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TIMP Metallopeptidase Inhibitor 3 Proteins (TIMP3)

TIMP3 belongs to the TIMP gene family. Additionally we are shipping TIMP3 Antibodies (188) and TIMP3 Kits (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TIMP3 7078 P35625
TIMP3 25358  
TIMP3 21859 P39876
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Top TIMP3 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Cow His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$911.90
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,333.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,449.33
Details
Yeast Horse His tag   1 mg Log in to see 56 to 66 Days
$2,449.33
Details

TIMP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Rat (Rattus) ,

Mouse (Murine)

More Proteins for TIMP Metallopeptidase Inhibitor 3 (TIMP3) Interaction Partners

Human TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. expression of TIMP3 is low in pituitary adenomas including ACTH (show POMC Proteins)-secreting pituitary adenomas and negatively associated with tumor aggressiveness.

  2. Genotypes of rs135025 and rs80272 in TIMP3 contribute to the development of preeclampsia in Han Chinese women.

  3. TIMP3 was validated as a direct target of miRNA-21 by dual-luciferase reporter assay. Silencing with small interfering RNA against TIMP3 promoted angiogenesis and increased MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins) expression at the protein level.

  4. TIMP3 is a dominant negative regulator of angiogenesis in cutaneous melanoma and gene silencing by promoter methylation is associated with poor outcome

  5. Taken together, our results suggest that the imbalance between aggrecanase (show ADAMTS4 Proteins) and TIMP-3 may play an important role in the pathogenesis of IDD (show COL9A3 Proteins) and therefore be a potential therapeutic target for treating IDD (show COL9A3 Proteins).

  6. Gene-gene interactions between Smad3 (show SMAD3 Proteins) rs6494629T/C and TIMP3 rs715572G/A polymorphisms may play more important protective roles in knee OA.

  7. Results suggest that gene-environment interactions between the TIMP3 rs9862 polymorphisms and betel quid may alter oral cancer susceptibility and tumor growth in Taiwanese men.

  8. following acute ACL (show ACLY Proteins) injury, an upregulation of TIMP-3, the primary aggrecanase (show ADAMTS4 Proteins) inhibitor, is elicited in response to increased aggrecan (show ACAN Proteins) degradation, which may inhibit further cleavage

  9. TIMP3) promotes endothelial apoptosis via a caspase (show CASP3 Proteins)-independent mechanism.

  10. This data shows that increased expression of miR (show MLXIP Proteins)-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition.

Rabbit TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 (show MMP1 Proteins) and decreased TIMP-3 secretion.

  2. TIMP-3 is downregulated in a distinct subpopulation of atherosclerotic foam cells which have increased MMP-14 (show MMP14 Proteins).

Cow (Bovine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. Reactive oxygen species mediate TGF-beta1 (show TGFB1 Proteins)-induced TIMP-3 gene expression

  2. TIMP3 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

  3. TIMP3 mRNA expression level was upregulated by multidirectional articular motion.

Xenopus laevis TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. only the N-terminal, but not the C-terminal domain of TIMP-3, results in developmental defects.

  2. metamorphic tail and intestine RNA levels of TIMP-2 (show TIMP2 Proteins), MT1-MMP (show MMP14 Proteins) and Gel-A, but not MT3-MMP (show MMP24 Proteins) or TIMP-3, are elevated during periods of cell death and proliferation

Mouse (Murine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. data strongly suggest that TIMP3 has direct neuroprotective effects that can mitigate the deleterious effects associated with TBI (show TBPL1 Proteins), an area with few if any therapeutic options.

  2. Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions.

  3. 4-Hydroxyisoleucine improved insulin (show INS Proteins) resistant-like state in 3T3-L1 adipocytes by targeting TACE (show ADAM17 Proteins)/TIMP3 and the insulin (show INS Proteins) signaling pathway.

  4. In a mouse model of prostate cancer, increased tumor growth, proliferation index, increased microvascular density, and invasion was observed in Pten(-/-), Timp3(-/-) prostate tumors compared to Pten(-/-), Timp3(+/+) tumors.

  5. Timp3 status determines p53 (show TP53 Proteins), p38 (show CRK Proteins) and Notch (show NOTCH1 Proteins) coactivation to instruct hepatic cell fate and transformation.

  6. TIMP2 (show TIMP2 Proteins) and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  7. Expansion of stem cells counteracts age-related mammary regression in compound Timp1 (show TIMP1 Proteins)/Timp3-deficient mice.

  8. lack of TIMP3 increases inflammation and polarizes macrophages towards a more inflammatory phenotype resulting in increased atherosclerosis.

  9. TIMP-3 KO mice exhibit enhanced metabolism, as reflected by a higher body temperature than WT mice, possibly due to increased mitochondrial activity.

  10. TIMP3 protects kidney from damage

Pig (Porcine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. These results suggest the crucial role of TIMP-3 in successful implantation and embryo survival and indicate the endometrial stromal decidualization-like in pigs.

TIMP3 Protein Profile

Protein Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.

Gene names and symbols associated with TIMP3

  • metalloproteinase inhibitor 3 (CpipJ_CPIJ003282)
  • TIMP metallopeptidase inhibitor 3 (TIMP3)
  • Metalloproteinase inhibitor 3 (timp3)
  • TIMP metallopeptidase inhibitor 3 (Timp3)
  • TIMP metallopeptidase inhibitor 3 (timp3)
  • tissue inhibitor of metalloproteinase 3 (Timp3)
  • tissue inhibitor of metalloproteinase-3 (TIMP-3)
  • HSMRK222 protein
  • IMP-3 protein
  • K222 protein
  • K222TA2 protein
  • SFD protein
  • Timp-3 protein
  • timp3 protein
  • timp3-A protein

Protein level used designations for TIMP3

metalloproteinase inhibitor 3 , TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) , tissue inhibitor metalloproteinase-3 , TIMP metallopeptidase inhibitor 3 , Metalloproteinase inhibitor 3 , MIG-5 protein , TIMP-3 , protein MIG-5 , tissue inhibitor of metalloproteinases 3 , tissue inhibitor of metalloproteinase-3 , tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) , tissue inhibitor of metalloproteinase 3 , 21 kDa protein of extracellular matrix , tissue inhibitor of metalloproteinases-3

GENE ID SPECIES
6034728 Culex quinquefasciatus
481289 Canis lupus familiaris
100135460 Papio anubis
100196821 Salmo salar
7078 Homo sapiens
100008690 Oryctolagus cuniculus
25358 Rattus norvegicus
282094 Bos taurus
100033947 Equus caballus
396483 Gallus gallus
373596 Xenopus laevis
574381 Macaca mulatta
100217407 Ovis aries
21859 Mus musculus
396775 Sus scrofa
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