anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Antibodies

TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. Additionally we are shipping TIGIT Proteins (47) and TIGIT Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TIGIT 201633 Q495A1
TIGIT 100043314  
TIGIT 363784  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-TIGIT Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Host: Rabbit Target Name: TIGIT Sample Tissue: Human Fetal Kidney Antibody Dilution: 1.0ug/ml WB Suggested Anti-TIGIT Antibody Titration: 1.0 ug/ml Positive Control: HepG2 Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Allophycocyanin FACS Detection of TIGIT in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) gated on CD3- cells were stained with Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody. Detection of TIGIT in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) gated on CD3- cells were stained with Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$372.75
Details
Mouse Sheep Allophycocyanin FACS Detection of TIGIT in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes treated with 50 ng/mL PMA and 200 ng/mL Calcium Ionomycin overnight were stained with Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody. Detection of TIGIT in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes treated with 50 ng/mL PMA and 200 ng/mL Calcium Ionomycin overnight were stained with Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$367.50
Details
Mouse Mouse PE ELISA (Capture) 100 μg Log in to see 10 to 12 Days
$309.81
Details
Mouse Mouse APC ELISA (Detection), ELISPOT (Detection) 100 μg Log in to see 10 to 12 Days
$309.81
Details
Human Mouse PerCP FACS Detection of TIGIT in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody. Detection of TIGIT in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$162.75
Details
Human Mouse PE FACS Detection of TIGIT in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) gated on CD3- cells were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody. Detection of TIGIT in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) gated on CD3- cells were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$320.25
Details
Mouse Mouse Un-conjugated ICFC 500 μg Log in to see 10 to 12 Days
$320.68
Details
Human Mouse Alexa Fluor 700 FACS Detection of TIGIT in Human PBMC lymphocytes by Flow Cytometry. Human peripheral blood mononuclear cell (PBMC) lymphocytes were stained with Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody. Detection of TIGIT in Human PBMC lymphocytes by Flow Cytometry. Human peripheral blood mononuclear cell (PBMC) lymphocytes were stained with Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$341.25
Details
Human Mouse Un-conjugated BR, FACS Detection of TIGIT in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human TIGIT Monoclonal Antibody. Detection of TIGIT in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human TIGIT Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$285.60
Details

TIGIT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
,
,
, , , , , , , , , , ,
Mouse (Murine) , , , ,
, ,
,
, , , , ,
Rat (Rattus)


Top referenced anti-TIGIT Antibodies

  1. Mouse (Murine) Monoclonal TIGIT Primary Antibody for ICFC - ABIN2665414 : Stanietsky, Simic, Arapovic, Toporik, Levy, Novik, Levine, Beiman, Dassa, Achdout, Stern-Ginossar, Tsukerman, Jonjic, Mandelboim: The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 3 references for 2665414

  2. Mouse (Murine) Monoclonal TIGIT Primary Antibody for ELISA (Capture) - ABIN2662886 : Levin, Taft, Brandt, Bucher, Howard, Chadwick, Johnston, Hammond, Bontadelli, Ardourel, Hebb, Wolf, Bukowski, Rixon, Kuijper, Ostrander, West, Bilsborough, Fox, Gao, Xu, Ramsdell, Blazar, Lewis: Vstm3 is a member of the CD28 family and an important modulator of T-cell function. in European journal of immunology 2011 (PubMed)
    Show all 3 references for 2662886

  3. Mouse (Murine) Monoclonal TIGIT Primary Antibody for ELISA (Detection), ELISPOT (Detection) - ABIN2658413 : Yu, Harden, Gonzalez, Francesco, Chiang, Irving, Tom, Ivelja, Refino, Clark, Eaton, Grogan: The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. in Nature immunology 2008 (PubMed)
    Show all 3 references for 2658413

  4. Mouse (Murine) Polyclonal TIGIT Primary Antibody for FACS - ABIN4896939 : Stanietsky, Rovis, Glasner, Seidel, Tsukerman, Yamin, Enk, Jonjic, Mandelboim: Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR. in European journal of immunology 2013 (PubMed)
    Show all 2 references for 4896939

  5. Human Monoclonal TIGIT Primary Antibody for FACS - ABIN4895251 : Yasuma, Yasunaga, Takemoto, Sugata, Mitobe, Takenouchi, Nakagawa, Suzuki, Matsuoka: HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). in PLoS pathogens 2016 (PubMed)

More Antibodies against TIGIT Interaction Partners

Human T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) interaction partners

  1. Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 (show PVRL2 Antibodies) by TIGIT.

