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anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) Antibodies

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Proteins (12) and Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SDHB 6390 P21912
SDHB 67680 Q9CQA3
SDHB 298596 P21913
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Top anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Antibodies at antibodies-online.com

Showing 10 out of 123 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SDHB Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185447 (0.03µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated WB SDHB Antibody (C-term) (ABIN1881781) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the SDHB antibody detected the SDHB protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SDHB antibody, Western blotting All lanes: Anti SDHB  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: Rat Cardiac Muscle Tissue Lysate at 50ug Lane 3: Jurkat Whole Cell Lysate at 40ug Predicted bind size: 32KD Observed bind size: 32KD Anti-SDHB antibody, IHC(P) IHC(P): Rat Cardiac Muscle Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Sdhb AntibodyTitration: 1.0 µg/mL  Positive Control: Mouse Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: SDHB Antibody [NBP1-54154] - ICC staining of SDHB in HeLa cells with FITC (green). Nuclei were counterstained with Dapi (blue). Western Blot: SDHB Antibody [NBP1-54154] - Detection of SDHB in mouse kidney lysate. 0.1 mL Log in to see 7 to 9 Days
$381.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Simple Western: SDHB Antibody [NBP1-87069] - Simple Western lane view shows a specific band for SDHB in 0.2 mg/ml of RT-4 (left) and U-251MG sp (right) lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Simple Western: SDHB Antibody [NBP1-87069] - Electropherogram image(s) of corresponding Simple Western lane view. SDHB antibody was used at 1:20 dilution on RT-4 and U-251MG sp lysates(s). 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Goat Un-conjugated EIA, IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with SDHBat 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Antibody (0.03 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Muscle, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
$175.80
Details

SDHB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Antibodies

  1. Human Polyclonal SDHB Primary Antibody for ICC, IF - ABIN4352356 : van Nederveen, Gaal, Favier, Korpershoek, Oldenburg, de Bruyn, Sleddens, Derkx, Rivière, Dannenberg, Petri, Komminoth, Pacak, Hop, Pollard, Mannelli, Bayley, Perren, Niemann, Verhofstad, de Bruïne et al.: An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. ... in The Lancet. Oncology 2009 (PubMed)
    Show all 15 references for ABIN4352356

  2. Human Polyclonal SDHB Primary Antibody for WB - ABIN1881781 : Cerecer-Gil, Figuera, Llamas, Lara, Escamilla, Ramos, Estrada, Hussain, Gaal, Korpershoek, de Krijger, Dinjens, Devilee, Bayley: Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2010 (PubMed)
    Show all 4 references for ABIN1881781

  3. Human Polyclonal SDHB Primary Antibody for ICC, IF - ABIN4352351 : Morton, Beltram, Carter, Michailidou, Gorjanc, McFadden, Barrios-Llerena, Rodriguez-Cuenca, Gibbins, Aird, Moreno-Navarrete, Munger, Svenson, Gastaldello, Ramage, Naredo, Zeyda, Wang, Howie, Saari et al.: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. ... in Nature medicine 2016 (PubMed)
    Show all 2 references for ABIN4352351

  4. Human Polyclonal SDHB Primary Antibody for ELISA, WB - ABIN185447 : Selak, Armour, MacKenzie, Boulahbel, Watson, Mansfield, Pan, Simon, Thompson, Gottlieb: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. in Cancer cell 2005 (PubMed)
    Show all 2 references for ABIN185447

  5. Cow (Bovine) Polyclonal SDHB Primary Antibody for WB - ABIN2783181 : Cascón, Landa, López-Jiménez, Díez-Hernández, Buchta, Montero-Conde, Leskelä, Leandro-García, Letón, Rodríguez-Antona, Eng, Neumann, Robledo: Molecular characterisation of a common SDHB deletion in paraganglioma patients. in Journal of medical genetics 2008 (PubMed)
    Show all 2 references for ABIN2783181

More Antibodies against Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Interaction Partners

Fruit Fly (Drosophila melanogaster) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. sdhB mutant is hypersensitive to oxygen and displays hallmarks of a progeroid syndrome

Human Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. For classification, tumors were characterized by SDHA (show SDHA Antibodies), B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline

  2. Mutations in some enzymes of the TCA cycle: Isocitrate dehydrogenase (IDH (show IDH1 Antibodies)), succinate dehydrogenase (SDH (show SDHA Antibodies)) and fumarate hydratase (FH (show FH Antibodies)) are associated with the accumulation of metabolites that are able to influence many aspects of cancer development and progression and for this reason are termed onco-metabolites.

