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Sialic Acid Binding Ig-Like Lectin 10 Proteins (SIGLEC10)

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Additionally we are shipping SIGLEC10 Antibodies (79) and SIGLEC10 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SIGLEC10 SIGLEC10 292844  
SIGLEC10 89790 Q96LC7
Mouse SIGLEC10 SIGLEC10 243958  
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Top SIGLEC10 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details

SIGLEC10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) interaction partners

  1. Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  2. Siglec-10-VAP-1 (show AOC3 Proteins) interaction seems to mediate lymphocyte adhesion to endothelium

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) interaction partners

  1. Aging Siglec-G-deficient and Siglec-G 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.

  2. Deficiency of SIGLEC-G was found to increase susceptibility to develop B-cell lymphoproliferative disorders.

  3. Siglec-G is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn (show LYN Proteins) and the proapoptotic factor BIM (show BCL2L11 Proteins) that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.

  4. Siglec-G-CD24 (show CD24 Proteins) axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD.

  5. Siglec-G sialic acid-dependent binding to the BCR (show BCR Proteins) is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2 (show CD22 Proteins)) on B cells.

  6. Data indicate that the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis in MRL/lpr (show FAS Proteins) mice.

  7. Siglec-G inhibits B cell activation (show BLNK Proteins) equally in both B1 & B2 subsets. It is expressed at a relatively constant level in numerous B cell subsets. It may maintain B cell tolerance toward self Ags (show GLA Proteins) in various B cell compartments.

  8. Data reveal a negative feedback loop of RIG-I (show DDX58 Proteins) signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses.

  9. The critical importance of pre-BCR (show BCR Proteins) and BCR (show BCR Proteins) receptor levels for the normal development of B-lymphocyte (show AKAP17A Proteins) subpopulations in the context of intact VDJ recombination and a diverse antibody repertoire.

  10. Siglec-G-deficient B1a lymphocytes survive longer in vitro and become the dominant population when injected in competition with wild-type B1a cells into Rag1 (show RAG1 Proteins)-deficient mice.

SIGLEC10 Protein Profile

Protein Summary

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).

Gene names and symbols associated with SIGLEC10

  • sialic acid binding Ig-like lectin 10 (SIGLEC10)
  • sialic acid binding Ig-like lectin 10 (siglec10)
  • sialic acid binding Ig-like lectin 10 (Siglec10)
  • sialic acid binding Ig-like lectin G (Siglecg)
  • 9830164H23 protein
  • A630096C01Rik protein
  • mSiglec-G protein
  • PRO940 protein
  • SIGLEC-10 protein
  • Siglec-G protein
  • Siglec10 protein
  • Siglecg protein
  • SLG2 protein

Protein level used designations for SIGLEC10

sialic acid binding Ig-like lectin 10 , sialic acid-binding Ig-like lectin 10-like , sialic acid binding Ig-like lectin G , sialic acid-binding Ig-like lectin 10 , sialic acid binding Ig-like lectin 10 Ig-like lectin 7 , siglec-like gene 2 , siglec-like protein 2

GENE ID SPECIES
468977 Pan troglodytes
504258 Bos taurus
100066644 Equus caballus
100158511 Xenopus (Silurana) tropicalis
100478360 Ailuropoda melanoleuca
100595513 Nomascus leucogenys
292844 Rattus norvegicus
89790 Homo sapiens
484343 Canis lupus familiaris
100513863 Sus scrofa
100340374 Oryctolagus cuniculus
100713177 Cavia porcellus
243958 Mus musculus
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