  2. TIGIT is a powerful negative regulator of CD4 (show CD4 Antibodies)(+) T cells in systemic lupus erythematosus.

  3. TIGIT signaling in NK cells after MDSC coculture led to a decrease in the phosphorylation of ZAP70 (show ZAP70 Antibodies)/Syk (show SYK Antibodies) and ERK1/2 (show MAPK1/3 Antibodies).

  4. energetic basis for the TIGIT/nectin-2 (show PVRL2 Antibodies) interaction and revealed that an "aromatic key" of nectin-2 (show PVRL2 Antibodies) is critical for this interaction, whereas variations in the lock were tolerated.

  5. TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization.

  6. implying that TIGIT exerts immunosuppressive effects by competing with DNAM-1 (show CD226 Antibodies) for the same ligand, CD155 (show PVR Antibodies)

  7. These findings identify TIGIT as a novel marker of dysfunctional HIV-specific T cells

  8. This study shows that HBZ (show HBZ Antibodies)-induced TIGIT plays a pivotal role in attenuating host immune responses and shaping a microenvironment favorable to human T-cell leukemia virus type 1.

  9. a novel mechanism that links TIGIT expression with NK-cell functional heterogeneity, and this mechanism might partially explain why individuals have different susceptibilities to infection, autoimmune disease, and cancer.

  10. Human regulatory T cells expressing the receptors TIGIT and CD226 (show CD226 Antibodies) display widely divergent phenotypes in regard to expansion and activation.

Mouse (Murine) T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) interaction partners

  1. TIGIT is a powerful negative regulator of CD4 (show CD4 Antibodies)(+) T cells in systemic lupus erythematosus.

  2. study provides evidence that TIGIT expression by Th cells and its interaction with CD155 (show PVR Antibodies) enhances Th2 responses, and blockade of TIGIT is therapeutic for experimental allergic airway inflammation

  3. TIGIT negatively regulates inflammation by altering macrophage phenotype.

  4. TIGIT signaling in Tregs directs their phenotype. It suppresses antitumor immunity via Tregs and not CD8 (show CD8A Antibodies)+ T cells. TIGIT+ Tregs upregulated TIM-3 (show HAVCR2 Antibodies) expression in tumor tissue. TIM-3 (show HAVCR2 Antibodies) and TIGIT synergized to suppress antitumor immune responses.

  5. TIGIT is a safeguard molecule to improve liver regeneration through negatively regulating NK-hepatocyte crosstalk.

  6. Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 (show CD226 Antibodies) function when disrupting its homodimerization.

  7. TIGIT/PVR (show PVRL2 Antibodies) ligation signaling mediates suppression of IFN-gamma (show IFNG Antibodies) production via the NF-kappaB (show NFKB1 Antibodies) pathway.

  8. expressed on a Treg cell subset that selectively suppresses Th1 (show HAND1 Antibodies) and Th17 cells but not Th2 cells

  9. found that TIGIT was up-regulated selectively on NK cells and protected against liver injury in an acute adenovirus infection model in both an NK cell- and Kupffer cell-dependent manner

  10. findings show that TIGIT is expressed by NK cells, that it interacts specifically with PVR (show PVRL2 Antibodies) and possibly with an additional unknown ligand found on PBMCs and that these interactions lead to the inhibition of NK-cell activities

TIGIT Antigen Profile

Protein Summary

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity\; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.

Gene names and symbols associated with TIGIT

  • T cell immunoreceptor with Ig and ITIM domains (TIGIT) antibody
  • T cell immunoreceptor with Ig and ITIM domains (Tigit) antibody
  • ENSMUSG00000071552 antibody
  • RGD1563191 antibody
  • VSIG9 antibody
  • Vstm3 antibody
  • WUCAM antibody

Protein level used designations for TIGIT

T-cell immunoreceptor with Ig and ITIM domains , V-set and immunoglobulin domain containing 9 , V-set and immunoglobulin domain-containing protein 9 , V-set and transmembrane domain containing 3 , V-set and transmembrane domain-containing protein 3 , Washington University cell adhesion molecule

GENE ID SPECIES
201633 Homo sapiens
100043314 Mus musculus
363784 Rattus norvegicus
Selected quality suppliers for anti-TIGIT (TIGIT) Antibodies
Did you look for something else?