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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Additionally we are shipping GABRA2 Kits (14) and and many more products for this protein.
Showing 10 out of 88 products:
Cow (Bovine) Polyclonal GABRA2 Primary Antibody for WB - ABIN2792259
Hadingham, Wingrove, Le Bourdelles, Palmer, Ragan, Whiting: Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric ac in Molecular pharmacology 1993
Show all 3 references for ABIN2792259
Human Polyclonal GABRA2 Primary Antibody for FACS, IHC (p) - ABIN653245
Dixon, Morris, Breen, Desrivieres, Jugurnauth, Steiner, Vallada, Guindalini, Laranjeira, Messas, Rosahl, Atack, Peden, Belelli, Lambert, King, Schumann, Stephens: Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors. in Proceedings of the National Academy of Sciences of the United States of America 2010
the developmental shift in GABA(A) receptor alpha subunit (show POLG Antibodies) expression continues through adolescence in primate dorsolateral prefrontal cortex
parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p = .05). The association between life events and subsequent adolescent externalizing was stronger for adolescents with 0 copies of the G minor allele compared to those with 1 or 2 copies of the minor allele
A GABRA2 x Parental Monitoring effect on externalizing behavior trajectory was observed, such that A-carriers were largely unaffected by parental monitoring, whereas trajectory for those with the GG genotype was affected by parental monitoring.
GABRA2 SNPs directly predicted adolescent alcohol problems.
Alcohol dependence-associated variation in GABRA2 is associated with differential expression of the entire cluster of GABAA (show GABRg1 Antibodies) subunit genes on chromosome 4p12 in neural stem cells.
Recent drinking history (p = 0.01), and recent drinking history x genotype interaction (p = 0.01) were significantly associated with acute adaptation of the subjective responses to alcohol for the GABRA2 SNP rs279858.
The results of this study support a growing body of evidence linking GABAA (show GABRg1 Antibodies) receptors with the development of alcohol tolerance, dependence and withdrawal symptoms
GABRA2 is significantly associated with rule breaking in mid- to late adolescence, but not substance abuse symptomatology across adolescence.
GABRA2 genetic variants play a role in antipsychotic-associated weight gain.
The results suggest that SNP variation in the GABRA2 gene leads to higer risk of increased drunkenness in the period adolescence to you adulthood
Results suggest that the genetic effect of GABRA2 on externalizing behavior, more specifically on rule breaking is, at least in part, due to its effect on susceptibility to environmental exposure (i.e., peer delinquency)
Results indicate that 174 proteins were associated with gamma-aminobutyric acid receptor subunit alpha 2 (pHalpha2).
Wild-type and mutant mice have similar baseline nociceptive sensitivities and develop similar hyperalgesia specifically targeting alpha2-GABAA (show GABRg1 Antibodies) receptors which exert their antihyperalgesic effect through enhanced spinal nociceptive control.
GABRA2 subunit expression in hippocampus modulates neurogenesis through nuclear factor of activated T cell (show NFATC3 Antibodies) (NFATc)4 (show NFATC4 Antibodies) activity.
Disrupting the clustering of GABAA (show GABRg1 Antibodies) receptor alpha2 subunits in the frontal cortex leads to reduced gamma-power and cognitive deficits.
Recovery of function following alcoholic intoxication is regulated by Gabra2 and Gabra3 (show GABRA3 Antibodies) receptor subunits.
These findings suggest that alpha2-containing GABA(A) receptors expressed in the CA3 (show CA3 Antibodies) region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations
The results of this study emphasize the critical role of GABAergic synaptic signaling for structural maturation of adult-born GCs (show UGCG Antibodies) and formation of glutamatergic synapses.
Data suggest that the availability of distinct GABA(A) R subtypes (Gabra2, -4, and Gabrd) provides a molecular mechanism endowing spatiotemporal specificity to GABAergic control of neuronal maturation in adult brain.
presynaptic GABAA (show GABRg1 Antibodies) receptors residing on the axons or terminals of primary nociceptors play a significant role in spinal pain control.
Arc and Fos, increased about 250% in the alpha2 mutants, Behavioral effects (loss of righting reflex, rotarod) of flurazepam and pentobarbital were not different between alpha2 mutants and wild-type, but they were enhanced for alpha1 knock-in mice.
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
GABA(A) receptor subunit alpha-2
, gamma-aminobutyric acid receptor subunit alpha-2
, GABA-A receptor alpha-1 subunit
, gamma-aminobutyric acid (GABA) A receptor, alpha 2
, gamma-aminobutyric acid A receptor alpha 2
, gamma-aminobutyric acid A receptor, alpha 2 precursor-like
, GABA(A) receptor, alpha 2
, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2
, gamma-aminobutyric acid receptor A2 subunit
, gamma-aminobutyric acid A receptor, alpha 2