Prolyl Endopeptidase Proteins (PREP)

The protein encoded by PREP is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Additionally we are shipping Prolyl Endopeptidase Antibodies (63) and Prolyl Endopeptidase Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PREP 5550 P48147
PREP 19072 Q9QUR6
PREP 83471 O70196
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Top Prolyl Endopeptidase Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Baculovirus infected Insect Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$4,070.00
Details
Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 2 to 3 Days
$413.21
Details

PREP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Prolyl Endopeptidase (PREP) Interaction Partners

Human Prolyl Endopeptidase (PREP) interaction partners

  1. These findings provide evidence for newly-discovered roles for PREP in mechanisms regulating cellular plasticity through NCAM (show NCAM1 Proteins) and PSA (show PLAG1 Proteins)-NCAM (show NCAM1 Proteins).

  2. Study shows that the expression of POP increases with hepatocyte steatosis suggesting an important role in hepatocytes steatosis and possibly NAFLD.

  3. It was found that human PREP behaves identically to the porcine homolog, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV (show DPP4 Proteins)).

  4. TLR4 (show TLR4 Proteins) activation releases prolyl endopeptidase containing exosomes from airway epithelial cells.

  5. This study found that circulating PREP activity was substantially reduced in all cirrhotic patients but those changes did not have evident correlation to hepatic encephalopathy.

  6. PEP was significantly and positively associated with delinquent, aggressive, externalizing and internalizing behavior subscales.

  7. PREP redox inactivation is due to oxidation of cysteine residues and consequent oligomerization through intermolecular disulfide bonds.

  8. Data indicate that SAXS analysis showed that presequence protease (hPreP (show PITRM1 Proteins)) open states and substrate binding dynamics.

  9. The determination of PEP (show PAEP Proteins) activity in the plasma may be a safe, minimally invasive and inexpensive way to define the aggressiveness of CRC (show CALR Proteins) in daily practice.

  10. first demonstration of colocalization of PREP and pathological proteins in the human brain, supporting the view that, at least in spatial terms, PREP could be associated with pathogenesis of neurodegenerative diseases

Pig (Porcine) Prolyl Endopeptidase (PREP) interaction partners

  1. Molecular modeling and docking based approaches were used to unravel questions like differences in ligand binding affinities in three POP species (porcine, human and A. thaliana).

Mouse (Murine) Prolyl Endopeptidase (PREP) interaction partners

  1. TLR4 (show TLR4 Proteins) activation releases prolyl endopeptidase containing exosomes from airway epithelial cells.

  2. the expression of prolyl endopeptidase could be necessary for a correct reproductive function

  3. As PREP inhibition also enhances autophagic clearance of aSyn, PREP inhibitors may reduce accumulation of aSyn inclusions via a dual mechanism and are thus a novel therapeutic candidate for synucleinopathies.

  4. lncPrep+96kb could play a role in the POP gene activation in the granulosa cell.

  5. PREP knockdown mice (Prep(gt/gt (show FABP6 Proteins))) exhibited glucose intolerance, decreased fasting insulin (show INS Proteins), increased fasting glucagon (show GCG Proteins) levels, and reduced glucose-induced insulin (show INS Proteins) secretion compared with wild-type controls.

  6. The study reveals a role for prolyl endopeptidase in mediating hippocampal plasticity and spatial memory formation.

  7. The POP promoter was sufficient for the appropriate localization in the placenta if it was not subject to position effect.

  8. the cytoplasmic and membrane-associated POP have distinct roles in different types of placental cells.

  9. alpha-MSH(1-13) is an in vivo substrate of PREP.

  10. Cigarette smoke-induced lung emphysema is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.

Prolyl Endopeptidase (PREP) Protein Profile

Protein Summary

The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides.

Gene names and symbols associated with Prolyl Endopeptidase Proteins (PREP)

  • prolyl endopeptidase (RB12337)
  • prolyl endopeptidase (AM1_4884)
  • Prolyl endopeptidase (ppce)
  • prolyl endopeptidase (PREP)
  • prolyl endopeptidase (Prep)
  • prolyl endopeptidase (prep)
  • AI047692 protein
  • AI450383 protein
  • D10Wsu136e protein
  • im:7140031 protein
  • PE protein
  • PEP protein
  • Pop protein
  • rPop protein
  • zgc:110670 protein

Protein level used designations for Prolyl Endopeptidase Proteins (PREP)

prolyl endopeptidase , Prolyl endopeptidase , dJ355L5.1 (prolyl endopeptidase) , post-proline cleaving enzyme , prolyl oligopeptidase , PE

GENE ID SPECIES
1791314 Rhodopirellula baltica SH 1
5683684 Acaryochloris marina MBIC11017
100305172 Oncorhynchus mykiss
5550 Homo sapiens
481945 Canis lupus familiaris
445540 Sus scrofa
286818 Bos taurus
19072 Mus musculus
83471 Rattus norvegicus
553791 Danio rerio
421785 Gallus gallus
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