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SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Additionally we are shipping SIGLEC10 Antibodies (84) and SIGLEC10 Kits (13) and many more products for this protein.
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Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC (show FAM126A Proteins)).
Siglec-10-VAP-1 (show AOC3 Proteins) interaction seems to mediate lymphocyte adhesion to endothelium
The effect for Siglec-G deficiency in B cells results in higher B-1 cell numbers and a robust and preferential increase in oxidation-specific epitopes-specific IgM antibodies, which neutralize oxidized LDL-induced inflammation in vivo.
Aging Siglec-G-deficient and Siglec-G 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.
Deficiency of SIGLEC-G was found to increase susceptibility to develop B-cell lymphoproliferative disorders.
Siglec-G is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn (show LYN Proteins) and the proapoptotic factor BIM (show BCL2L11 Proteins) that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.
Siglec-G-CD24 (show CD24 Proteins) axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD.
Siglec-G sialic acid-dependent binding to the BCR (show BCR Proteins) is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2 (show CD22 Proteins)) on B cells.
Data indicate that the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis in MRL/lpr (show FAS Proteins) mice.
Siglec-G inhibits B cell activation (show BLNK Proteins) equally in both B1 & B2 subsets. It is expressed at a relatively constant level in numerous B cell subsets. It may maintain B cell tolerance toward self Ags (show GLA Proteins) in various B cell compartments.
Data reveal a negative feedback loop of RIG-I (show DDX58 Proteins) signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses.
The critical importance of pre-BCR (show BCR Proteins) and BCR (show BCR Proteins) receptor levels for the normal development of B-lymphocyte (show AKAP17A Proteins) subpopulations in the context of intact VDJ recombination and a diverse antibody repertoire.
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
sialic acid binding Ig-like lectin 10
, sialic acid-binding Ig-like lectin 10-like
, sialic acid binding Ig-like lectin G
, sialic acid-binding Ig-like lectin 10
, sialic acid binding Ig-like lectin 10 Ig-like lectin 7
, siglec-like gene 2
, siglec-like protein 2