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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Additionally we are shipping Sialic Acid Binding Ig-Like Lectin 7 Antibodies (211) and Sialic Acid Binding Ig-Like Lectin 7 Kits (4) and many more products for this protein.
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Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities.
Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils.
These results show that Siglec-7 binds HIV-1 via gp120 (show ITIH4 Proteins) and contributes to enhance the susceptibility to infection of CD4 (show CD4 Proteins) positive T cells and monocyte-derived macrophages.
Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.
Based on upregulated SIGLEC7 expression in blood monocytes during relapse, findings suggest a role for SIGLEC7 in acute disease activity in multiple sclerosis.
Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition.
Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 (show CD33 Proteins) surface receptors.
Sialidase unmasking of siglec-7 on NK cells permits it to interact with GD3 on target cells and inhibit killing. This has inplications for tumor escape from NK cells.
x-ray crystallographic analysis of the saccharide-binding domain of p75/AIRM1
Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
sialic acid binding Ig-like lectin 7
, QA79 membrane protein
, adhesion inhibitory receptor molecule 1, siglec-7
, sialic acid binding immunoglobulin-like lectin 7
, sialic acid-binding Ig-like lectin 7