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SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Additionally we are shipping SLC7A11 Kits (10) and and many more products for this protein.
Showing 10 out of 94 products:
Human Polyclonal SLC7A11 Primary Antibody for FACS, ICC - ABIN152648
Liu, Blower, Pham, Fang, Dai, Wise, Green, Teitel, Ning, Ling, Lyn-Cook, Kadlubar, Sadée, Huang: Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. in Molecular pharmacology 2007
Show all 32 references for 152648
Human Polyclonal SLC7A11 Primary Antibody for ICC, IF - ABIN152647
Pampliega, Domercq, Soria, Villoslada, Rodríguez-Antigüedad, Matute: Increased expression of cystine/glutamate antiporter in multiple sclerosis. in Journal of neuroinflammation 2011
Show all 4 references for 152647
Human Polyclonal SLC7A11 Primary Antibody for ELISA, WB - ABIN252942
Zhang, Trachootham, Liu, Chen, Pelicano, Garcia-Prieto, Lu, Burger, Croce, Plunkett, Keating, Huang: Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. in Nature cell biology 2012
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Human Polyclonal SLC7A11 Primary Antibody for ELISA, WB - ABIN190899
Kaleeba, Berger: Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT. in Science (New York, N.Y.) 2006
Results suggest that expression of SLC7A11 in the context of glioma contributes to tumorigenesis, tumor progression, and resistance to standard chemotherapy.
High SLC7A11 expression is associated with glioma.
The most frequent SLC7A7 (show Slc7a7 Antibodies) mutation in Japanese LPI (show Slc7a7 Antibodies) patients is p.R410*, which is a founder effect mutation in northern Japan.
While the transsulfuration pathway plays a primary role in supplying Cys (show DNAJC5 Antibodies) to the redox system in the liver, xCT is induced in cases of emergencies, by compensating for Cys (show DNAJC5 Antibodies) supply systems.
Although LCN2 (show LCN2 Antibodies) increased intracellular iron concentrations, LCN2 (show LCN2 Antibodies)-induced GSH may catalyze and override oxidative stress via CD44 (show CD44 Antibodies) and xCT, and subsequently enhance the survival of clear cell carcinoma tumor cells in oxidative stress-rich environment.
Study demonstrated that the mRNA expression levels of the two system xc- subunits, SLC7A11 and SLC3A2 (show SLC3A2 Antibodies), in peripheral white blood cells are lowered in patients with schizophrenia than healthy individuals
the rate of cystine uptake was significantly faster than the rate of glutamate (show GRIN1 Antibodies) release in human glioma cells.
increased SLC7A11 expression predicted shorter malignant glioma patient survival.
We discovered that many genes involved in oxidative stress/antioxidant defense system, apoptosis/anti-apoptosis/cell death, and cellular response to unfolded proteins/topologically incorrect proteins are potentially regulated by xCT.
Data indicate that cystine-glutamate (show GRIN1 Antibodies) exchange transporter protein (show HNRNPU Antibodies) SLC7A11 mRNA is regulated by cellular stress and nonsense-mediated RNA decay (NMD).
HIF-1alpha (show HIF1A Antibodies) plays a role in cerebral ischaemia-reperfusion -induced glutamate (show GRIN1 Antibodies) excitotoxicity via the long-lasting activation of system xc(-) -dependent glutamate (show GRIN1 Antibodies) outflow
Results provided important insights into understanding the mechanism associated with xCT deficiency.
Protein expression of xCT was observed throughout the forebrain and amygdala.
Cerebellar astroglia isolated from Atm (show ATM Antibodies) mutant mice show decreased expression of the cystine/glutamate (show GRIN1 Antibodies) exchanger subunit xCT, glutathione reductase (show GSR Antibodies), and glutathione-S-transferase (show GSTa2 Antibodies)
IL-1beta (show IL1B Antibodies) increases the level of mRNA encoding xCT in primary cultures of astrocytes isolated from mouse cortex.
Study found that aglycemic neuronal cell death does not result from changes in astrocyte system xc- expression or activity or from impairment of glutamate (show GRIN1 Antibodies) removal
This study indicated that, under physiological conditions, nonvesicular glutamate (show GRIN1 Antibodies) release via system xc- mediates aspects of higher brain function related to anxiety and depression, but does not influence sensorimotor function or spatial vision
The study supports a novel role for the Slc7a11 in mediating T cell infiltration into the CNS as well as promoting myelin destruction after immune cell infiltration in experimental autoimmune encephalomyelitis.
glutamate (show GRIN1 Antibodies) released by the cystine/glutamate (show GRIN1 Antibodies) antiporter activated extrasynaptic, but not synaptic, NMDARs, and blockade of extrasynaptic NMDARs reduced ischemia-gated currents and cell damage after oxygen and glucose deprivation
In xCT knock-out mice, synapses showed increased spontaneous and evoked synaptic transmission.
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
, cystine/glutamate transporter
, solute carrier family 7, member 11
, Cystine/glutamate transporter
, cystine/glutamate transporter-like
, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
, amino acid transport system xc-
, calcium channel blocker resistance protein CCBR1
, solute carrier family 7 member 11
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
, cysteine/glutamate transporter
, sodium independent anionic amino acid transport system