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The protein encoded by TRPM7 is both an ion channel and a serine/threonine protein kinase. Additionally we are shipping TRPM7 Proteins (7) and TRPM7 Kits (5) and many more products for this protein.
Showing 10 out of 175 products:
Mammalian Monoclonal TRPM7 Primary Antibody for ISt, IHC - ABIN1305027
Du, Xie, Zhang, Tsujikawa, Fusco, Silverman, Liang, Yue: TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. in Circulation research 2010
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Human Polyclonal TRPM7 Primary Antibody for IHC (p), WB - ABIN392614
Gavenis, Schumacher, Schneider, Eisfeld, Mollenhauer, Schmidt-Rohlfing: Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes. in Molecular and cellular biochemistry 2009
Show all 2 Pubmed References
Polyclonal TRPM7 Primary Antibody for IP, WB - ABIN540389
Runnels, Yue, Clapham: TRP-PLIK, a bifunctional protein with kinase and ion channel activities. in Science (New York, N.Y.) 2001
Show all 2 Pubmed References
Mouse (Murine) Polyclonal TRPM7 Primary Antibody for IHC (p), IHC - ABIN257037
Nadler, Hermosura, Inabe, Perraud, Zhu, Stokes, Kurosaki, Kinet, Penner, Scharenberg, Fleig: LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. in Nature 2001
tct may represent a novel as well as selective regulator of melanoblast development within the neural crest lineage.
Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.
TRPM7 plays a role within sensory neurons in modulating neutrotransmitter release at central synapses, similar to the role proprosed for mammalian TRPM7 at peripheral synapses.
Trpm7 regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Antibodies)+)-sensitive Socs3a (show SOCS3 Antibodies) pathway.
This study showed that stanniocalcin 1 (stc1 (show STC1 Antibodies))modulates cation levels in trpm7 mutants and in the wild type; levels of cations are restored to normal in trpm7 mutants when stc1 (show STC1 Antibodies) activity is blocked.
Mutation in trpm7 leads to defective skeletogenesis and kidney stone formation.
Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.
The results suggest that TRPM7 is required for proliferation, migration and invasion of ovarian cancer cells through regulating multiple signaling transduction pathways and the formation of focal adhesions.
The melastatin (show TRPM1 Antibodies)-like transient receptor potential cation channel (show TRPV1 Antibodies), subfamily M, member 7 (TRPM7), which is responsible for Mg(2 (show MUC7 Antibodies)+) entry, was studies and [Mg(2 (show MUC7 Antibodies)+)]i measured in cells stably expressing wildtype CFTR (show CFTR Antibodies), and two mutant proteins (DeltaF508-CFTR (show CFTR Antibodies) and G551D-CFTR (show CFTR Antibodies)). This study shows for the first time that [Mg(2 (show MUC7 Antibodies)+)]i is decreased in cells expressing DeltaF508-CFTR (show CFTR Antibodies) and G551D-CFTR (show CFTR Antibodies) mutated proteins.
Variability of the TRPM7 current density in human cardiomyocytes is related to the clinical history, being higher in atrial fibrillation and in ischemic cardiomyopathy.
our results show that TRPM7 is involved in PDAC cell invasion through regulation of Hsp90alpha (show HSP90AA2 Antibodies)/uPA (show PRAP1 Antibodies)/MMP-2 (show MMP2 Antibodies) proteolytic axis, confirming that this channel could be a promising biomarker and possibly a target for PDAC metastasis therapy.
Data show that activated TRPM7 activity contributes to the devastating migratory and invasive characteristics of glioblastoma (GBM) .
Bradykinin promoted migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2 (show MMP2 Antibodies).
chronic aldosterone treatment increases the plasma membrane expression of TRPM7, which is associated with an increase of TRPM7 current. This process occurs via an MR-dependent, genomic signaling cascade involving SGK1 (show SGK1 Antibodies) and a functioning TRPM7 alpha-kinase domain.
expression of TRPM7 has an impact on the prognosis of patients with esophageal squamous cell carcinoma
TRPM7 is part of a large cytoskeletal complex that may affect the malignant potential of tumor cells by regulating actomyosin dynamics and cell-matrix interactions.
TRPM7 and STAT3 (show STAT3 Antibodies) activation might be critical for the growth of NPC (show NPC1 Antibodies) cells.
TRPM7 kinase activity regulates mast cell degranulation by changing its sensitivity to intracellular calcium.
Inhibition of TRPM7 reduces calcium influx and accelerates the polarization of hippocampal neurons.
our results suggest the differential roles of TRPM7 in endochondral and intramembranous ossification.
TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice.
TRPM7 kinase is a novel player in Angiotensin II induced hypertension and vascular and target organ damage.
Immature intercellular junctions in Trpm7 knock-out mice might lead to a disruption of barrier function resulting in inflammation and hypersensitive bladder afferent nerves that may affect voiding behavior in vivo
By inhibiting TRPM7 and ANO1 (show ANO1 Antibodies) via opioid receptor signaling pathways.
Abolishing TRPM7 kinase activity does not impair its channel activity and kinase activity is not essential for regulation of mammalian Mg(2 (show MCOLN1 Antibodies)+) homeostasis.
results suggest that TRPM7 kinase is a sensor of magnesium status and provides coordination of cellular and systemic responses to magnesium deprivation.
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.
transient receptor potential cation channel subfamily M member 7
, transient receptor potential melastatin 7
, transient receptor potential cation channel, subfamily M, member 7
, LTRPC ion channel family member 7
, channel-kinase 1
, long transient receptor potential channel 7
, transient receptor potential-phospholipase C-interacting kinase
, transient receptor potential M7
, transient receptor potential-related protein, ChaK