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anti-Thymidylate Synthetase (TYMS) Antibodies

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. Additionally we are shipping Thymidylate Synthetase Proteins (18) and Thymidylate Synthetase Kits (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TYMS 22171 P07607
TYMS 7298 P04818
TYMS 29261 P45352
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Top anti-Thymidylate Synthetase Antibodies at antibodies-online.com

Showing 10 out of 275 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TYMS Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Sheep Un-conjugated FM, IP, IHC, ELISA, WB 2 mL Log in to see 2 to 3 Days
$1,035.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to TYMS on HeLa cell (antibody concentration 20 µg/mL). TYMS monoclonal antibody (M01), clone 3A1 Western Blot analysis of TYMS expression in HeLa. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p) 1 mL Log in to see 6 to 8 Days
$797.50
Details
Human Rabbit Un-conjugated FM, IP, IHC, ELISA, WB Anti-TS is shown to detect thymidylate synthase present in a HeLa cell extract. Each lane is estimated to contain 4 ug of protein. Lanes 1, 2 and 3 represent 1:500, 1:1,000 and 1:2,000 fold dilutions of the antibody. Detection was made using HRP Goat-a-Rabbit IgG (611-1302) diluted 1:1,000 and color development using TMB (TMBM-100) substrate for approximately 4'. 100 μL Log in to see 2 to 3 Days
$387.45
Details
Human Sheep Un-conjugated EIA, IF, IHC (p), IP, WB 50 μL Log in to see 6 to 8 Days
$500.50
Details
Human Sheep Un-conjugated EIA, IHC (fro), IP, WB   2 mL Log in to see 6 to 8 Days
$1,435.50
Details
Human Mouse Un-conjugated IHC (fro), IF, IHC (p), WB 1 mL Log in to see 6 to 8 Days
$544.50
Details
Human Rabbit Un-conjugated EIA, IHC (fro), IF, IP, WB Anti-TS is shown to detect thymidylate synthase present in a HeLa cell extract. Each lane is estimated to contain 4 ug of protein. Lanes 1, 2 and 3 represent 1:500, 1:1,000 and 1:2,000 fold dilutions of the antibody. Detection was made using HRP Goat-a-Rabbit IgG (611-1302) diluted 1:1,000 and color development using TMB (TMBM-100) substrate for approximately 4'. 100 μL Log in to see 10 to 12 Days
$508.20
Details

TYMS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Thymidylate Synthetase Antibodies

  1. Human Monoclonal TYMS Primary Antibody for IF, WB - ABIN393644 : Kristensen, Pedersen, Melsen, Ellehauge, Mejer: Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients. in The Journal of international medical research 2010 (PubMed)
    Show all 5 references for ABIN393644

  2. Human Monoclonal TYMS Primary Antibody for EIA, IF - ABIN452662 : Shahrokni, Rajebi, Saif: Toxicity and efficacy of 5-fluorouracil and capecitabine in a patient with TYMS gene polymorphism: A challenge or a dilemma? in Clinical colorectal cancer 2009 (PubMed)
    Show all 3 references for ABIN452662

  3. Human Polyclonal TYMS Primary Antibody for FM, IP - ABIN107487 : Sohn, Croxford, Yates, Lucock, Kim: Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. in Journal of the National Cancer Institute 2004 (PubMed)
    Show all 2 references for ABIN107487

  4. Human Polyclonal TYMS Primary Antibody for EIA, IHC (fro) - ABIN2853636 : Haqqani, Cowling, Maroun, Birnboim: Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 (PubMed)

  5. Cow (Bovine) Polyclonal TYMS Primary Antibody for WB - ABIN2783412 : Ikeda, Sasazuki, Natsukawa, Shaura, Koizumi, Kasuga, Ohnami, Sakamoto, Yoshida, Iwasaki, Tsugane: Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. in The American journal of gastroenterology 2008 (PubMed)

  6. Human Polyclonal TYMS Primary Antibody for FM, IP - ABIN2801851 : Conradi, Bleckmann, Schirmer, Sprenger, Jo, Homayounfar, Wolff, Rothe, Middel, Becker, Ghadimi, Beissbarth, Liersch: Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment. in Annals of surgical oncology 2011 (PubMed)

More Antibodies against Thymidylate Synthetase Interaction Partners

Mouse (Murine) Thymidylate Synthetase (TYMS) interaction partners

  1. Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed

  2. SHMT1 (show SHMT1 Antibodies) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA

  3. Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (show ELF2 Antibodies) GABP and Sp1 (show SP1 Antibodies).

