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catalyzes the transfer of the terminal phosphate of ATP to thymidine to form thymidine 5'-phosphate (dTMP) [RGD, Feb 2006].. Additionally we are shipping Thymidine Kinase 1, Soluble Antibodies (74) and Thymidine Kinase 1, Soluble Kits (32) and many more products for this protein.
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The down-regulation of Tk1 activity unmasks Tk2 deficiency in Tk2-/- mice and correlates with the onset of mtDNA depletion in the brain and the heart.
blood cells are less dependent on mitochondrial Tk2 compared with several other tissues; these cells can synthesize deoxyribonucleotides required for mtDNA replication by alternative pathways such as phosphorylation of thymidine by cytosolic Tk1
Mutations in the TK1 gene were studied in neonatal transgenic mice treated with AZT.
the small colony mutant phenotype in L5178Y lymphoma is not caused by deletion of both Trp53 (show TP53 Proteins) and thymidine kinase 1
The results have implications for the mechanism by which Fhit regulates TK1 mRNA, and more broadly, for its modulation of multiple functions as tumor suppressor/genome caretaker.
Results suggest that positive expression of CK19 (show KRT19 Proteins) mRNA and TK1 protein is closely correlated with poor prognosis in advanced gastrointestinal cancer.
though TK1 expression was an independent prognostic factor for relapse, but not for survival, TK1 is a more informative expression than Ki-67 (show MKI67 Proteins) for LI, relapse and overall survival rates. Thus, when TK1 is combined with MDACC grading, pTNM staging and lymph node metastasis, IHC determination of TK1 expression may improve the overall prediction of prognosis in patients with ovarian cancer.
Data show that the median thymidine kinase (TK1) levels found in sera from breast cancer patients with T1 to T4 stage disease were 0.31, 0.46, 0.47, and 0.55 ng/ml, and these levels significantly differed from healthy controls.
STK1 (show CDK7 Proteins) is a reliable biomarker for discovering people with malignant tumors in cancer screening.
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma (show MOK Proteins) and Radiofrequency Ablation of Metastases to Lung and Liver
TK1 expression is significantly different in invasive urothelial carcinoma and benign urothelium, which underlines its potential as a diagnostic marker
Protein expression of BIRC5 (show BIRC5 Proteins), TK1, and TOP2A (show TOP2A Proteins) in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.
High Thymidine Kinase expression is associated with adenocarcinoma in Non-small Cell Lung Cancer.
These results demonstrate that there are differences in the specific activities and the subunit compositions of STK1 (show CDK7 Proteins) in hematological malignancies compared with breast and prostate cancer.
catalyzes the transfer of the terminal phosphate of ATP to thymidine to form thymidine 5'-phosphate (dTMP)
, thymidine kinase, cytosolic
, thymidine kinase 1, soluble
, thymidine kinase 1
, Thymidine kinase, cytosolic
, thymidine kinase
, thymidine kinase 1 soluble isoform
, thymidine kinase-1