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The protein encoded by TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. Additionally we are shipping Tousled-Like Kinase 1 Antibodies (112) and Tousled-Like Kinase 1 Kits (1) and many more products for this protein.
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Human TLK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005117
Silljé, Nigg: Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. in Current biology : CB 2001
Show all 3 references for ABIN2005117
TLK-1 contributes to chromosome condensation and segregation;TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.
Tousled-like kinase (TLK-1) contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase AIR-2.
Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a (show ASF1A Proteins) and Asf1b (show ASF1B Proteins) function.
Tousled-like kinase-dependent phosphorylation of Rad9 (show RAD9A Proteins) plays a role in cell cycle progression and G2/M checkpoint exit.
Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.
Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage.
ASF1 (show SRSF1 Proteins) cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 (show SRSF1 Proteins) and hASF1a (show ASF1A Proteins) by TLK (show TLK2 Proteins) kinases.
we show that Chk1 (show CHEK1 Proteins) is essential for the suppression of TLK (show TLK2 Proteins) activity after replication block, but that ATR (show ANTXR1 Proteins), Chk2 (show CHEK2 Proteins) and BRCA1 are dispensable for TLK (show TLK2 Proteins) suppression.
Both eIF4E (show EIF4E Proteins) and TLK1B are elevated in breast cancer specimens but not in benign breast specimens from noncancer patients. Degree of TLK1B elevation is correlated with degree of IF4E (show EIF4E2 Proteins) overexpression.
In addition, it could be demonstrated that increasing the Tlk1 activity in HT1080 (show CDC123 Proteins) cells by forced Tlk1 overexpression leads to an increased phosphorylation of endogenous p68 (show ANXA6 Proteins).
Studies provide evidence for TLK1B-mediated phosphorylation of Asf1 (show SRSF1 Proteins) triggering DNA repair.
Our data suggest that human PKU-beta/TLK1 plays an important role in chromosome integrity via the regulation of myosin II dynamics by phosphorylating MRLC during mitosis.
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
tousled-like kinase 1
, pKU-beta protein kinase
, serine/threonine-protein kinase tousled-like 1-B
, tousled-like kinase 1-B
, SNARE protein kinase SNAK
, serine threonine protein kinase
, serine/threonine-protein kinase tousled-like 1