  4. downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 Antibodies)

  5. posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd

Human Thymidylate Synthetase (TYMS) interaction partners

  1. Thymidylate Synthase Polymorphisms are associated with the Risk of Lung Cancer.

  2. Study suggests a novel function of HSP90 (show HSP90 Antibodies)-Src (show SRC Antibodies) pathway in regulation of TYMS expression and acquisition of 5-FU resistance in colon cancer.

  3. The expression of thymidylate synthase and its correlation with survival in stage II/III gastric cancer patients

  4. TYMS overexpression was detected in 61 % of non-small cell lung cancer patients and low expression in 39 %.

  5. The study suggests that patients carrying rs183205964, a G>C substitution in the promoter enhancer region of TYMS, are at strongly increased risk of severe, potentially life-threatening, toxicity when treated with fluoropyrimidines.

  6. SAHA and 5-FU act synergistically to inhibit cell growth and tumorigenicity in Hepatocellular carcinoma via the induction of cell-cycle arrest and apoptosis through a mechanism involving the inhibition of thymidylate synthase

  7. Colorectal cancer patients with low expression of ERCC1 (show ERCC1 Antibodies) and thymidylate synthase have better response to therapy and show longer survival.

  8. our data suggest that SNPs rs2847153 in TYMS gene may be a potential biomarker for predicting clinical outcome and personalized treatment in NSCLC patients.

  9. Genetic association study of MTHFR (show MTHFR Antibodies) C677T polymorphism and TYMS tandem repeats in oral squamous cell carcinoma (OSCC) risk showed only TYMS tandem repeat may be associated with OSCC development.

  10. Dihydrofolate Reductase (show DHFR Antibodies) and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.

Thymidylate Synthetase (TYMS) Antigen Profile

Protein Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Gene names and symbols associated with TYMS

  • thymidylate synthetase (TYMS) antibody
  • thymidylate synthetase (thyA) antibody
  • thymidylate synthetase (td) antibody
  • thymidylate synthetase (thyE) antibody
  • thymidylate synthetase (LOC100037674) antibody
  • thymidylate synthetase (tyms) antibody
  • thymidylate synthetase (LOC100222097) antibody
  • thymidylate synthase (Tyms) antibody
  • thymidylate synthetase (Tyms) antibody
  • ECK2823 antibody
  • FN1 antibody
  • HST422 antibody
  • JW2795 antibody
  • TMS antibody
  • TS antibody

Protein level used designations for TYMS

fibronectin 1 , thymidylate synthase , thymidylate synthetase , thymidylate synthase-like , Tsase , TSase , TS

GENE ID SPECIES
740018 Pan troglodytes
949035 Escherichia coli str. K-12 substr. MG1655
4156567 Aeromonas phage 25
4405636 Enterobacteria phage RB32
7803492 Enterobacteria phage RB51
9415915 Ralstonia solanacearum CFBP2957
9431860 Xenorhabdus nematophila ATCC 19061
9487079 Staphylococcus aureus
9732454 Dickeya dadantii 3937
100037674 Ovis aries
100125228 Xenopus laevis
100222097 Taeniopygia guttata
100459110 Pongo abelii
697580 Macaca mulatta
7803982 Enterobacteria phage RB14
7992740 Methylobacterium extorquens AM1
8195292 Methylobacterium extorquens DM4
8833316 Xenorhabdus bovienii SS-2004
8913233 Erwinia amylovora CFBP1430
9404045 Herbaspirillum seropedicae SmR1
9408872 Ralstonia solanacearum PSI07
22171 Mus musculus
7298 Homo sapiens
29261 Rattus norvegicus
507631 Bos taurus
100627209 Sus scrofa
421060 Gallus gallus
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