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Talin 1 Proteins (TLN1)

TLN1 encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. Additionally we are shipping Talin 1 Antibodies (139) and Talin 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TLN1 7094 Q9Y490
Mouse TLN1 TLN1 21894 P26039
Rat TLN1 TLN1 313494  
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Top Talin 1 Proteins at

Showing 5 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag Talin 1 (TLN1) (AA 92-399), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days

TLN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Top referenced Talin 1 Proteins

  1. Human TLN1 Protein expressed in Escherichia coli (E. coli) - ABIN1047720 : Ben-Yosef, Francomano: Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern. in Genomics 2000 (PubMed)
    Show all 2 references for ABIN1047720

More Proteins for Talin 1 (TLN1) Interaction Partners

Horse (Equine) Talin 1 (TLN1) interaction partners

  1. CD90 (Thy1 (show THY1 Proteins)) is a novel interactor of talin 1 in effector cells of autoimmune equine uveitis.

Human Talin 1 (TLN1) interaction partners

  1. These findings suggested that Talin-1 protein was significantly upregulated in PCa (show FLVCR1 Proteins) tissues compared with that of BPH (show GLI3 Proteins) tissue and Talin-1 expression was an independent predictor for lymph node metastasis and biochemical recurrence of PCa (show FLVCR1 Proteins).

  2. Serum talin-1 had 97.7% sensitivity.

  3. Both TLN-1 and TLN-2 levels correlate with tumorigenicity in human HCC (show FAM126A Proteins), indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma .

  4. TLN1 significantly increases in refractory glioblastoma multiforme

  5. Applying correlative imaging to link live cell and fixed immunofluorescence data on a single cell basis, we related per cell talin-1 levels to per cell measures quantitatively defining an array of cellular properties.

  6. Disruption of the RIAM/lamellipodin-integrin-talin complex markedly impairs cell migration.

  7. Our data demonstrate that high expression of Talin-1 is associated with significantly poorer OS and poorer DMFS in NPC (show NPC1 Proteins) and depletion of Talin-1 expression inhibited NPC (show NPC1 Proteins) cell migration and invasion. Talin-1 may serve as novel prognostic biomarker in NPC (show NPC1 Proteins).

  8. The activation of vinculin (show VCL Proteins) by stretched talin induces a positive feedback that reinforces the actin-talin-vinculin (show VCL Proteins) association.

  9. Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb/GPIIIa (show ITGB3 Proteins) complex transmembrane/C-terminal domains and talin-1 in cell membrane environment during platelet activation.

  10. Data suggest that anionic lipids (such as phosphatidylinositol phosphates) play crucial role in localization of peripheral membrane proteins (such as TLN1, auxilin-1, and PTEN [phosphatase and tensin homolog]). [review-like article]

Mouse (Murine) Talin 1 (TLN1) interaction partners

  1. These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin (show FN1 Proteins) binding and adhesion.

  2. Binding of vinculin (show VCL Proteins) to the R1-R3 region of the talin rod is important for focal adhesion stability.

  3. Data indicate that talin mechanics are isoform specific so that expression of either talin-1 or talin-2 modulates extracellular rigidity sensing.

  4. Conformational activation of talin by PREL-1 (show APBB1IP Proteins) triggers integrin-mediated cell adhesion.

  5. Direct methylation of talin, a key regulatory molecule in cell migration, by Ezh2 disrupted the binding of talin to F-actin and thereby promoted the turnover of adhesion structures.

  6. reduction of talin-beta3 integrin (show ITGB3 Proteins) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding

  7. As talin engages F-actin, force exerted on the R2R3 helical bundles disrupts RIAM (show APBB1IP Proteins) binding and exposes the vinculin (show VCL Proteins) binding sites, which recruit vinculin (show VCL Proteins) to stabilize the complex.

  8. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.

  9. Talin1 and Rap1 are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss.

  10. Talin binding to the membrane-proximal NPxY is crucial for connecting alpha5beta1 to the actin cytoskeleton.

Zebrafish Talin 1 (TLN1) interaction partners

  1. suggest that Tln1-mediated Itgbeta1b plays a crucial role in maintaining cardiac sarcomeric Z-disks and endothelial/endocardial cell integrity in zebrafish

Talin 1 (TLN1) Protein Profile

Protein Summary

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.

Gene names and symbols associated with Talin 1 Proteins (TLN1)

  • talin 1 (TLN1)
  • talin 1 (tln1)
  • Talin 1 (Bm1_56490)
  • talin 1 (LOC100217512)
  • talin 1 (Tln1)
  • talin-1-like (LOC100856393)
  • ILWEQ protein
  • sb:cb854 protein
  • talin-1 protein
  • Tln protein
  • TLN1 protein
  • wu:fb05c02 protein

Protein level used designations for Talin 1 Proteins (TLN1)

talin 1 , Talin 1 , Talin-1 , talin-1-like , talin-1

474759 Canis lupus familiaris
496216 Xenopus laevis
696298 Macaca mulatta
733752 Xenopus (Silurana) tropicalis
6106180 Brugia malayi
100055501 Equus caballus
100217512 Taeniopygia guttata
100380665 Salmo salar
100408584 Callithrix jacchus
100471856 Ailuropoda melanoleuca
7094 Homo sapiens
395194 Gallus gallus
21894 Mus musculus
313494 Rattus norvegicus
783470 Bos taurus
494453 Danio rerio
100856393 Canis lupus familiaris
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