structural effect on Cul1 (show CUL1 Antibodies)-Rbx1 as wild-type Nedd8.
findings add novel evidence showing, for what we believe the first time, that NEDD8-mediated neddylation is required for normal human endometrial functions
In endothelial dysfunction, HDAC2 (show HDAC2 Antibodies) levels were reciprocally regulated by ectopic expression of NEDD8 and the de-NEDDylating enzyme SENP8 (show SENP8 Antibodies).
we report that MLN4924 (NEDD8 enzyme inhibitor ) specifically inhibited protein neddylation, inactivated cullin-RING E3 ligase (CRL (show IL31RA Antibodies)), the best-known neddylation substrate, and induced the accumulation CRL (show IL31RA Antibodies) substrates in lymphoma cells.
E1 (NAE1 (show NAE1 Antibodies) and UBA3 (show UBA3 Antibodies)) and E2 (UBC12 (show ube2m Antibodies)) enzymes, as well as global NEDD8 conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma
This work sheds new light on the roles of NEDD8 lysines on neddylation cascades and provides a dominant negative mutant for the study of neddylation and its biological functions.
Our findings provide mechanistic evidence of the effects of IAP (show ALPI Antibodies) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.
a role of Nedd8 in regulating caspase-1 (show CASP1 Antibodies) activation following inflammasome activation
Nedd8 and its associated E2 carrier protein (Ubc12 (show ube2m Antibodies)) and E3-SCF (show KITLG Antibodies) ligase play a key role in regulating the expression and activity of ENaC (show SCNN1A Antibodies) in alveolar pneumocytes.
a new regulatory mechanism of RCAN1 (show RCAN1 Antibodies) function
c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.
The NEDD8 pathway appears to play an important role in CD4 (show CD4 Antibodies)+ T-cell-mediated inflammatory responses
Nedd8 and AhR (show AHR Antibodies) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis
NEDD8 and ubiquitin function in a redundant manner in controlling receptor endocytic pathways.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
displays differential expression after induction by nerve growth factor
, neural precursor cell-expressed developmentally downregulated
, neural precursor cell expressed, developmentally down-regulated 8
, NEDD8 protein
, ubiquitin-like protein Nedd8
, neural precursor cell expressed, developmentally down-regulated gene 8
, neural precursor cell expressed developmentally down-regulated protein 8