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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Cation Transporter), Member 2 Proteins (6) and many more products for this protein.
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Human Polyclonal SLC22A2 Primary Antibody for ICC, IF - ABIN4354103
Li, Cui, Jiang, Guo, Pishdari, Hu, Feng, Billig, Shao: Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action. in American journal of translational research 2015
Show all 2 references for ABIN4354103
Cow (Bovine) Polyclonal SLC22A2 Primary Antibody for WB - ABIN2781589
Pelis, Suhre, Wright: Functional influence of N-glycosylation in OCT2-mediated tetraethylammonium transport. in American journal of physiology. Renal physiology 2006
Seventeen of the variants observed in the SLC22A2 gene of the Xhosa population were specific to/or occurred at a higher frequency in African populations or populations with a recent connection to the African continent.
We noted a statistically significant association between the nonsynonymous SNP rs316019(SLC22A2) and cisplatin-induced ototoxicity, in that the T allele occurred more frequently in patients who experienced no ototoxicity from cisplatin treatment.
the loss-of-function variant OCT2-T201M (rs145450955) contribute to changes in insulin (show INS Antibodies) resistance and beta cell activity in patients with T2D treated with metformin.
The 808G>T variant of SLC22A2 improves the metformin long-term glucose-lowering effect in Chinese type 2 diabetics.
functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2
Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 Antibodies)-3) in drug transportation.
The functional OCT2 Ser270Ala polymorphism is significantly associated with abstinence among treatment-seeking smokers.
Clopidogrel/clopidogrel carboxylate are weak inhibitors of OCT2.
The genetic polymorphisms in OCT2, AQP2 (show AQP2 Antibodies), AQP9 (show AQP7 Antibodies) and TMEM205 (show TMEM205 Antibodies) may contribute to chemotherapy response in lung cancer patients.
In chemotherapy for oesophageal cancers, cisplatin-induced nephrotoxicity seems to be unaffected by SLC22A2 polymorphism
OCTN2 (show SLC22A5 Antibodies) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha (show PPARA Antibodies).
Gene expression of the carnitine transporter OCTN2 (show SLC22A5 Antibodies) and carnitine transport are regulated by PPARbeta (show PPARD Antibodies)/delta in bovine cells.
Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes
Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels.
Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity.
Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 Antibodies), Slc22a2 and Slc22a3 (show OCT3 Antibodies) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Antibodies)+/-renal tumours.
findings identify OCT2 as an important postsynaptic determinant of aminergic tonus and mood-related behaviors.
Slc22a2 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.
OCT1 (show POU2F1 Antibodies) and OCT2 are important for N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (show PTPN2 Antibodies)) transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP (show PTPN2 Antibodies) and MPTP (show PTPN2 Antibodies)-induced dopaminergic toxicity in rodents.
a comparison of the transport properties of Oct2 and Oct1 (show POU2F1 Antibodies)
This study shows that Oct1 (show POU2F1 Antibodies) and Oct2 together are essential for renal secretion of (small) organic cations.
The carboxy-terminal activation domain of Oct-2 is required to mediate the unique and indispensable functions of the Oct-2 transcription factor in vivo.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.
, POU domain, class 2, transcription factor 2
, lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
, octamer-binding protein 2
, octamer-binding transcription factor 2
, organic cation transporter 2
, solute carrier family 22 member 2
, apical organic cation transporter
, solute carrier family 22, member 2