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The protein encoded by SPP1 is involved in the attachment of osteoclasts to the mineralized bone matrix. Additionally we are shipping Osteopontin Kits (103) and Osteopontin Proteins (57) and many more products for this protein.
Showing 10 out of 427 products:
Human Monoclonal Osteopontin Primary Antibody for ICC, IF - ABIN259958
Kon, Yokosaki, Maeda, Segawa, Horikoshi, Tsukagoshi, Rashid, Morimoto, Inobe, Shijubo, Chambers, Uede: Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. in Journal of cellular biochemistry 2002
Show all 13 references for ABIN259958
Dog (Canine) Polyclonal Osteopontin Primary Antibody for EIA, IHC (p) - ABIN118005
Yamasaki, Nair, Bhattacharya, Yamamoto, Kurazono, Takeda: Cryptic appearance of a new clone of Vibrio cholerae serogroup 01 biotype El Tor in Calcutta, India. in Microbiology and immunology 1997
Show all 12 references for ABIN118005
Human Polyclonal Osteopontin Primary Antibody for EIA, IHC (p) - ABIN191686
Frosch, Barvencik, Lohmann, Viereck, Siggelkow, Breme, Dresing, Stürmer: Migration, matrix production and lamellar bone formation of human osteoblast-like cells in porous titanium implants. in Cells, tissues, organs 2002
Show all 3 references for ABIN191686
Human Polyclonal Osteopontin Primary Antibody for EIA, IF - ABIN953945
Weber, Lett, Haubein: Osteopontin is a marker for cancer aggressiveness and patient survival. in British journal of cancer 2010
Show all 3 references for ABIN953945
Mouse (Murine) Polyclonal Osteopontin Primary Antibody for IF (cc), IF (p) - ABIN723800
Zhang, Men, Fu, Shan, Ye, Wu, Tao, Liu, Jiang: Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones. in Cell and tissue research 2012
Show all 3 references for ABIN723800
Human Monoclonal Osteopontin Primary Antibody for ICC, IHC - ABIN1098149
Liersch, Gerss, Schliemann, Bayer, Schwöppe, Biermann, Appelmann, Kessler, Löwenberg, Büchner, Hiddemann, Müller-Tidow, Berdel, Mesters: Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients. in Blood 2012
Show all 2 references for ABIN1098149
Human Polyclonal Osteopontin Primary Antibody for ELISA, WB - ABIN185425
Kolb, Kleeff, Guweidhi, Esposito, Giese, Adwan, Giese, Büchler, Berger, Friess: Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions. in Cancer biology & therapy 2005
Dog (Canine) Polyclonal Osteopontin Primary Antibody for WB - ABIN2774903
Emani, Zhang, Guo, Guo, Kuo: RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer. in Surgery 2008
Human Polyclonal Osteopontin Primary Antibody for FACS, IHC (p) - ABIN390469
Agnihotri, Crawford, Haro, Matrisian, Havrda, Liaw: Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin). in The Journal of biological chemistry 2001
Cow (Bovine) Polyclonal Osteopontin Primary Antibody for IHC, WB - ABIN2774904
Iwata, Awaya, Graf, Kahl, Torok-Storb: Human marrow stromal cells activate monocytes to secrete osteopontin, which down-regulates Notch1 gene expression in CD34+ cells. in Blood 2004
The plasma OPN level >104.35 ng/mL was significantly associated with colorectal cancer. Findings suggest a significant role played by OPN (rs9138 and rs1126616) in colorectal carcinogenesis.
Results suggest that osteoblast-derived osteopontin (OPN) affects the interactions among oral squamous cell carcinoma (OSCC)-derived epithelial cells, osteoblasts, and osteoclasts.
Lower levels of both galectin-3 (show LGALS3 Antibodies) and osteopontin are associated with successful aging, representing potential biomarkers of this condition.
miR (show MLXIP Antibodies)-4262 suppresses OS metastases through OPN inhibition. Downregulation of miR (show MLXIP Antibodies)-4262 appears to directly contribute to the distal metastases of primary OS and subsequently poor prognosis.
OPN acts as a positive regulator in innate antiviral immunity through stabilization of TRAF3 (show TRAF3 Antibodies).
THBS2 (show THBS2 Antibodies), but not COL1A2 (show COL1A2 Antibodies) and SPP1, may serve as an indicator of gastric cancer prognosis.
OPN might serve as a prognostic biomarker, and the positive correlation between OPN and both VEGF (show VEGFA Antibodies) and MMP-9 (show MMP9 Antibodies) could implicate new insights in tumor angiogenesis.
Inhibition of p90 (show CANX Antibodies) ribosomal S6 kinase (show RPS6KB1 Antibodies) attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3beta (show GSK3b Antibodies) and osteopontin.
Elevated mRNA expression of SPP1 gene was revealed in breast tumors (2-7-fold) that correlated with SPP1 antigen immunoreactivity in autologous patients' sera.
our study demonstrates that levels of OPN were significantly different in patients with PDAC compared to patients with chronic pancreatitis.
These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.
The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.
Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.
results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene
Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.
A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608
The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (show CEBPB Antibodies) binding site and this binding site is negatively affected by the mutant G allele.
in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production
osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.
Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.
OPN induces oxidative stress via the involvement of mitochondria and NOX-4 (show NOX4 Antibodies). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK (show BIK Antibodies).
Endogenous osteopontin plays a critical role in the prevention of phosphate-induced nephrocalcinosis and vascular calcification in response to high phosphate load.
GATA4 (show GATA4 Antibodies) acts as a negative regulator of Bsp (show KLK6 Antibodies) expression in osteoblasts.
Genetic deletion of osteopontin in TRAMP (show DPT Antibodies) mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.
IFN-gamma (show IFNG Antibodies) regulates hypertensive vascular collagen remodeling induced by ANG II (show AGT Antibodies) and inhibits the differentiation of Th17 cells by suppressing OPN expression and regulating secretion of inflammatory cytokines.
results indicate that autocrine OPN plays a crucial role in HPC expansion, migration, and subsequent oncogenic transformation of HPCs, which may provide a new insight into hepatocarcinogenesis
OPN produced by hematogenous macrophages induces astrocyte process extension toward the infarct border zone, which may contribute to repair of the ischemic neurovascular unit following stroke
During the priming phase of liver regeneration, osteopontin enhances the recruitment of macrophages and neutrophils, and triggers hepatocyte proliferation through Kupffer cell-derived IL-6 (show IL6 Antibodies) release and the downstream activation of Stat3 (show STAT3 Antibodies).
OPN deficiency accelerated the spontaneous development of colitis in mice with disrupted gut (show GUSB Antibodies) microbiota and macrophage phagocytic activity.
mechanical stretch (MS) directly increased OPN protein expression and secretion in vascular smooth muscle cells.
This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.
Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.
Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.
Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.
OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs (show PTMS Antibodies)) compared to human Escherichia-coli-derived recombinant OPN without PTMs (show PTMS Antibodies).
topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (show CRISP1 Antibodies)
the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6
Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000
, SPP1/CALPHA1 fusion
, early T-lymphocyte activation 1
, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
, urinary stone protein
, bone sialoprotein 1
, 44 kDa bone phosphoprotein
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein
, Sialoprotein (osteopontin)
, bone sialoprotein I
, secreted phosphoprotein-1
, sphingosine-1-phosphatase 1