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Tousled-Like Kinase 1 Proteins (TLK1)

The protein encoded by TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. Additionally we are shipping Tousled-Like Kinase 1 Antibodies (112) and Tousled-Like Kinase 1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TLK1 9874 Q9UKI8
TLK1 228012 Q8C0V0
Rat TLK1 TLK1 311118  
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Top Tousled-Like Kinase 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TLK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced Tousled-Like Kinase 1 Proteins

  1. Human TLK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005117 : Silljé, Nigg: Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. in Current biology : CB 2001 (PubMed)
    Show all 3 references for ABIN2005117

More Proteins for Tousled-Like Kinase 1 (TLK1) Interaction Partners

Caenorhabditis elegans (C. elegans) Tousled-Like Kinase 1 (TLK1) interaction partners

  1. TLK-1 contributes to chromosome condensation and segregation;TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.

  2. Tousled-like kinase (TLK-1) contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase AIR-2.

Human Tousled-Like Kinase 1 (TLK1) interaction partners

  1. TLK1B mediated phosphorylation of Rad9 (show RAD9A Proteins) regulates its nuclear/cytoplasmic localization and cell cycle checkpoint

  2. Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a (show ASF1A Proteins) and Asf1b (show ASF1B Proteins) function.

  3. Tousled-like kinase-dependent phosphorylation of Rad9 (show RAD9A Proteins) plays a role in cell cycle progression and G2/M checkpoint exit.

  4. Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.

  5. Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage.

  6. ASF1 (show SRSF1 Proteins) cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 (show SRSF1 Proteins) and hASF1a (show ASF1A Proteins) by TLK (show TLK2 Proteins) kinases.

  7. we show that Chk1 (show CHEK1 Proteins) is essential for the suppression of TLK (show TLK2 Proteins) activity after replication block, but that ATR (show ANTXR1 Proteins), Chk2 (show CHEK2 Proteins) and BRCA1 are dispensable for TLK (show TLK2 Proteins) suppression.

  8. Both eIF4E (show EIF4E Proteins) and TLK1B are elevated in breast cancer specimens but not in benign breast specimens from noncancer patients. Degree of TLK1B elevation is correlated with degree of IF4E (show EIF4E2 Proteins) overexpression.

  9. In addition, it could be demonstrated that increasing the Tlk1 activity in HT1080 (show CDC123 Proteins) cells by forced Tlk1 overexpression leads to an increased phosphorylation of endogenous p68 (show ANXA6 Proteins).

  10. Studies provide evidence for TLK1B-mediated phosphorylation of Asf1 (show SRSF1 Proteins) triggering DNA repair.

Mouse (Murine) Tousled-Like Kinase 1 (TLK1) interaction partners

Tousled-Like Kinase 1 (TLK1) Protein Profile

Protein Summary

The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tousled-Like Kinase 1 Proteins (TLK1)

  • tousled-like kinase 1 (TLK1)
  • tousled-like kinase 1b (tlk1b)
  • tousled-like kinase 1 (LOC542181)
  • tousled-like kinase 1 (tlk1)
  • Protein TLK-1 (tlk-1)
  • tousled-like kinase 1 (Tlk1)
  • tousled-like kinase 1a (tlk1a)
  • 4930545J15Rik protein
  • DKFZp459L163 protein
  • fb76h12 protein
  • fe11e12 protein
  • PKU-beta protein
  • si:dkey-88m1.1 protein
  • si:dkey-251e16.4 protein
  • tlk1 protein
  • wu:fb76h12 protein
  • wu:fe11e12 protein

Protein level used designations for Tousled-Like Kinase 1 Proteins (TLK1)

tousled-like kinase 1 , pKU-beta protein kinase , serine/threonine-protein kinase tousled-like 1-B , tousled-like kinase 1-B , SNARE protein kinase SNAK , serine threonine protein kinase , serine/threonine-protein kinase tousled-like 1

GENE ID SPECIES
281533 Bos taurus
326734 Danio rerio
429024 Gallus gallus
459729 Pan troglodytes
478795 Canis lupus familiaris
537517 Bos taurus
542181 Zea mays
100024843 Monodelphis domestica
100052963 Equus caballus
100144941 Xenopus (Silurana) tropicalis
100157412 Sus scrofa
100174001 Pongo abelii
100345497 Oryctolagus cuniculus
100554902 Anolis carolinensis
100591136 Nomascus leucogenys
176369 Caenorhabditis elegans
9874 Homo sapiens
228012 Mus musculus
311118 Rattus norvegicus
557765 Danio rerio
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