  3. Heterozygous germline deletions of up to 104 kb in size were identified in SDHB, SDHC (show SDHC Antibodies), SDHD (show SDHD Antibodies) and flanking genes in 20 paraganglioma-pheochromocytoma patients. The exact breakpoint could be determined in 16 paraganglioma-pheochromocytoma patients of which 15 were novel deletions

  4. compound germline heterozygosity of mouse Sdhb/Sdhc/Sdhd null alleles blunts chronic hypoxia-induced increases in hemoglobin levels, an adaptive response mainly regulated by HIF-2a

  5. Of which 4 SDHB and 2 TMEM127 (show TMEM127 Antibodies) mutations were novel.

  6. Data suggest that succinate dehydrogenases SDHA (show SDHA Antibodies) and SDHB immunohistochemistry should be interpreted with caution, due to possible false-positive or false-negative results, and ideally in the setting of quality assurance provided by molecular testing.

  7. Our study, suggests that SDH (show SARDH Antibodies) loss was suggestive of metastatic behavior in addition to younger age at diagnosis, larger tumor size, and higher Ki67 (show MKI67 Antibodies) proliferation rate and catecholamine type in paragangliomas of the urinary bladder

  8. Our results demonstrated that down-regulation of SDHB and up-regulation of PDK1 (show PDK1 Antibodies) may be novel biomarkers for predicting advanced tumor progression and unfavorable prognosis in recurrent nasopharyngeal carcinoma patients

  9. According to international guidelines, SDHB, SDHC (show SDHC Antibodies), and SDHD (show SDHD Antibodies) genetic testing were performed in this patient, but not SDHA (show SDHA Antibodies), which would have been prescribed only after surgery, in case of SDHA (show SDHA Antibodies) negative immunohistochemistry

  10. that SDHAF1 (show SDHAF1 Antibodies) contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subunit of CII, SDHB.

Pig (Porcine) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. tissue expression analysis indicated that that swine SDHB, SNRPA (show SNRPA Antibodies) and CRYBB1 (show CRYBB1 Antibodies) gene were differentially expressed in tissues including fat, lung, muscle, small intestine, kidney, large intestine, spleen and liver

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. Data show that lack of succinate dehydrogenase (SDH (show SDHA Antibodies)) activity commits cells to consume extracellular pyruvate.

  2. Using Sdhb(+/-) mice, we provide evidence that pituitary hyperplasia in SDHx-deficient cells may be the initial abnormality in the cascade of events leading to pituitary adenoma formation.

  3. Tumor-derived FH and SDH (show SDS Antibodies) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Antibodies).

  4. Data show that two subunits of complex II (succinate dehydrogenase (show SDHD Antibodies), or SDH (show SDS Antibodies)), SDHA (show SDHA Antibodies) and SDHB, interacted specifically with SIRT3 (show SIRT3 Antibodies).

Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) Antigen Profile

Protein Summary

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Gene names and symbols associated with SDHB

  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB) antibody
  • succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3 (SDH2-3) antibody
  • Succinate dehydrogenase B (SdhB) antibody
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (sdhb) antibody
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb) antibody
  • 0710008N11Rik antibody
  • CG3283 antibody
  • CWS2 antibody
  • Dmel\\CG3283 antibody
  • fj46d06 antibody
  • IP antibody
  • PGL4 antibody
  • SDH antibody
  • SDH-Ip antibody
  • SDH1 antibody
  • SDH2 antibody
  • sdhB antibody
  • SDHIP antibody
  • succinate dehydrogenase 2-3 antibody
  • wu:fj46d06 antibody

Protein level used designations for SDHB

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial , succinate dehydrogenase complex subunit B , CG3283-PA , COMPLEX II: iron-sulfur subunit , SdhB-PA , iron-sulfur protein subunit of succinate dehydrogenase , succinate dehydrogenase , succinate dehydrogenase B , succinate dehydrogenase Iron-sulfur , succinate dehydrogenase Iron-sulfur protein , succinate dehydrogenase iron protein , succinate dehydrogenase subunit b , iron-sulfur subunit of complex II , Iron-sulfur subunit of complex II , IP , ip

GENE ID SPECIES
100050091 Equus caballus
770063 Arabidopsis thaliana
35590 Drosophila melanogaster
100144957 Xenopus (Silurana) tropicalis
6390 Homo sapiens
478217 Canis lupus familiaris
414412 Sus scrofa
286840 Bos taurus
100328585 Oryctolagus cuniculus
67680 Mus musculus
298596 Rattus norvegicus
562149 Danio rerio
379939 Xenopus laevis
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