Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). Additionally we are shipping PICK1 Kits (28) and PICK1 Proteins (14) and many more products for this protein.
Showing 10 out of 140 products:
Mammalian Monoclonal PICK1 Primary Antibody for ISt, IHC - ABIN1304917
Rocca, Hanley: PICK1 links AMPA receptor stimulation to Cdc42. in Neuroscience letters 2014
Show all 22 Pubmed References
Mouse (Murine) Polyclonal PICK1 Primary Antibody for ICC, IF - ABIN449250
Bassan, Liu, Madsen, Armsen, Zhou, Desilva, Chen, Paradise, Brasch, Staudinger, Gether, Irwin, Rosenberg: Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. in The European journal of neuroscience 2008
Show all 4 Pubmed References
Mouse (Murine) Polyclonal PICK1 Primary Antibody for ELISA, WB - ABIN188575
Xu, Sun, Gibson, Henkemeyer: A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses. in Nature neuroscience 2011
Show all 2 Pubmed References
Human Polyclonal PICK1 Primary Antibody for WB - ABIN391109
Xue, Zhang, Chen, Lin, Shi: PDZ protein mediated activity-dependent LTP/LTD developmental switch at rat retinocollicular synapses. in American journal of physiology. Cell physiology 2010
Mouse (Murine) Polyclonal PICK1 Primary Antibody for ICC, IF - ABIN189737
Sakamoto, Seiki: Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. in The Journal of biological chemistry 2009
PICK1 is a cargo-specific endocytic accessory protein required for efficient, activity-dependent AMPAR endocytosis.
Our results demonstrate that downregulation of PICK1 elicited by miR (show MLXIP Antibodies)-210-3p overexpression activates the TGF-b pathway, which further promotes bone metastasis in PCa (show FLVCR1 Antibodies), indicating that the miR (show MLXIP Antibodies)- 210-3p/PICK1/TGF-b signalling axis plays an important role in PCa (show FLVCR1 Antibodies) bone metastasis.
This study defines a novel mechanism whereby elevated [Ca(2 (show CA2 Antibodies)+)] induced by NMDA receptor activation modulates Ago2 (show EIF2C2 Antibodies) and miRNA activity via PICK1. Our work suggests a Ca(2 (show CA2 Antibodies)+)-dependent process to regulate miRNA activity in neurons in response to the induction of long-term depression.
We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention
PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2 (show ACTR2 Antibodies)/3 complex.
Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins.
Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ domains binding specificity.
PICK1 promotes Ago2 (show EIF2C2 Antibodies) localization at endosomal compartments in neuronal dendrites and inhibits Ago2 (show EIF2C2 Antibodies) function in translational repression following neuronal stimulation.
These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells.
C-terminal domain of ICA69 (show ICA1 Antibodies) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (show PKCa Antibodies) complex and cerebellar plasticity.
Ca(2 (show CA2 Antibodies)+) influx through ASIC1 (show ACCN2 Antibodies) mediates chronic hypoxia and ET-1 (show EDN1 Antibodies)-induced NFATc3 (show NFATC3 Antibodies) nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 (show NFATC3 Antibodies) nuclear import.
a dual role of PICK1 in regulating macrophage polarization
This study demonstrated that d-serine provent the behavioral deficits in adult Pick1 knockout mice.
PICK1 is an important regulator of P2Y6R (show P2RY6 Antibodies) expression and microglial phagocytosis.
knocking-out PICK1 gene casts the neuroprotection effect by reducing ASICs current and the calcium transients in OGD (show FGFR1 Antibodies)-Rep neuronal cells
ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
results indicate that PICK1 is a crucial regulator in glutathione homeostasis and may play important roles in oxidative stress.
In cultured neurons, PICK1 deletion increases surface AMPARs and blocks Abeta42-induced reduction in surface GluA2 (show GRIA2 Antibodies).
This study demonstrated that PICK1 functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size.
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
, protein interacting with C kinase 1
, protein kinase C-alpha-binding protein
, protein kinase C, alpha binding protein
, protein that interacts with C kinase 1
, protein interacting with PRKCA 1