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QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Additionally we are shipping QPRT Proteins (17) and QPRT Kits (6) and many more products for this protein.
Showing 10 out of 69 products:
Human Monoclonal QPRT Primary Antibody for IHC (p), ELISA - ABIN565099
Hinsch, Frank, Döring, Vorländer, Hansmann: QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study. in BMC cancer 2009
Human Polyclonal QPRT Primary Antibody for ELISA, WB - ABIN565098
Guillemin, Cullen, Lim, Smythe, Garner, Kapoor, Takikawa, Brew: Characterization of the kynurenine pathway in human neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
WT1 (show WT1 Antibodies) knock-down gave a corresponding decrease in QPRT gene and protein expression. Chromatin-immunoprecipitation revealed WT1 (show WT1 Antibodies) binding to a conserved site in the first intron of the QPRT gene.
The structural features, size distribution, heat aggregation and ITC studies of the full-length enzyme and the enzyme lacking helix alpha1 strongly suggest that human QPRT acts as a hexamer for cooperative reactant binding via three dimeric subunits and maintaining stability.
Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT.
QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules.
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
, nicotinate-nucleotide pyrophosphorylase (carboxylating)
, nicotinate-nucleotide pyrophosphorylase [carboxylating]
, nicotinate-nucleotide pyrophosphorylase
, quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))