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Sialic Acid Binding Ig-Like Lectin 7 Proteins (SIGLEC7)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping Sialic Acid Binding Ig-Like Lectin 7 Antibodies (204) and Sialic Acid Binding Ig-Like Lectin 7 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC7 27036 Q9Y286
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Top Sialic Acid Binding Ig-Like Lectin 7 Proteins at antibodies-online.com

Showing 6 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$739.20
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HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
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SIGLEC7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,

More Proteins for Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) interaction partners

  1. Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils.

  2. These results show that Siglec-7 binds HIV-1 via gp120 (show ITIH4 Proteins) and contributes to enhance the susceptibility to infection of CD4 (show CD4 Proteins) positive T cells and monocyte-derived macrophages.

  3. Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.

  4. Based on upregulated SIGLEC7 expression in blood monocytes during relapse, findings suggest a role for SIGLEC7 in acute disease activity in multiple sclerosis.

  5. Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition.

  6. Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 (show CD33 Proteins) surface receptors.

  7. Sialidase unmasking of siglec-7 on NK cells permits it to interact with GD3 on target cells and inhibit killing. This has inplications for tumor escape from NK cells.

  8. x-ray crystallographic analysis of the saccharide-binding domain of p75/AIRM1

  9. Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity

  10. Siglec-7 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2.

Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Protein Profile

Protein Summary

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene names and symbols associated with SIGLEC7

  • sialic acid binding Ig-like lectin 7 (SIGLEC7)
  • AIRM1 protein
  • CD328 protein
  • CDw328 protein
  • D-siglec protein
  • p75 protein
  • p75/AIRM1 protein
  • QA79 protein
  • SIGLEC-7 protein
  • SIGLEC7 protein
  • SIGLEC19P protein
  • SIGLECP2 protein

Protein level used designations for SIGLEC7

sialic acid binding Ig-like lectin 7 , AIRM-1 , QA79 membrane protein , adhesion inhibitory receptor molecule 1, siglec-7 , sialic acid binding immunoglobulin-like lectin 7 , sialic acid-binding Ig-like lectin 7

GENE ID SPECIES
468976 Pan troglodytes
100591540 Nomascus leucogenys
27036 Homo sapiens
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